Novel selective melanocortin 4 receptor antagonist induces food intake after peripheral administration

scientific article

Novel selective melanocortin 4 receptor antagonist induces food intake after peripheral administration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-291X(02)03065-6
P698PubMed publication ID12565874

P50authorHelgi B. SchiöthQ30112644
P2093author name stringJarl E S Wikberg
Ilze Mutule
Ruta Muceniece
Ants Kask
Ilona Mandrika
Felikss Mutulis
Ilga Mutule
P2860cites workDiscovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo.Q52181998
Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamicsQ69360120
Characterisation of the melanocortin 4 receptor by radioligand bindingQ71712692
Characterisation of melanocortin receptor subtypes by radioligand binding analysisQ72296957
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body massQ74268345
Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding ratsQ74424364
Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in ratsQ77329257
Long-term administration of MC4 receptor antagonist HS014 causes hyperphagia and obesity in ratsQ77340752
Melanocortins and reproductionQ77758174
A role for the melanocortin 4 receptor in sexual functionQ24535020
Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptidesQ28257807
Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover studyQ28277664
Role of melanocortinergic neurons in feeding and the agouti obesity syndromeQ28300979
Targeted disruption of the melanocortin-4 receptor results in obesity in miceQ28302831
Discovery of novel melanocortin4receptor selective MSH analoguesQ29026417
Gonadotropin releasing hormone agonist treatment for central precocious pubertyQ33791394
Association between an agouti-related protein gene polymorphism and anorexia nervosaQ33944540
The physiological role of melanocortin receptorsQ34254198
Anorexia, sarcopenia, and agingQ34305739
Selectivity of cyclic [D-Nal7] and [D-Phe7] substituted MSH analogues for the melanocortin receptor subtypesQ36889306
Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recepQ41301816
Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonistQ42958574
Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in ratsQ44028436
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)399-405
P577publication date2003-02-01
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleNovel selective melanocortin 4 receptor antagonist induces food intake after peripheral administration
P478volume301

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cites work (P2860)
Q47836770Blockage of melanocortin-4 receptors by intranasal HS014 attenuates single prolonged stress-triggered changes in several brain regions
Q35676897Design of cyclic and other templates for potent and selective peptide alpha-MSH analogues
Q35610786Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.
Q92411354Potential metabolic and behavioural roles of the putative endocannabinoid receptors GPR18, GPR55 and GPR119 in feeding
Q36729120Recent progress toward nonpeptide ligands for the melanocortin-4 receptor