Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade

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Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...743594Z
P356DOI10.1371/JOURNAL.PONE.0043594
P932PMC publication ID3424201
P698PubMed publication ID22927998
P5875ResearchGate publication ID230749439

P50authorEe Hong TanQ59704539
Shing Chuan HooiQ59704544
P2093author name stringAlan Prem Kumar
Manuel Salto-Tellez
Shiuan Koh
Celestial T Yap
Benedict Yan
Hwee Kee Tay
Manikandan Jayapal
Yaw Chyn Lim
Yaw Chong Goh
Sutherland K Maciver
Lalchhandami Tochhawng
Jingli Zhuo
P2860cites workLIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cellsQ24336347
Epithelial-mesenchymal transitions in tumour progressionQ27860487
Gene Expression Omnibus: NCBI gene expression and hybridization array data repositoryQ27860523
Cancer statistics, 2010Q27860525
A genetic model for colorectal tumorigenesisQ27860582
Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasionQ28142815
Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolinQ28189293
Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulatorQ28203788
Binding of gelsolin domain 2 to actin. An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilinQ28208574
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancerQ28237051
Invadopodia: specialized cell structures for cancer invasionQ28251084
Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolinQ28300043
Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodiaQ28300785
Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancerQ28506447
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cellsQ29619848
Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiencyQ30485711
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.Q33350682
Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei.Q33883078
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environmentQ33943198
Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasionQ34354046
Complex roles of tissue inhibitors of metalloproteinases in cancerQ34596110
Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosisQ35640692
Evolution of the gelsolin family of actin-binding proteins as novel transcriptional coactivators.Q36072167
Nuclear actin-binding proteins as modulators of gene transcriptionQ36247425
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strengthQ36316394
Hypoxia-driven selection of the metastatic phenotypeQ36801461
A new role for cortactin in invadopodia: regulation of protease secretionQ37110536
Invadopodia: at the cutting edge of tumour invasion.Q37158821
Nucleating actin for invasionQ37843451
TNF-alpha increases human melanoma cell invasion and migration in vitro: the role of proteolytic enzymesQ38305465
Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinomaQ38356065
Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancersQ38460154
Palladin, an actin-associated protein, is required for adherens junction formation and intercellular adhesion in HCT116 colorectal cancer cellsQ39660578
TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cellsQ39661707
Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signalingQ39693219
Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitroQ40134472
siRNA gelsolin knockdown induces epithelial-mesenchymal transition with a cadherin switch in human mammary epithelial cellsQ40363300
Exploitation of astrocytes by glioma cells to facilitate invasiveness: a mechanism involving matrix metalloproteinase-2 and the urokinase-type plasminogen activator-plasmin cascade.Q40645479
Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motilityQ40738595
Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.Q41469995
The urokinase-type plasminogen activator system in cancer metastasis: A reviewQ41522331
Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancerQ41674938
Clinical significance of levels of molecular biological markers in zones of invasive front-line of colorectal cancerQ42455441
Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridizationQ42478423
Gelsolin is a downstream effector of rac for fibroblast motilityQ42639554
Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humansQ42756488
Plasminogen activator system, vascular endothelial growth factor, and colorectal cancer progressionQ42937214
Binding site of amiloride to urokinase plasminogen activator depends on speciesQ43741546
Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expressionQ44475954
In colon carcinogenesis, the cytoskeletal protein gelsolin is down-regulated during the transition from adenoma to carcinoma.Q53318985
High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-22.Q53512996
Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis.Q53579640
Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanismQ59571861
Monoclonal antibodies to cytoskeletal proteins: an immunohistochemical investigation of human colon cancerQ70506601
Dependence of fibroblast migration on actin severing activity of gelsolinQ71246159
Downregulation of gelsolin correlates with the progression to breast carcinomaQ73602848
Frequent loss of gelsolin expression in non-small cell lung cancers of heavy smokersQ74093433
Urokinase-type plasminogen activator in colorectal cancer: relationship with clinicopathological features and patient outcomeQ77553509
Urokinase-mediated extracellular matrix degradation by human prostatic carcinoma cells and its inhibition by retinoic acidQ77555953
Cortactin is associated with perineural invasion in the deep invasive front area of laryngeal carcinomasQ83653069
Tissue expression of gelsolin in oral carcinogenesis progression and its clinicopathological implicationsQ83925322
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectcolonic neoplasmQ3542029
plasminogenQ107129060
P304page(s)e43594
P577publication date2012-08-21
P1433published inPLOS OneQ564954
P1476titleGelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade
P478volume7

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cites work (P2860)
Q56938762Capping Actin Protein Overexpression in Human Colorectal Carcinoma and Its Contributed Tumor Migration
Q88657525Comparative two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) of human milk to identify dysregulated proteins in breast cancer
Q47136419Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2 + dyshomeostasis in hepatocarcinoma PLC cells.
Q92813709Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective
Q39784847DHA-mediated regulation of lung cancer cell migration is not directly associated with Gelsolin or Vimentin expression
Q91004170Functional characterization of alternatively spliced GSN in head and neck squamous cell carcinoma
Q47364413Gelsolin regulates proliferation, apoptosis and invasion in NK/T-cell lymphoma cells.
Q37619672Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion
Q37295357Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma
Q35667354Gene Expression Profiling in Peripheral Blood Cells and Synovial Membranes of Patients with Psoriatic Arthritis
Q36085382Imaging of human pancreatic cancer xenografts by single-photon emission computed tomography with (99m)Tc-Hynic-PEG-AE105.
Q36159870MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines.
Q35075914Molecular characterization of severin from Clonorchis sinensis excretory/secretory products and its potential anti-apoptotic role in hepatocarcinoma PLC cells
Q58702505Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target
Q37375238Podocalyxin-like protein, linked to poor prognosis of pancreatic cancers, promotes cell invasion by binding to gelsolin

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