Unraveling peroxynitrite formation in biological systems.

scientific article

Unraveling peroxynitrite formation in biological systems. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0891-5849(00)00373-7
P698PubMed publication ID11182518

P50authorAlfonso CayotaQ59193530
P2093author name stringR Radi
M Naviliat
G Peluffo
M N Alvarez
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Peroxynitrite rapidly permeates phospholipid membranesQ28611785
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Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysisQ32173941
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Analytical methods for 3-nitrotyrosine as a marker of exposure to reactive nitrogen species: a reviewQ33547509
Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage.Q42474778
"NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage formsQ42554386
The formation of nitric oxide donors from peroxynitriteQ42708535
Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitriteQ42749725
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factorQ44087051
Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.Q45274479
Reactions of oxymyoglobin with NO, NO2, and NO2- under argon and in air.Q45945129
Quantitation of protein-bound 3-nitrotyrosine by high-performance liquid chromatography with electrochemical detection.Q45980704
Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasomeQ46198499
Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicityQ46316617
Tyrosine modification by reactive nitrogen species: a closer lookQ46738125
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophilsQ46943421
Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen speciesQ47774945
Characterization of the cytoprotective action of peroxynitrite decomposition catalystsQ47982104
Isotope dilution mass spectrometric quantification of 3-nitrotyrosine in proteins and tissues is facilitated by reduction to 3-aminotyrosineQ48028588
Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosineQ48034838
Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.Q48380256
Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation.Q48539215
Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both.Q50126739
Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure.Q50526979
Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.Q54071317
Glyceraldehyde-3-phosphate dehydrogenase inactivation by peroxynitrite.Q54112902
S-Nitroglutathione, a product of the reaction between peroxynitrite and glutathione that generates nitric oxide.Q54116069
Effect of xanthine oxidase inhibition on endothelium-dependent and nitrergic relaxations.Q54304187
Kinetic study of the reaction of ebselen with peroxynitrite.Q54332782
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1Q55042584
Xanthine Oxidase-mediated Decomposition ofS-NitrosothiolsQ56114948
[38] Detection of reactive nitrogen species using 2,7-dichlorodihydrfluorescein and dihydrorhodamine 123Q57204869
Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradationQ57204875
ALS, SOD and peroxynitriteQ59070047
Direct EPR Detection of the Carbonate Radical Anion Produced from Peroxynitrite and Carbon DioxideQ63286159
Peroxynitrite formation from macrophage-derived nitric oxideQ67505344
Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitriteQ67568058
Relationships between nitric oxide, nitroxyl ion, nitrosonium cation and peroxynitriteQ33631316
Kinetics of cytochrome c2+ oxidation by peroxynitrite: implications for superoxide measurements in nitric oxide-producing biological systemsQ34313420
Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shockQ34423158
Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA.Q34482199
Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidationQ34506243
Simulation of the diffusion and reaction of endogenously produced nitric oxideQ35684444
Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injuryQ35824606
Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathologyQ35933719
Diffusion of peroxynitrite across erythrocyte membranesQ36005247
Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosisQ36049347
Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detectionQ36083498
Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophagesQ36244224
An activity in rat tissues that modifies nitrotyrosine-containing proteinsQ36314143
Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovaniQ36367801
Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidationQ36406441
Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.Q36501983
Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Q36503887
Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxQ36662645
Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosineQ36668015
2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formationQ36891067
Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allograftsQ37272222
Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.Q37355847
Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbitsQ37417521
Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicalsQ37694736
Biosynthesis and metabolism of endothelium-derived nitric oxideQ37925395
Luminol and lucigenin as detectors for O2.-.Q40774003
Overexpression of CuZn superoxide dismutase protects RAW 264.7 macrophages against nitric oxide cytotoxicityQ40972249
Nitric oxide and peroxynitrite-dependent aconitase inactivation and iron-regulatory protein-1 activation in mammalian fibroblastsQ40995929
Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity.Q41051027
Nitrotyrosine as biomarker for reactive nitrogen speciesQ41100356
Detection and quantitation of nitrotyrosine residues in proteins: in vivo marker of peroxynitriteQ41100364
Antibodies that recognize nitrotyrosineQ41100374
Detection of secondary radicals from peroxynitrite-medicated oxidations by electron spin resonanceQ41100458
Endogenously produced peroxynitrite induces the oxidation of mitochondrial and nuclear proteins in immunostimulated macrophagesQ41105383
Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage.Q41116781
Reactions of nitric oxide with metalloproteinsQ41129369
The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury.Q41151395
Antisense manganese superoxide dismutase mRNA inhibits the antiviral action of interferon-gamma and interferon-alphaQ41253178
The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice.Q41728640
Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucoseQ41827439
Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifactsQ42248095
Peroxynitrite-induced luminol chemiluminescenceQ42267094
Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patientsQ42283943
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistryQ42285845
Cytochrome c-catalyzed oxidation of organic molecules by hydrogen peroxideQ68255394
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxideQ68255434
Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxideQ70870892
Nitric oxide synthase inhibitors decrease human polymorphonuclear leukocyte luminol-dependent chemiluminescenceQ70954050
Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathwayQ71038888
Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studiesQ71069881
Nitric oxide diffusion in membranes determined by fluorescence quenchingQ71097843
Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transportQ71112960
Mechanism of carbon dioxide-catalyzed oxidation of tyrosine by peroxynitriteQ71165693
Nitric oxide synthase inhibitors: amino acidsQ71472459
Carbon dioxide enhancement of peroxynitrite-mediated protein tyrosine nitrationQ71530791
Peroxynitrite reaction with carbon dioxide/bicarbonate: kinetics and influence on peroxynitrite-mediated oxidationsQ71530794
Modulatory role of nitric oxide on superoxide-dependent luminol chemiluminescenceQ71530842
Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurinationQ71584102
Peroxynitrite-dependent tryptophan nitrationQ71610119
The reaction of 2-(methylseleno)benzanilide with peroxynitriteQ71746680
Base modification and strand breakage in isolated calf thymus DNA and in DNA from human skin epidermal keratinocytes exposed to peroxynitrite or 3-morpholinosydnonimineQ71746710
Nitration and hydroxylation of phenolic compounds by peroxynitriteQ71790282
The reaction of NO. with O2.- and HO2.: a pulse radiolysis studyQ71818204
Sensitive determination of nitrotyrosine in human plasma by isocratic high-performance liquid chromatographyQ71855333
Effects of carbon dioxide/bicarbonate on induction of DNA single-strand breaks and formation of 8-nitroguanine, 8-oxoguanine and base-propenal mediated by peroxynitriteQ71937535
Desferrioxamine inhibition of the hydroxyl radical-like reactivity of peroxynitrite: Role of the hydroxamic groupsQ71958549
Peroxynitrite-mediated oxidation of dihydrorhodamine 123Q71999696
Peroxynitrite-mediated oxidation of albumin to the protein-thiyl free radicalQ72067272
On the pH-dependent yield of hydroxyl radical products from peroxynitriteQ72134929
Peroxynitrite-mediated oxidative protein modificationsQ72257512
Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediatesQ72370852
Agonist-induced peroxynitrite production from endothelial cellsQ72411586
Inhibition of mitochondrial electron transport by peroxynitriteQ72780942
Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evidence for hydroxyl radical production from peroxynitriteQ72787193
Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cellsQ72970166
Phenoxyl free radical formation during the oxidation of the fluorescent dye 2',7'-dichlorofluorescein by horseradish peroxidase. Possible consequences for oxidative stress measurementsQ73019257
A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in ratsQ73066471
Evidence for free radical formation during the oxidation of 2'-7'-dichlorofluorescin to the fluorescent dye 2'-7'-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative stress measurementsQ73069355
Factors determining the selectivity of protein tyrosine nitrationQ73141785
Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3-carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductantsQ73156337
Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivoQ73175886
The nitric oxide/superoxide assay. Insights into the biological chemistry of the NO/O-2. interactionQ73201806
Contribution of nitric oxide synthase to human neutrophil chemiluminescenceQ73282814
Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutaseQ73316561
Peroxynitrite generated from constitutive nitric oxide synthase mediates the early biochemical injury in short-term cultured hepatocytesQ73387660
Tyrosine nitration by simultaneous generation of (.)NO and O-(2) under physiological conditions. How the radicals do the jobQ73396445
Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formationQ73456344
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite. Implications for tyrosine modification by nitric oxide/superoxide in vivoQ73487376
Liposome-delivered superoxide dismutase prevents nitric oxide-dependent motor neuron death induced by trophic factor withdrawalQ73503948
Peroxynitrite-mediated nitration of peptides: characterization of the products by electrospray and combined gas chromatography-mass spectrometryQ73606616
Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detectionQ73702161
Ca2+-independent permeabilization of the inner mitochondrial membrane by peroxynitrite is mediated by membrane protein thiol cross-linking and lipid peroxidationQ73728037
Oxidation of 2',7'-dichlorofluorescin by peroxynitriteQ73831038
Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosisQ73907503
Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetised ratQ73962333
Ternary copper complexes and manganese (III) tetrakis(4-benzoic acid) porphyrin catalyze peroxynitrite-dependent nitration of aromaticsQ74071889
Formation of spin trap adducts during the decomposition of peroxynitriteQ74079147
Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonanceQ74088511
Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclaseQ74454430
Free radical formation in the peroxynitrous acid (ONOOH)/peroxynitrite (ONOO-) systemQ74457138
Reaction of peroxynitrite with HEPES or MOPS results in the formation of nitric oxide donorsQ74545825
3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivoQ74632307
Detection of 3-nitrotyrosine in human platelets exposed to peroxynitrite by a new gas chromatography/mass spectrometry assayQ74663910
Peroxynitrite reactions and diffusion in biologyQ74793022
Detection of superoxide radicals and peroxynitrite by 1-hydroxy-4-phosphonooxy-2,2,6,6-tetramethylpiperidine: quantification of extracellular superoxide radicals formationQ74801520
Peroxynitrite production by human neutrophils, monocytes and lymphocytes challenged with lipopolysaccharideQ74823754
Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen speciesQ77077439
Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donorQ77229046
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimicQ77229067
Design of isoform-selective inhibitors of nitric oxide synthaseQ77297321
Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxideQ77313286
Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activationQ77394071
New aspects in the reaction mechanism of phenol with peroxynitrite: the role of phenoxy radicalsQ77675220
Kinetics of peroxynitrite reaction with amino acids and human serum albuminQ77747890
Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductantsQ77752845
Evidence for iNOS-dependent peroxynitrite production in diabetic plateletsQ77762863
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formationQ77807902
Peroxynitrite scavenging by different antioxidants. Part I: convenient assayQ77834561
Measurement and significance of free and protein-bound 3-nitrotyrosine, 3-chlorotyrosine, and free 3-nitro-4-hydroxyphenylacetic acid in biologic samples: a high-performance liquid chromatography method using electrochemical detectionQ77908008
Peroxynitrite reactions with carbon dioxide-bicarbonateQ77908098
Immunohistochemical methods to detect nitrotyrosineQ77908108
Diffusion of peroxynitrite in the presence of carbon dioxideQ78025585
Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disordersQ78177642
3-Nitrotyrosine in the proteins of human plasma determined by an ELISA methodQ95433787
P433issue5
P304page(s)463-488
P577publication date2001-03-01
P1433published inFree Radical Biology and MedicineQ5500023
P1476titleUnraveling peroxynitrite formation in biological systems
P478volume30

Reverse relations

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Q92219934Maternal Smoking Highly Affects the Function, Membrane Integrity, and Rheological Properties in Fetal Red Blood Cells
Q46036344Measurement of Antioxidant Activity of Wine Catechins, Procyanidins, Anthocyanins and Pyranoanthocyanins.
Q35047134Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?
Q37936512Mechanisms and consequences of oxidative damage to extracellular matrix.
Q28397657Mechanisms of Peroxynitrite Interactions with Heme Proteins
Q33848167Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology
Q37900675Melatonin as a natural ally against oxidative stress: a physicochemical examination.
Q44604274Melatonin protects against pro‐oxidant enzymes and reduces lipid peroxidation in distinct membranes induced by the hydroxyl and ascorbyl radicals and by peroxynitrite
Q50709905Melatonin reduces ventricular arrhythmias and preserves capillary perfusion during ischemia-reperfusion events in cardiomyopathic hamsters.
Q36203539Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids
Q34854255Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.
Q92377698Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives
Q55092510Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity.
Q44808732Mobilization of intracellular calcium by peroxynitrite in arteriolar smooth muscle cells from rats
Q30924768Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers
Q44390234Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome
Q39340905Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme
Q35838851Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions
Q42907578NO synthase isoforms specifically modify peroxynitrite reactivity.
Q39231622Nanotechnology for Electroanalytical Biosensors of Reactive Oxygen and Nitrogen Species
Q37924114Natural salicylates: foods, functions and disease prevention
Q38424828New concepts to fight oxidative stress: nanosized three-dimensional supramolecular antioxidant assemblies
Q31113795Nitration and chlorination of folic acid by peroxynitrite and hypochlorous acid, and the selective binding of 10-nitro-folate to folate receptor beta.
Q44020609Nitration of cytoskeletal proteins in the chicken embryo chorioallantoic membrane.
Q46905160Nitration of profilin effects its interaction with poly (L-proline) and actin
Q38257664Nitration of the birch pollen allergen Bet v 1.0101: efficiency and site-selectivity of liquid and gaseous nitrating agents.
Q37784821Nitric Oxide Signaling and Nitrosative Stress in Neurons: Role forS-Nitrosylation
Q24645400Nitric oxide and peroxynitrite in health and disease
Q34658870Nitric oxide and peroxynitrite interactions with mitochondria
Q36482571Nitric oxide as a cellular antioxidant: a little goes a long way.
Q36018261Nitric oxide as a regulator of B. anthracis pathogenicity
Q42468375Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling
Q41832099Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration.
Q48583157Nitric oxide signals postovulatory aging-induced abortive spontaneous egg activation in rats.
Q37356224Nitric oxide, oxidants, and protein tyrosine nitration
Q34725803Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin
Q37887771Nitric oxide: a guardian for vascular grafts?
Q34615863Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.
Q89498915Nitroxidized-Albumin Advanced Glycation End Product and Rheumatoid Arthritis
Q44018831Nitroxyl (NO-): a substrate for superoxide dismutase
Q37014196Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury: a comprehensive review
Q46818546Opposite effects of pre- and postischemic treatments with nitric oxide donor on ischemia/reperfusion-induced renal injury
Q37656707Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
Q38209427Oxidation and modification of extracellular matrix and its role in disease
Q53622316Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells.
Q42933830Oxidation of hypotaurine and cysteine sulphinic acid by peroxynitrite
Q50475678Oxidative and nitrative modifications of enkephalins by reactive nitrogen species.
Q43794690Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities
Q44703761Oxidative stress in blood of camels (Camelus dromedaries) naturally infected with Trypanosoma evansi
Q26747626Oxidative-Nitrosative Stress and Myocardial Dysfunctions in Sepsis: Evidence from the Literature and Postmortem Observations
Q35081401Oxygen, early embryonic metabolism and free radical-mediated embryopathies
Q81436451Oxyleghemoglobin scavenges nitrogen monoxide and peroxynitrite: a possible role in functioning nodules?
Q28080057Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP)
Q48133884Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration.
Q36740177Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite
Q37021575Peroxynitrite and nitrosoperoxycarbonate, a tightly connected oxidizing-nitrating couple in the reactive nitrogen-oxygen species family: new perspectives for protection from radical-promoted injury by flavonoids
Q37328701Peroxynitrite and opiate antinociceptive tolerance: a painful reality
Q78659354Peroxynitrite formation from biochemical and cellular fluxes of nitric oxide and superoxide
Q44814157Peroxynitrite formation from the simultaneous reduction of nitrite and oxygen by xanthine oxidase
Q36501612Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins
Q44721735Peroxynitrite inhibits epidermal growth factor receptor signaling in Caco-2 cells.
Q40574996Peroxynitrite mediates nitric oxide-induced blood-brain barrier damage.
Q33943403Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains
Q46459109Peroxynitrite modulates release of inflammatory mediators from guinea pig lung mast cells activated by antigen-antibody reaction
Q28610681Peroxynitrite reactions and formation in mitochondria
Q34809217Peroxynitrite signaling: receptor tyrosine kinases and activation of stress-responsive pathways.
Q35602260Peroxynitrite-dependent modifications of tyrosine residues in hemoglobin. Formation of tyrosyl radical(s) and 3-nitrotyrosine
Q34314724Peroxynitrite-driven mechanisms in diabetes and insulin resistance - the latest advances
Q35099318Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention
Q42918155Peroxynitrite-mediated oxidative modifications of myosin and implications on structure and function.
Q29615424Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Q28073105Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress
Q35858661Poly(ADP-ribosyl)ation inhibitors: promising drug candidates for a wide variety of pathophysiologic conditions
Q38239610Posttranslational protein modifications by reactive nitrogen and chlorine species and strategies for their prevention and elimination
Q58495820Potential Health Effects of Champagne Wine Consumption
Q34117168Potential therapeutic benefits of strategies directed to mitochondria.
Q40631185Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protection
Q45204092Protection by flavonoids against the peroxynitrite-mediated oxidation of dihydrorhodamine
Q37479069Protective effect of metalloporphyrins against cisplatin-induced kidney injury in mice
Q39776366Protective effect of verbascoside in activated C6 glioma cells: possible molecular mechanisms
Q44109970Protective properties of butanolic extract of the Calendula officinalis L. (marigold) against lipid peroxidation of rat liver microsomes and action as free radical scavenger
Q46815401Protein 3-nitrotyrosine formation during Trypanosoma cruzi infection in mice
Q35653222Protein S-nitrosylation: role for nitric oxide signaling in neuronal death
Q37071832Protein nitration in placenta - functional significance
Q35608301Proteomic analysis of age dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry
Q44512885Radical production from free and peptide-bound methionine sulfoxide oxidation by peroxynitrite and hydrogen peroxide/iron(II).
Q39340228Ratiometric Fluorescent Probes for the Detection of Reactive Oxygen Species
Q36472763Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase
Q44550526Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals
Q44406751Reactions of Manganese Porphyrins with Peroxynitrite and Carbonate Radical Anion
Q37342840Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress
Q46612472Reactive nitrogen species formation in eosinophils and imbalance in nitric oxide metabolism are involved in atopic dermatitis-like skin lesions in NC/Nga mice
Q34009236Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver
Q35915428Reactive oxygen species and nitric oxide in cutaneous leishmaniasis.
Q29619367Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
Q38263705Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review
Q37493551Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability
Q37181226Redox regulation of cell survival
Q83812910Reduced fluoresceinamine for peroxynitrite quantification in the presence of nitric oxide
Q45153910Reduction of lipid peroxidation and apoptosis in corneal endothelial cells by vitamin A
Q36546362Regulation of Ras proteins by reactive nitrogen species
Q35659224Regulation of prostate cancer cell invasion by modulation of extra- and intracellular redox balance
Q44618100Relationship between protein nitration and oxidation and development of hyperoxic seizures
Q36399993Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury
Q35689391Resistance of Francisella tularensis strains against reactive nitrogen and oxygen species with special reference to the role of KatG.
Q34108098Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite
Q50679885Reversal of neurobehavioral and neurochemical alterations in STZ-induced diabetic rats by FeTMPyP, a peroxynitrite decomposition catalyst and 1,5-Isoquinolinediol a poly(ADP-ribose) polymerase inhibitor.
Q39762460Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation.
Q38062351Role of peroxynitrite-modified biomolecules in the etiopathogenesis of systemic lupus erythematosus.
Q40387269Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages
Q45045293Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition.
Q33584490Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis
Q36529803Sources and targets of reactive oxygen species in synaptic plasticity and memory
Q58271993Spectrophotometric Determination of Peroxynitrite Usingo‐Phenylenediamine as a Probe
Q59305141Spirodiazaselenuranes: synthesis, structure and antioxidant activity
Q35609538Strategies for reducing or preventing the generation of oxidative stress
Q85633103Substituent effects on the stability and antioxidant activity of spirodiazaselenuranes
Q37276209Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers
Q43832674Synaptosomal plasma membrane Ca(2+) pump activity inhibition by repetitive micromolar ONOO(-) pulses
Q92377476TEMPOL has limited protective effects on renal oxygenation and hemodynamics but reduces kidney damage and inflammation in a rat model of renal ischemia/reperfusion by aortic clamping
Q44225798TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney
Q50658306TNF-alpha potentiates protein-tyrosine nitration through activation of NADPH oxidase and eNOS localized in membrane rafts and caveolae of bovine aortic endothelial cells.
Q37391065Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage
Q46315162The Interaction of Hypotaurine and Other Sulfinates with Reactive Oxygen and Nitrogen Species: A Survey of Reaction Mechanisms.
Q44086462The NADH oxidase activity of the plasma membrane of synaptosomes is a major source of superoxide anion and is inhibited by peroxynitrite
Q35977855The neglected significance of "antioxidative stress".
Q34131871The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes
Q47255263The persistence and photostabilizing characteristics of benzotriazole and 5-methyl-1H-benzotriazole reduce the photochemical behavior of common photosensitizers and organic compounds in aqueous environments
Q46780305The preparation and purification of NO gas and the use of NO releasers: the application of NO donors and other agents of nitrosative stress in biological systems
Q38241541The protective role of antioxidants in the defence against ROS/RNS-mediated environmental pollution
Q24632308The roles of nitric oxide synthase and eIF2alpha kinases in regulation of cell cycle upon UVB-irradiation
Q44004924The usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin
Q46367827Thiomaleimide Functionalization for Selective Biological Fluorescence Detection of Peroxynitrite as Tested in HeLa and RAW 264.7 Cells
Q46396688Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury
Q24289511Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples
Q31049612Tyrosine nitration impairs mammalian aldolase A activity
Q30389594Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects.
Q44089720Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity
Q51552421Urinary kidney injury molecules in children with febrile seizures.
Q36396193Use of fluorescence probes for detection of reactive nitrogen species: a review.
Q46090168Volatile interface of biological oxidant and luminescent CdTe quantum dots: implications in nanodiagnostics
Q26995028What really happens in the neutrophil phagosome?
Q36751411X-ray absorption spectroscopic characterization of a cytochrome P450 compound II derivative
Q34790915Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme.
Q38960585¹⁹F magnetic resonance probes for live-cell detection of peroxynitrite using an oxidative decarbonylation reaction.

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