Visualizing the mechanical activation of Src.

scientific article

Visualizing the mechanical activation of Src. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1014979242
P356DOI10.1038/NATURE03469
P698PubMed publication ID15846350
P5875ResearchGate publication ID7891937

P2093author name stringMichael W Berns
Roger Y Tsien
Elliot L Botvinick
Shu Chien
Yingxiao Wang
Shunichi Usami
Yihua Zhao
P2860cites workWAVE, a novel WASP-family protein involved in actin reorganization induced by RacQ22008483
Src kinase activation by direct interaction with the integrin β cytoplasmic domainQ24298960
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complexQ24301883
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinasesQ24316242
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanismQ24679102
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptidesQ27642117
The molecular structure of green fluorescent proteinQ27758957
The green fluorescent proteinQ27860492
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talinQ28505684
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cellsQ29547331
Cellular functions regulated by Src family kinasesQ29616038
Catalytic specificity of protein-tyrosine kinases is critical for selective signallingQ29616451
Integrin function: molecular hierarchies of cytoskeletal and signaling moleculesQ29618843
Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activityQ30167760
The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinaseQ30168835
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cellsQ30857023
Focal adhesions - the cytoskeletal connectionQ33840319
Tensegrity II. How structural networks influence cellular information processing networksQ35086156
Direct observations of the mechanical behaviors of the cytoskeleton in living fibroblastsQ36288358
Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src.Q40918530
Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130CasQ41198387
Force-induced focal adhesion translocation: effects of force amplitude and frequency.Q42462879
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membraneQ42823071
Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesionsQ42830232
Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cellsQ45289473
HIF1A signaling selectively supports proliferation of breast cancer in the brainQ56883100
Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: dissection of the phosphopeptide sequence specificity and coupling energeticsQ77357850
Highly efficient green fluorescent protein-based kinase substratesQ77795750
P433issue7036
P407language of work or nameEnglishQ1860
P921main subjectvisualizationQ451553
P304page(s)1040-1045
P577publication date2005-04-01
P1433published inNatureQ180445
P1476titleVisualizing the mechanical activation of Src.
P478volume434

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cites work (P2860)
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Q35945748Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice
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Q42359515Participation of caveolae in beta1 integrin-mediated mechanotransduction
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Q41637099Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation
Q36427519Phosphotyrosine recognition domains: the typical, the atypical and the versatile
Q55347878Photonic force optical coherence elastography for three-dimensional mechanical microscopy.
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Q54720891Quantifying the mechanical micro-environment during three-dimensional cell expansion on microbeads by means of individual cell-based modelling.
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Q37582153Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo
Q28471902Rapid activation of Rac GTPase in living cells by force is independent of Src
Q36638646Rapid signal transduction in living cells is a unique feature of mechanotransduction.
Q34663332Real-time calcium measurements of live optically trapped microorganisms
Q35216830Real-time observation of flow-induced cytoskeletal stress in living cells
Q47625174Receptor-mediated cell mechanosensing.
Q39280426Red-shifted fluorescent proteins monitor enzymatic activity in live HT-1080 cells with fluorescence lifetime imaging microscopy (FLIM).
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Q35931375Regulation of Epithelial-Mesenchymal Transition by Transmission of Mechanical Stress through Epithelial Tissues
Q42546805Regulation of cancer invasiveness by the physical extracellular matrix environment
Q47433774Regulation of genome organization and gene expression by nuclear mechanotransduction
Q34391396Regulation of myogenic activation of p38 MAPK by TACE-mediated TNFα release
Q56809927Removing physiological motion from intravital and clinical functional imaging data
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Q30597529RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.
Q41950141RhoA goes GLOBAL
Q55665055Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.
Q28484914SRC kinase regulation in progressively invasive cancer
Q35808753Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
Q34670411Seeing is believing: peptide-based fluorescent sensors of protein tyrosine kinase activity
Q54340814Selective regulation of cytoskeletal tension and cell-matrix adhesion by RhoA and Src.
Q42443366Shear Stress Activates eNOS at the Endothelial Apical Surface Through β1 Containing Integrins and Caveolae
Q42015709Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-κB Pathway Via Actin and Tyrosine Kinases
Q36269821Shining light on signaling and metabolic networks by genetically encoded biosensors.
Q39663555Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.
Q64117163Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus
Q38235814Single-cell imaging of mechanotransduction in endothelial cells
Q38694712Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles.
Q39192915Smart mechanosensing machineries enable migration of vascular smooth muscle cells in atherosclerosis-relevant 3D matrices.
Q27318726Smooth muscle tension induces invasive remodeling of the zebrafish intestine
Q37780682Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis
Q28391160Spatiotemporal regulation of Src and its substrates at invadosomes
Q35906584Spermine, a molecular switch regulating EGFR, integrin β3, Src, and FAK scaffolding
Q37201493Src mediates the mechanical activation of myogenesis by activating TNFα-converting enzyme
Q36443416Src, p130Cas, and Mechanotransduction in Cancer Cells
Q47195448Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity.
Q52735729Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila.
Q36729804Stiffened lipid platforms at molecular force foci
Q42053421Stimulus-specific distinctions in spatial and temporal dynamics of stress-activated protein kinase kinase kinases revealed by a fluorescence resonance energy transfer biosensor
Q37038056Strange dynamics of a dynamic cytoskeleton
Q100385808Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
Q37779877Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing
Q59356594Strong cytoskeleton activity on millisecond timescales upon particle binding revealed by ROCS microscopy
Q51030745Study of subcellular dynamics on cell-substrate interactions by live cell imaging.
Q30660640Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment
Q41489885Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling
Q37378697Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK.
Q39731271Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility
Q35036534Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
Q44402556TNFα shedding in mechanically stressed cardiomyocytes is mediated by Src activation of TACE.
Q48561386Teaching resources. Imaging signal transduction in living cells with fluorescent proteins
Q57497858Techniques to stimulate and interrogate cell-cell adhesion mechanics
Q31031682Temporal Data Set Reduction Based on D-Optimality for Quantitative FLIM-FRET Imaging
Q38981265The 2016 John J. Abel Award Lecture: Targeting the Mechanical Microenvironment in Cancer
Q48049802The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.
Q97067101The Importance of Mechanical Forces for in vitro Endothelial Cell Biology
Q27318175The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells
Q54110383The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamber.
Q24620636The chemical biology of protein phosphorylation
Q34981407The effect of differentiation induction on FAK and Src activity in live HMSCs visualized by FRET.
Q37869980The emerging role of forces in axonal elongation.
Q34693155The focal adhesion: a regulated component of aortic stiffness
Q27346726The interplay of cell-cell and cell-substrate adhesion in collective cell migration
Q47348135The position and size of individual focal adhesions are determined by intracellular stress-dependent positive regulation
Q30652136The primary cilium functions as a mechanical and calcium signaling nexus
Q33729093The reactive oxygen species–Src–Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high‐fluence low‐power laser irradiation
Q41956838The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation
Q27336443The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging
Q42798961Three-dimensional microfiber devices that mimic physiological environments to probe cell mechanics and signaling
Q35153270Time-resolved digital holographic microscopy of laser-induced forward transfer process
Q38756147Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation
Q30429589To pull or be pulled: parsing the multiple modes of mechanotransduction
Q42457387Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle
Q45987365Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.
Q34592788Tropomyosin Tm5NM1 spatially restricts src kinase activity through perturbation of Rab11 vesicle trafficking
Q50645236Tunable AICPL of (S)-Binaphthyl-Based Three-Component Polymers via FRET Mechanism
Q30501006Two distinct phases of calcium signalling under flow
Q30424653Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region.
Q42015041Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins
Q27438112Understanding sensory nerve mechanotransduction through localized elastomeric matrix control
Q38062577Using FRET to analyse signals controlling cell adhesion and migration
Q42751888Using a genetically encoded FRET-based reporter to visualize calcineurin phosphatase activity in living cells
Q42141595VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells
Q36909070Visualization of Compartmentalized Kinase Activity Dynamics Using Adaptable BimKARs
Q30486173Visualization of Src activity at different compartments of the plasma membrane by FRET imaging.
Q28482181Visualization of Src and FAK activity during the differentiation process from HMSCs to osteoblasts
Q37111239Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer
Q30482313Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging
Q41570591Visualizing Tyrosine Kinase Activity with Bipartite Tetracysteine Display
Q37202389Visualizing and quantifying adhesive signals
Q42052139Visualizing the effect of microenvironment on the spatiotemporal RhoA and Src activities in living cells by FRET
Q50641660Xenopus oocyte plasma membrane sheets for FRET analysis
Q42877307c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategy
Q33347804mRNA display selection of a high-affinity, modification-specific phospho-IkappaBalpha-binding fibronectin
Q37076166miRNA-548c: a specific signature in circulating PBMCs from dilated cardiomyopathy patients
Q41834030β Integrins mediate FAK Y397 autophosphorylation of resistance arteries during eutrophic inward remodeling in hypertension

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