Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse

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Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0065-2776(05)87004-X
P8608Fatcat IDrelease_zxc6x3aoyzaupjdeamrb3w3mim
P698PubMed publication ID16102573

P2093author name stringKathryn Haskins
P2860cites workIdentification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.Q24679680
Mimotopes for alloreactive and conventional T cells in a peptide-MHC display libraryQ24804498
Integrins: bidirectional, allosteric signaling machinesQ27860700
Integrins: versatility, modulation, and signaling in cell adhesionQ27860844
Interleukin-17 family and IL-17 receptorsQ28185677
Phenotypic analysis of antigen-specific T lymphocytesQ28290058
Preferential production of interferon-gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7Q28367021
Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranesQ28583729
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cellsQ28585061
Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related proteinQ28589562
A diabetes-associated T-cell autoantigen maps to a telomeric locus on mouse chromosome 6.Q30453976
Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic miceQ30644510
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.Q30763625
T cell response to preproinsulin I and II in the nonobese diabetic mouseQ30844663
Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clonesQ30872028
Tracking autoimmune T cells in diabetesQ30982114
Autoantibodies and CD4 T cells target a beta cell retroviral envelope protein in non-obese diabetic miceQ31029592
Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinaseQ31131014
Increased islet antigen presentation leads to type-1 diabetes in mice with autoimmune susceptibilityQ47867708
T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetesQ47872045
Single-cell analysis of the murine chemokines MIP-1alpha, MIP-1beta, RANTES and ATAC/lymphotactin by flow cytometry.Q52952880
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.Q55066037
Identification of a -Cell-Specific HLA Class I Restricted Epitope in Type 1 DiabetesQ58328327
Progression of autoimmune diabetes driven by avidity maturation of a T-cell populationQ58328335
T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteinsQ59072743
Following a diabetogenic T cell from genesis through pathogenesisQ70488192
Bone marrow abnormalities in the non-obese diabetic mouseQ70608733
Organ-specific disease provoked by systemic autoimmunityQ71838378
T helper cell subsets in insulin-dependent diabetesQ72265872
An islet-homing NOD CD8+ cytotoxic T cell clone recognizes GAD65 and causes insulitisQ73174046
Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetesQ73397999
GAD-about BDC2.5: Peptides that stimulate BDC2.5 T cells and inhibit IDDMQ73407927
Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functionsQ73567384
A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic miceQ73896300
Biochemical characterization of a beta cell membrane fraction antigenic for autoreactive T cell clonesQ73958439
Genetic control of diabetes progressionQ74045636
Nondepleting anti-CD4 has an immediate action on diabetogenic effector cells, halting their destruction of pancreatic beta cellsQ74108273
Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetesQ77192908
Islet cell membrane antigens activate diabetogenic CD4+ T-cells in the BB/Wor ratQ77759108
Cellular and molecular changes accompanying the progression from insulitis to diabetesQ77952302
Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplantsQ78060357
Low expression of insulin in the thymus of non-obese diabetic miceQ78631903
Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transferQ80475644
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetesQ46512140
Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides.Q47564253
Ex Vivo Analysis of Thymic CD4 T Cells in Nonobese Diabetic Mice with Tetramers Generated from I-Ag7/Class II-Associated Invariant Chain Peptide PrecursorsQ47581749
Chemokines and T lymphocytes: more than an attractionQ47713299
Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypicalQ31839049
Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)Q33592891
Regional specialization in the mucosal immune system: primed cells do not always home along the same trackQ33650461
Lymphocyte trafficking and regional immunity.Q33653665
Dissecting the role of CD4+ T cells in autoimmune diabetes through the use of TCR transgenic miceQ33713280
IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytesQ33938806
Nanoscale organization of multiple GPI-anchored proteins in living cell membranes.Q33976149
Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitusQ34025467
MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokinesQ34028418
It's insulinQ34065086
Lymphocyte traffic control by chemokinesQ34139610
Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localizationQ34219488
Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAsQ34231532
T-cell receptor transgenic mice in the study of autoimmune diseasesQ34301532
Pancreatic islet-specific T-cell clones from nonobese diabetic miceQ34313103
The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.Q34452348
Expanding complexity in myotonic dystrophyQ34485468
Cytokines and autoimmunityQ34572227
Tracking T cells with tetramers: new tales from new toolsQ34632077
Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.Q34768674
Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral bloodQ34830048
T-cell activation: a multidimensional signaling network.Q34858190
Autoreactive T cells in endocrine/organ-specific autoimmunity: why has progress been so slow?Q35034684
MHC multimers: expanding the clinical toolkit.Q35065291
Antigen-induced T1D in NOD miceQ35130073
A comprehensive guide to antibody and T-cell responses in type 1 diabetes.Q35583448
Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetesQ35602903
Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis?Q35675887
T-cell receptor transgenic (TCR-Tg) mice from two diabetogenic CD4+ islet-antigen-specific T-cell clonesQ35677342
T-cell receptor-transgenic NOD mice: a reductionist approach to understand autoimmune diabetesQ35677353
Integrins and T cell-mediated immunityQ35698435
Beta cell apoptosis in T cell-mediated autoimmune diabetesQ35905815
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivityQ35919777
T cell receptor restriction of diabetogenic autoimmune NOD T cellsQ36049067
The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's diseaseQ36173253
T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic miceQ36230116
Ly-6C regulates endothelial adhesion and homing of CD8(+) T cells by activating integrin-dependent adhesion pathwaysQ36242077
Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.Q36353954
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.Q36366075
Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodesQ36367942
In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha.Q36368009
Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells.Q36370525
A mechanism for the major histocompatibility complex-linked resistance to autoimmunityQ36380664
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic miceQ36380895
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetesQ36400199
Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangementQ36526326
The identification of CD4+ T cell epitopes with dedicated synthetic peptide librariesQ36586011
Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD miceQ36678330
Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD miceQ36736666
Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetesQ36796917
Peripheral T cell clones from NOD mice specific for GAD65 peptides: lack of islet responsiveness or diabetogenicityQ36820923
T Cell Receptor Gene Polymorphisms Associated with Anti-Insulin, Autoimmune T Cells in Diabetes-Prone NOD MiceQ36870393
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetesQ37114100
Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreasQ37263532
GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.Q37376906
Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic miceQ37384851
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitusQ37518209
Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.Q37548447
The insulin secretory granuleQ38255435
HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetesQ40581535
Ly6C induces clustering of LFA-1 (CD11a/CD18) and is involved in subtype-specific adhesion of CD8 T cellsQ40675952
MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activityQ40790715
Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct V beta genesQ40826705
Induction of diabetes in nonobese diabetic mice by Th2 T cell clones from a TCR transgenic mouseQ40895338
CD8 cytotoxic T-cell clone rapidly transfers autoimmune diabetes in very young NOD and MHC class I-compatible scid miceQ41090515
Adhesion molecules in autoimmune diseaseQ41133422
HLA-DR-restricted T cell lines from newly diagnosed type 1 diabetic patients specific for insulinoma and normal islet beta cell proteins: lack of reactivity to glutamic acid decarboxylaseQ41291890
Autoreactive T-cell clones from the nonobese diabetic mouseQ41333085
T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouseQ43687826
Paralytic autoimmune myositis develops in nonobese diabetic mice made Th1 cytokine-deficient by expression of an IFN-gamma receptor beta-chain transgeneQ44040421
Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic miceQ44207015
Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell cloneQ44534362
Autoimmune diabetes and the circle of toleranceQ44745115
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetesQ44903844
T cells with multiple fine specificities are used by non-obese diabetic (NOD) mice in the response to GAD(524-543).Q46506956
P304page(s)123-162
P577publication date2005-01-01
P1433published inAdvances in ImmunologyQ15752932
P1476titlePathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse
P478volume87

Reverse relations

cites work (P2860)
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