Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

scientific article published on July 1991

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1991PNAS...88.6167C
P356DOI10.1073/PNAS.88.14.6167
P932PMC publication ID52043
P698PubMed publication ID2068098
P5875ResearchGate publication ID21088128

P50authorJonathan D. KatzQ57140999
Serge M CandéiasQ57770309
P2093author name stringC Benoist
K Haskins
D Mathis
P2860cites workPancreatic islet-specific T-cell clones from nonobese diabetic miceQ34313103
The structure of V alpha and J alpha segments in the mouseQ36077529
The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptidesQ36351944
T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clonesQ36352443
Restricted V-segment usage in T-cell receptors from cytotoxic T lymphocytes specific for a major epitope of lymphocytic choriomeningitis virusQ36796002
Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant miceQ36840517
The T lymphocyte in experimental allergic encephalomyelitisQ37925549
Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat.Q37925551
The T-cell receptor repertoire and autoimmune diseasesQ38201553
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapyQ39272381
Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene familiesQ39485419
Identification and characterization of new murine T cell receptor beta chain variable region (V beta) genesQ41814249
Vaccination against experimental allergic encephalomyelitis with T cell receptor peptidesQ43794379
Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell cloneQ44534362
Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitisQ45351794
Preferential usage of V alpha 4 and V beta 10 T cell receptor genes by lymphocytic choriomeningitis virus glycoprotein-specific H-2Db-restricted cytotoxic T cellsQ45852082
Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patientsQ46081307
T-lymphocyte clone specific for pancreatic islet antigenQ46335815
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune interventionQ46499427
The T cell receptor V alpha 3 gene segment is associated with reactivity to p-azobenzenearsonateQ48319186
Receptor diversity of insulin-specific T cell lines from C57BL (H-2b) mice.Q48344016
Correlations between T-cell specificity and the structure of the antigen receptorQ48365072
Dominance of one T-cell receptor in the H–2Kb/TNP responseQ58968930
An explanation for the protective effect of the MHC class II I–E molecule in murine diabetesQ59081580
MHC-linked protection from diabetes dissociated from clonal deletion of T cellsQ68344478
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)6167-6170
P577publication date1991-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIslet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors
P478volume88

Reverse relations

cites work (P2860)
Q70722241A comparative study of T-cell receptor V beta usage in non-obese diabetic (NOD) and I-E transgenic NOD mice
Q30311456A protective NOD islet-infiltrating CD8+ T cell clone, I.S. 2.15, has in vitro immunosuppressive properties
Q56880557Analysis of the Peripheral T-Cell Receptor VP Repertoire in Newly Diagnosed Patients with Type I Diabetes
Q34517586Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage
Q36365696CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice
Q40787110Cellular basis of T-cell autoreactivity in autoimmune diseases
Q41859484Characterization of the T cell receptor repertoire causing collagen arthritis in mice
Q36365722Dual T cell receptor alpha chain T cells in autoimmunity
Q72788288Effect of T-cell receptor V beta-specific monoclonal antibodies on cyclophosphamide-induced diabetes mellitus in non-obese diabetic mice
Q63952511Efficient immune responses in mice lacking N-region diversity
Q33715004Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
Q36231586Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes
Q52882904Evidence for a preferential V beta usage by the T cells which adoptively transfer diabetes in NOD mice.
Q59060541Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
Q52025010High density insulin receptor-positive diabetogenic T lymphocytes in nonobese diabetic mice are memory cells.
Q35022826High-throughput sequencing of islet-infiltrating memory CD4+ T cells reveals a similar pattern of TCR Vβ usage in prediabetic and diabetic NOD mice
Q46408296High-throughput sequencing reveals restricted TCR Vβ usage and public TCRβ clonotypes among pancreatic lymph node memory CD4(+) T cells and their involvement in autoimmune diabetes
Q37114342Hydrophobic CDR3 residues promote the development of self-reactive T cells
Q43147458Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients
Q36367689Immunization with soluble BDC 2.5 T cell receptor-immunoglobulin chimeric protein:antibody specificity and protection of nonobese diabetic mice against adoptive transfer of diabetes by maternal immunization
Q50896247Individuals from multiplex insulin-dependent diabetes mellitus (IDDM) families express higher levels of TCRBV2S1 than controls.
Q52207566Induction of diabetes with islet-specific T-cell clones is age dependent.
Q72035895Infiltrating T cells from patients with primary Sjögren's syndrome express restricted or unrestricted T cell receptor V beta regions depending on the stage of the disease
Q36377306Influence of the NH2-terminal amino acid of the T cell receptor alpha chain on major histocompatibility complex (MHC) class II + peptide recognition
Q36400215Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities
Q38691482Mechanisms of autoimmunity in the non-obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation
Q38660197Mechanisms of diabetic autoimmunity: I--the inductive interface between islets and the immune system at onset of inflammation
Q38611317Mechanisms of diabetic autoimmunity: II--Is diabetes a central or peripheral disorder of effector and regulatory cells?
Q44958053Monoclonal T cells identified in early NOD islet infiltrates
Q42651261N-terminal flanking residues of a diabetes-associated GAD65 determinant are necessary for activation of antigen-specific T cells in diabetes-resistant mice
Q35646174Non-obese diabetic transgenic mouse
Q39264408Nuclear transferred embryonic stem cells for analysis of B1 B-lymphocyte development
Q71838378Organ-specific disease provoked by systemic autoimmunity
Q33221766Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse
Q40066064Predominant use of a T-cell receptor V beta gene family in simian immunodeficiency virus Gag-specific cytotoxic T lymphocytes in a rhesus monkey
Q35602903Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetes
Q37305242Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny
Q36970573Regulation of autoimmunity
Q34035323Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice
Q42611081Shared structural motifs in TCR of glycopeptide-recognizing T cell hybridomas
Q41534929Suppression of diabetes mellitus in the non-obese diabetic (NOD) mouse by an autoreactive (anti-I-Ag7) islet-derived CD4+ T-cell line
Q35919777Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
Q36870393T Cell Receptor Gene Polymorphisms Associated with Anti-Insulin, Autoimmune T Cells in Diabetes-Prone NOD Mice
Q37174434T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses
Q33805895T cell receptor gene usage in autoimmune diabetes
Q36049067T cell receptor restriction of diabetogenic autoimmune NOD T cells
Q83205902T cells to a dominant epitope of GAD65 express a public CDR3 motif
Q40465758T-cell receptor use in organ-specific human autoimmune diseases other than rheumatoid arthritis and multiple sclerosis. Summary and overview.
Q35654189T-lymphocytes and the pathogenesis of type 1 (insulin-dependent) diabetes mellitus
Q40878852The immunologic insult in type 1 diabetes
Q52225294The level of N-region diversity in T cell receptors is not pre-ordained in the stem cell.
Q36375353The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope
Q40433231Tolerance Induction as a Therapeutic Strategy for the Control of Autoimmune Endocrine Disease in Mouse Models

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