Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity

scientific article published in September 2003

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI18337
P932PMC publication ID193666
P698PubMed publication ID12975475

P50authorChristophe BenoistQ87765385
P2093author name stringDiane Mathis
Hitoshi Kikutani
Kenji Yoshida
Michael B A Oldstone
Luc Teyton
Kathryn Haskins
Grigoriy Losyev
Thomas Stratmann
Natalia Martin-Orozco
Laurent Poirot
Cathleen M Dobbs
Dorian McGavern
Valérie Mallet-Designe
P2860cites workEstimating the precursor frequency of naive antigen-specific CD8 T cellsQ24674109
A structural framework for deciphering the link between I-Ag7 and autoimmune diabetesQ27622298
Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD miceQ27625365
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetesQ27632133
Phenotypic analysis of antigen-specific T lymphocytesQ28290058
T-cell antigen receptor genes and T-cell recognitionQ29619721
Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic miceQ30644510
Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clonesQ30872028
Molecular basis for recognition of an arthritic peptide and a foreign epitope on distinct MHC molecules by a single TCR.Q30872493
The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binderQ30919440
Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reactionQ32123429
Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallizationQ33731073
Delineation of antigen contact residues on an MHC class II moleculeQ33923511
Pancreatic islet-specific T-cell clones from nonobese diabetic miceQ34313103
Following a diabetogenic T cell from genesis through pathogenesisQ70488192
The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide bindersQ70843994
Insulin-dependent diabetes mellitusQ71046915
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic miceQ71641038
Organ-specific disease provoked by systemic autoimmunityQ71838378
Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetesQ73014358
Arthritis provoked by linked T and B cell recognition of a glycolytic enzymeQ73216181
Genetic control of diabetes progressionQ74045636
A defect in central tolerance in NOD miceQ74825850
Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetesQ77192908
Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensorsQ77338435
A new look at MHC and autoimmune diseaseQ77771995
Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7Q77801073
Genetic protection from the inflammatory disease type 1 diabetes in humans and animal modelsQ34376868
The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.Q34452348
The first external domain of the nonobese diabetic mouse class II I-A beta chain is uniqueQ34614636
The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoireQ35602289
T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic miceQ36230116
Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.Q36364198
Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II moleculesQ36366719
Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodesQ36367942
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic miceQ36380895
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetesQ36400199
Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD miceQ36678330
Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: a 13 residue consensus peptide specifies biotinylation in Escherichia coli.Q36705248
Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivoQ36787434
Massive expansion of antigen-specific CD8+ T cells during an acute virus infectionQ37419599
Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.Q37548447
Checkpoints in the progression of autoimmune disease: lessons from diabetes modelsQ37689425
Cutting edge: In situ tetramer staining of antigen-specific T cells in tissuesQ38464540
Genetic Control of Specific Immune ResponsesQ39988595
Genetic control of autoimmune diabetes in the NOD mouseQ40444847
Antigen-selected T-cell receptor diversity and self-nonself homologyQ40858305
Genetic analysis of autoimmune diseaseQ40980040
The search for IDDM susceptibility genes: the next generationQ40981935
Islet-specific T-cell clones from the NOD mouse respond to beta-granule antigenQ41489831
Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicityQ41605782
Islet-infiltrating T cell clones from non-obese diabetic mice that promote or prevent accelerated onset diabetesQ41689049
The microbial product lipopolysaccharide confers diabetogenic potential on the T cell repertoire of BDC2.5/NOD mice: implications for the etiology of autoimmune diabetesQ41731978
Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hostsQ42115050
Tolerance and immunity to the inducible self antigen C-reactive protein in transgenic miceQ42514204
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunityQ43433033
In situ beta cell death promotes priming of diabetogenic CD8 T lymphocytesQ43860764
The NOD mouse: recessive diabetogenic gene in the major histocompatibility complexQ43926964
In situ detection of virus- and tumor-specific T-cell immunityQ44528213
Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell cloneQ44534362
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytesQ44851100
Molecular basis for HLA-DQ associations with IDDM.Q45113087
Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicryQ45754853
Ligand recognition by alpha beta T cell receptorsQ46222293
T-lymphocyte clone specific for pancreatic islet antigenQ46335815
Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunityQ46792549
Size estimate of the alpha beta TCR repertoire of naive mouse splenocytesQ47238652
Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides.Q47564253
Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexesQ47877315
Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung.Q52016711
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.Q52040367
In vitro peptide binding to soluble empty class I major histocompatibility complex molecules isolated from transfected Drosophila melanogaster cells.Q52441433
NOD mice have a generalized defect in their response to transplantation tolerance induction.Q54095945
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)902-914
P577publication date2003-09-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleSusceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
P478volume112

Reverse relations

cites work (P2860)
Q36653684Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells
Q43560921B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes
Q36399063CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
Q37496758CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L.
Q37376821Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice.
Q53851134Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice.
Q36387060Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes
Q37274444Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice.
Q34211374Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3
Q37704508Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice
Q37598701Delineating the role of the HLA-DR4 "shared epitope" in susceptibility versus resistance to develop arthritis
Q37033008Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?
Q40787726Expanding antigen-specific regulatory networks to treat autoimmunity
Q46889094Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
Q42868832Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice
Q36975465Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice
Q36354925Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.
Q36842573Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
Q46630002In situ staining using MHC class I tetramers
Q37714655In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis
Q34527126Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD mice
Q24647312Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Q35405281Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies
Q49790362MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice
Q36403033Modifier loci condition autoimmunity provoked by Aire deficiency
Q33794336Mouse Models for Type 1 Diabetes
Q37593413Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis
Q37018598Novel autoantigens for diabetogenic CD4 T cells in autoimmune diabetes
Q36945852Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Q33221766Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse
Q33527496Peripherin-reactive antibodies in mouse, rabbit, and human blood
Q35062855Population dynamics of islet-infiltrating cells in autoimmune diabetes.
Q67994522Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
Q81075249Soluble, dimeric HLA DR4-peptide chimeras: an approach for detection and immunoregulation of human type-1 diabetes
Q36012386Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice.
Q35702538T-cell epitopes in type 1 diabetes
Q36287467Tetramer analysis of human autoreactive CD4-positive T cells
Q27660688The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity
Q37187340The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
Q37968302The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding
Q36287487The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection
Q30982114Tracking autoimmune T cells in diabetes
Q55224664Treatment of T1D via optimized expansion of antigen-specific Tregs induced by IL-2/anti-IL-2 monoclonal antibody complexes and peptide/MHC tetramers.
Q35651667Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes
Q36756575Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice
Q28506933Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

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