Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

scientific article

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1110/PS.051936406
P932PMC publication ID2242494
P698PubMed publication ID16600963
P5875ResearchGate publication ID7178778

P2093author name stringYi Li
Feng Gao
Ruth Moysey
Tara Mahon
Brian Cameron
Bent K Jakobsen
Pierre J Rizkallah
Steven M Dunn
Emma Baston
Malkit Sami
Jonathan Boulter
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Positive and negative selection of T cellsQ34157557
The specificity of TCR/pMHC interactionQ34493013
Presentation of a self-peptide in two distinct conformations by a disease-associated HLA-B27 subtypeQ35634203
T cell receptors: affinities, cross-reactivities, and a conformer modelQ35704672
Negative selection imparts peptide specificity to the mature T cell repertoireQ36161289
High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological diseaseQ36361794
Modulation of promiscuous T cell receptor recognition by mutagenesis of CDR2 residuesQ36366710
Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.Q36368633
Structural and kinetic basis for heightened immunogenicity of T cell vaccinesQ36403443
HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptidesQ36954248
Exogenous peptides presented by transporter associated with antigen processing (TAP)-deficient and TAP-competent cells: intracellular loading and kinetics of presentationQ40785567
Identification of NY-ESO-1 peptide analogues capable of improved stimulation of tumor-reactive CTL.Q40870242
Biophysical studies of T-cell receptors and their ligandsQ41053752
Peptide-dependent expression of HLA-B7 on antigen processing-deficient T2 cellsQ41198807
Two-step binding mechanism for T-cell receptor recognition of peptide MHC.Q42050788
Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand bindingQ42153770
The architecture of metal coordination groups in proteinsQ44855091
Ligand recognition by alpha beta T cell receptorsQ46222293
The T cell repertoire may be biased in favor of MHC recognition.Q48356651
Directed evolution of human T-cell receptors with picomolar affinities by phage display.Q51538190
Stable, soluble T-cell receptor molecules for crystallization and therapeuticsQ51812335
How the T Cell Repertoire Becomes Peptide and MHC SpecificQ56922033
Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognitionQ74545050
A very high level of crossreactivity is an essential feature of the T-cell receptorQ77324273
TCR binding to peptide-MHC stabilizes a flexible recognition interfaceQ77328526
A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screeningQ24564781
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptorQ27618536
CDR3 loop flexibility contributes to the degeneracy of TCR recognitionQ27640417
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2Q27733853
Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acidsQ27757472
Shape complementarity at protein/protein interfacesQ27860963
Implementation of molecular replacement in AMoReQ27861032
The CCP4 suite: programs for protein crystallographyQ27861090
The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytesQ28139460
T-cell antigen receptor genes and T-cell recognitionQ29619721
In vitro evolution of a T cell receptor with high affinity for peptide/MHC.Q30861962
Specificity and degeneracy of T cellsQ33199993
High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3.Q33211089
Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallizationQ33731073
P433issue4
P921main subjectdirected evolutionQ440681
phage displayQ896217
P304page(s)710-721
P577publication date2006-04-01
P1433published inProtein ScienceQ7251445
P1476titleDirected evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity
P478volume15

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