Human immunodeficiency virus impairs reverse cholesterol transport from macrophages

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Human immunodeficiency virus impairs reverse cholesterol transport from macrophages is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.0040365
P932PMC publication ID1629034
P698PubMed publication ID17076584
P5875ResearchGate publication ID6719136

P50authorYuri V BobryshevQ88065781
Michael BukrinskyQ92173385
Anthony M DartQ37841500
P2093author name stringDmitri Sviridov
Nigora Mukhamedova
Ying Fu
Jan M Orenstein
Tatiana Pushkarsky
Matthew P Morrow
Honor Rose
Larisa Dubrovsky
Zahedi Mujawar
P2860cites workEndocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef proteinQ22251058
Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy.Q50763481
HIV-1 Nef-Induced Upregulation of DC-SIGN in Dendritic Cells Promotes Lymphocyte Clustering and Viral SpreadQ56795509
HIV-1 Nef disrupts antigen presentation early in the secretory pathwayQ64379019
Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern BQ70666068
Efflux of cellular cholesterol and phospholipid to apolipoprotein A-I mutantsQ71903339
Cell proliferation is not required for productive HIV-1 infection of macrophagesQ73435133
Serine phosphorylation-independent downregulation of cell-surface CD4 by nefQ22251290
Apolipoprotein specificity for lipid efflux by the human ABCAI transporterQ24290771
Mechanism for down-regulation of CD28 by Nef.Q24291079
The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier diseaseQ24306475
AtherosclerosisQ24644573
Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomesQ28589822
Ritonavir increases the level of active ADD-1/SREBP-1 protein during adipogenesisQ31643030
Do protease inhibitors increase the risk for coronary heart disease in patients with HIV-1 infection?Q33184007
Abnormal lipids and the acquired immunodeficiency syndrome: is there a problem and what should we do about it?Q33691904
Tangier disease and ABCA1.Q33927615
Plasma membrane rafts play a critical role in HIV-1 assembly and releaseQ33950207
Microorganisms in the aetiology of atherosclerosis.Q34065709
ABCA1. The gatekeeper for eliminating excess tissue cholesterol.Q34325121
Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalizationQ34348930
Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motifQ34353332
Do pathogens accelerate atherosclerosis?Q34389205
Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosisQ34443506
Nef: agent of cell subversionQ34552824
Evidence for infectious agents in cardiovascular disease and atherosclerosisQ34562273
HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterolQ34648356
Cardiovascular manifestations of HIV infectionQ34832031
Consequences of altered isoprenylation targets on a-factor export and bioactivityQ35038534
Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virionsQ35168397
Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the hostQ35753611
Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytesQ35842465
Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytesQ36354762
Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophagesQ36470857
Foam cell formation inhibits growth of Chlamydia pneumoniae but does not attenuate Chlamydia pneumoniae-induced secretion of proinflammatory cytokinesQ37872007
ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activityQ38363238
HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophagesQ39740926
Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.Q39880513
A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomesQ40410574
Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophagesQ40497096
Cyclosporin A traps ABCA1 at the plasma membrane and inhibits ABCA1-mediated lipid efflux to apolipoprotein A-I.Q40516976
Expression of caveolin-1 enhances cholesterol efflux in hepatic cellsQ40598222
Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol MetabolismQ40622775
Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart diseaseQ40677577
Virion-associated cholesterol is critical for the maintenance of HIV-1 structure and infectivity.Q40688664
A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol effluxQ40757234
Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1.Q40788372
ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophagesQ40864882
Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1.Q40864887
HIV-1 Reverse Transcription A Termination Step at the Center of the GenomeQ41443092
Lovastatin inhibits HIV-1 expression in H9 human T lymphocytes cultured in cholesterol-poor mediumQ41506795
Cellular localization and trafficking of the human ABCA1 transporterQ43604836
Use of human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunctionQ43678570
HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemiaQ43811445
Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophagesQ43957626
Structure-function studies of apoA-I variants: site-directed mutagenesis and natural mutations.Q44102355
Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndromeQ44148482
Long-term survival and virus production in human primary macrophages infected by human immunodeficiency virusQ44177453
Decrease in LDL size in HIV-positive adults before and after lopinavir/ritonavir-containing regimen: an index of atherogenicity?Q44430812
Coronary artery disease in HIV infected patientsQ44435381
Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR.Q44460205
Impact of HIV infection and HAART on serum lipids in men.Q44473694
Effects of HIV disease on lipid, glucose and insulin levels: results from a large antiretroviral-naive cohortQ44530878
Cardiovascular risk factors and probability for cardiovascular events in HIV-infected patients: part I. Differences due to the acquisition of HIV-infectionQ44545370
Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).Q44683564
Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infectionQ44801351
ABCA1 expression in carotid atherosclerotic plaques.Q45140725
Viral load of the human immunodeficiency virus could be an independent risk factor for endothelial dysfunctionQ45486626
Acute myocardial infarction in patients infected with human immunodeficiency virusQ45702702
Ischemic cardiovascular disease in persons with human immunodeficiency virus infection.Q45734592
Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector systemQ45746979
Hypocholesterolemia is associated with immune dysfunction in early human immunodeficiency virus-1 infectionQ45788093
ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulationQ46265206
Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactionsQ47863833
Apolipoprotein B-48 or its apolipoprotein B-100 equivalent mediates the binding of triglyceride-rich lipoproteins to their unique human monocyte-macrophage receptorQ47950989
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
macrophageQ184204
P304page(s)e365
P577publication date2006-10-01
P1433published inPLOS BiologyQ1771695
P1476titleHuman immunodeficiency virus impairs reverse cholesterol transport from macrophages.
P478volume4

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