The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model

scientific article

The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/GT.2008.156
P698PubMed publication ID18818669
P5875ResearchGate publication ID23281893

P50authorMartha Campbell-ThompsonQ37381204
P2093author name stringT R Flotte
Q Tang
C Mueller
A T Martino
S A Braag
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Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashionQ45864833
Viral IL-10 gene therapy inhibits TNF-alpha and IL-1 beta, not IL-6, in the newborn endotoxemic mouseQ45877417
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Lung pathology in response to repeated exposure to Staphylococcus aureus in congenic residual function cystic fibrosis mice does not increase in response to decreased CFTR levels or increased bacterial loadQ47855765
Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice.Q51720480
Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice.Q54621653
Multicenter Randomized Controlled Trial of Withdrawal of Inhaled Corticosteroids in Cystic FibrosisQ57913699
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Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosisQ71707597
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Selected abstractsQ73364763
Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gammaQ73843351
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Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cellsQ74012597
IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitroQ77452278
The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10Q77535159
Functional IL-10 deficiency in the lung of cystic fibrosis (cftr(-/-)) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar macrophagesQ77584453
P433issue2
P921main subjectgene therapyQ213901
P304page(s)172-183
P577publication date2008-09-25
P1433published inGene TherapyQ15763095
P1476titleThe pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model
P478volume16

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