Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial

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Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1200/JCO.2007.14.3339
P932PMC publication ID4979080
P698PubMed publication ID19487385

P50authorGianantonio RostiQ66370842
Richard M StoneQ86566342
Andreas HochhausQ37829812
Richard A. LarsonQ41899936
Elisabetta AbruzzeseQ42610677
Jorge Eduardo CortesQ60320900
P2093author name stringJane F Apperley
Hyeoung-Joon Kim
Gail J Roboz
H Jean Khoury
Jeffrey H Lipton
Dong-Wook Kim
Lydia Roy
Timothy P Hughes
Philipp Erben
Christian Sillaber
Eduardo O Bullorsky
Dominik Heim
Carmino A de Souza
Jan Van Tornout
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The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutantsQ28243392
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplificationQ29618788
Overriding imatinib resistance with a novel ABL kinase inhibitorQ30014844
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Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNetQ34567629
Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 studyQ34627586
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice.Q35119075
Role of allogeneic stem cell transplantation for adult chronic myeloid leukemia in the imatinib era.Q36545341
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapyQ38361603
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutantsQ40414595
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.Q40549569
Chronic myelogenous leukemia: a concise updateQ40828907
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 studyQ43904522
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.Q44267685
Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5-year follow-upQ45301057
Survival benefit with imatinib mesylate therapy in patients with accelerated-phase chronic myelogenous leukemia--comparison with historic experienceQ46437707
Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growthQ48192207
Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisisQ53338643
Pleural Effusion in Patients With Chronic Myelogenous Leukemia Treated With Dasatinib After Imatinib FailureQ57731587
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapyQ58023949
Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phaseQ58023953
Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial.Q64911638
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
imatinibQ177094
dasatinibQ419940
chronic myeloid leukemiaQ729735
dasatinib monohydrateQ27139135
P304page(s)3472-3479
P577publication date2009-06-01
P1433published inJournal of Clinical OncologyQ400292
P1476titleDasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial
P478volume27

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