European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia

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European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia is …
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P6179Dimensions Publication ID1047140338
P356DOI10.1038/LEU.2016.104
P3181OpenCitations bibliographic resource ID2024912
P932PMC publication ID4991363
P698PubMed publication ID27121688

P50authorKimmo PorkkaQ51782104
Andreas HochhausQ37829812
Delphine ReaQ46399398
P2093author name stringR Hehlmann
D-W Kim
G Rosti
J L Steegmann
H J Khoury
J Mayer
M Breccia
R E Clark
M Baccarani
S Saussele
T D Kim
V García-Gutiérrez
L F Casado
D Milojkovic
P Le Coutre
P2860cites workImpaired fasting glucose level as metabolic side effect of nilotinib in non-diabetic chronic myeloid leukemia patients resistant to imatinibQ51474966
Imatinib treatment duration is related to decreased estimated glomerular filtration rate in chronic myeloid leukemia patientsQ51604310
Peripheral artery occlusive disease in chronic phase chronic myeloid leukemia patients treated with nilotinib or imatinibQ52884682
Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-α in newly diagnosed chronic myeloid leukemiaQ53156805
Retrospective multicenter study on the development of peripheral lymphocytosis following second‐line dasatinib therapy for chronic myeloid leukemiaQ53432205
Rapid onset of peripheral artery disease in a chronic myeloid leukemia patient without prior arterial disorder: direct relationship with nilotinib exposure and clinical outcomeQ54355007
Severe peripheral arterial disease during nilotinib therapyQ54419090
Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysisQ54446241
Rapid and sustained increase of large granular lymphocytes and rare cytomegalovirus reactivation during dasatinib treatment in chronic myelogenous leukemia patientsQ54499425
Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-upQ54504324
Nilotinib treatment-associated peripheral artery disease and sudden death: yet another reason to stick to imatinib as front-line therapy for chronic myelogenous leukemia.Q54586024
Hepatotoxicity of Tyrosine Kinase Inhibitors: Clinical and Regulatory PerspectivesQ38101884
Tyrosine Kinase Inhibitors: Their On-Target Toxicities as Potential Indicators of EfficacyQ38101885
Dasatinib, large granular lymphocytosis, and pleural effusion: useful or adverse effect?Q38161155
Management of adverse events associated with tyrosine kinase inhibitors in chronic myeloid leukemiaQ38392679
The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemiaQ39229989
Tuberculous and non-tuberculous granulomatous lymphadenitis in patients receiving imatinib mesylate (glivec) for metastatic gastrointestinal stromal tumorQ39636564
The BCR/ABL-inhibitors imatinib, nilotinib and dasatinib differentially affect NK cell reactivityQ39741862
Simultaneous manifestation of pleural effusion and acute renal failure associated with dasatinib: a case report.Q40229471
Hemorrhagic colitis caused by dasatinib following cytomegalovirus enterocolitis in a patient with chronic myelogenous leukemia in the second chronic phaseQ40322600
Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trialQ40807968
Vascular safety issues in CML patients treated with BCR/ABL1 kinase inhibitors.Q41668621
Successful rechallenge with imatinib in a patient with chronic myeloid leukemia who previously experienced imatinib mesylate induced pneumonitisQ41857102
Dasatinib inhibits proinflammatory functions of mature human neutrophilsQ41885572
Reactivation of chronic hepatitis B infection related to imatinib mesylate therapyQ41892625
Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up resultsQ41899882
Nilotinib Attenuates Renal Injury and Prolongs Survival in Chronic Kidney DiseaseQ42015762
Low incidence rate of opportunistic and viral infections during imatinib treatment in chronic myeloid leukemia patients in early and late chronic phaseQ42276725
Platelet dysfunction associated with ponatinib, a new pan BCR-ABL inhibitor with efficacy for chronic myeloid leukemia resistant to multiple tyrosine kinase inhibitor therapyQ42323680
Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trialQ42613611
Expanding Nilotinib Access in Clinical Trials (ENACT), an open-label multicenter study of oral nilotinib in adult patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase or blast crisis.Q42621930
Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemiaQ42867411
The clinical impact of ponatinib on the risk of bleeding in patients with chronic myeloid leukemiaQ42958720
Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemiaQ43043759
Relative hypocalcaemia and muscle cramps in patients receiving imatinib for gastrointestinal stromal tumour.Q43056046
Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusionQ43092618
Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumorsQ43182188
Peripheral neuropathy on imatinib treatment for chronic myeloid leukaemia: suspected adverse drug interaction with amlodipineQ43256707
Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemiaQ43262982
Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg dailyQ43278551
Imatinib mesylate-induced acute liver failure in a patient with gastrointestinal stromal tumorsQ43296843
Severe hepatitis and complete molecular response caused by imatinib mesylate: possible association of its serum concentration with clinical outcomesQ43628935
Effect of long term imatinib on bone in adults with chronic myelogenous leukemia and gastrointestinal stromal tumorsQ43671220
Multiple eruptive dermatofibromas related to imatinib treatmentQ43779022
Renal failure associated with a specific inhibitor of BCR-ABL tyrosine kinase, STI 571.Q43935639
Cerebral oedema as a possible complication of treatment with imatinibQ44017898
Imatinib mesylate and gray hairQ44094545
Incidence, risk factors and management of pleural effusions during dasatinib treatment in unselected elderly patients with chronic myelogenous leukaemiaQ44129015
Imatinib mesylate-induced hepato-toxicity in chronic myeloid leukemia demonstrated focal necrosis resembling acute viral hepatitisQ44161664
Hypersensitivity pneumonitis related to imatinib mesylateQ44178101
Managing cutaneous reactions to imatinib therapyQ44202316
Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation.Q44291160
Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general populationQ44306071
Adverse cutaneous reactions to imatinib (STI571) in Philadelphia chromosome-positive leukemias: a prospective study of 54 patientsQ44312442
A spectrum of skin reactions caused by the tyrosine kinase inhibitor imatinib mesylate (STI 571, Glivec).Q44339633
Development of Varicella-Zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate.Q44358941
Histological features of acute hepatitis after imatinib mesylate treatmentQ44443460
Gynaecomastia in men with chronic myeloid leukaemia after imatinibQ44474954
Prognostic factors for patients with chronic myeloid leukaemia in chronic phase treated with imatinib mesylate after failure of interferon alfaQ44529440
Acute renal failure secondary to imatinib mesylate treatment in chronic myeloid leukemiaQ44548386
Fatal hepatic necrosis following imatinib mesylate therapyQ44625224
Reactivation of porphyria cutanea tarda as a possible side effect of Imatinib at high dosage in chronic myeloid leukemiaQ44628909
Ponatinib in refractory Philadelphia chromosome-positive leukemiasQ27851967
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemiasQ28246193
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALLQ28246204
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemiaQ29547900
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemiaQ29614280
Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With ImatinibQ29999611
Phase III, randomized, open-label study of daily imatinib mesylate 400 mg versus 800 mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: tyrosine kinase inhibitor optimizatiQ30357011
Cardiovascular and pulmonary adverse events in patients treated with BCR-ABL inhibitors: Data from the FDA Adverse Event Reporting SystemQ30884142
Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV.Q30891587
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosomeQ33336718
The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phaseQ33358304
Thrombotic thrombocytopenic purpura in a patient treated with imatinib mesylate: true association or mere coincidence?Q33365677
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intoleranceQ33376325
Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib.Q33379225
Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemiaQ33379934
Tasigna for chronic and accelerated phase Philadelphia chromosome--positive chronic myelogenous leukemia resistant to or intolerant of imatinibQ33381007
Bleeding diathesis in patients with chronic myelogenous leukemia receiving dasatinib therapyQ33383664
Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemiaQ33384361
Peripheral neuropathy as an adverse effect of imatinib therapy.Q54616499
Nilotinib in a patient with postnecrotic liver cirrhosis related to imatinib.Q54641635
Real-life comparison of severe vascular events and other non-hematological complications in patients with chronic myeloid leukemia undergoing second-line nilotinib or dasatinib treatment.Q55068849
Pleural Effusion in Patients With Chronic Myelogenous Leukemia Treated With Dasatinib After Imatinib FailureQ57731587
Improved tolerability by a modified intermittent treatment schedule of dasatinib for patients with chronic myeloid leukemia resistant or intolerant to imatinibQ58023728
Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response oQ58023854
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapyQ58023949
Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phaseQ58023953
UGT1A1 promoter polymorphism increases risk of nilotinib-induced hyperbilirubinemiaQ58414397
Reversible hair depigmentation in a patient treated with imatinibQ58449048
The duration of the use of imatinib mesylate is only weakly related to elevated BNP levels in chronic myeloid leukaemia patientsQ58847619
Lung Abnormalities after Dasatinib Treatment for Chronic Myeloid LeukemiaQ59640192
Altered Bone and Mineral Metabolism in Patients Receiving Imatinib MesylateQ60021753
Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial.Q64911638
Imatinib mesylate induces hypophosphatemia in patients with chronic myeloid leukemia in late chronic phase, and this effect is associated with responseQ79372992
In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'Q79500683
Corticosteroids can reverse severe imatinib-induced hepatotoxicityQ79753992
A long-term time course of colorimetric assessment of the effects of imatinib mesylate on skin pigmentation: a study of five patientsQ79797463
Imatinib-induced optic neuritis in a patient of chronic myeloid leukemiaQ80101748
The Council of Europe recommendation Rec(2006)7 on management of patient safety and prevention of adverse events in health careQ81812387
A prospective evaluation of cardiac function in patients with chronic myeloid leukaemia treated with imatinibQ82209172
CML: how low can you go?Q82431116
Evaluation of tolerability and efficacy of imatinib mesylate in elderly patients with chronic phase CML: ELDERGLI studyQ83401553
Pharmacokinetics of nilotinib in imatinib-resistant/intolerant chronic myeloid leukemia patients on hemodialysis for chronic renal failureQ83622000
Nilotinib-associated vascular eventsQ84223022
Fully reversible pulmonary arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemiaQ84481026
Effect of the tyrosine kinase inhibitors (sunitinib, sorafenib, dasatinib, and imatinib) on blood glucose levels in diabetic and nondiabetic patients in general clinical practiceQ84664163
Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in chronic myeloid leukemia: a single institution studyQ86419511
Treatment with dasatinib for chronic myeloid leukemia following imatinib-induced hepatotoxicityQ86826642
Hypopigmented macules secondary to imatinib for the treatment of chronic myeloid leukemia: a histopathologic and immunohistochemical studyQ87171627
In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'Q94507897
In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'Q94507901
In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'Q94507905
Practical management of tyrosine kinase inhibitor-associated side effects in GIST.Q37767003
Activity and Safety of Dasatinib as Second-Line Treatment or in Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia PatientsQ37870181
Physician's guide to the clinical management of adverse events on nilotinib therapy for the treatment of CML.Q37917120
Adverse cutaneous reactions secondary to tyrosine kinase inhibitors including imatinib mesylate, nilotinib, and dasatinib.Q37930709
Characteristics of, and risk factors for, infections in patients with cancer treated with dasatinib and a brief review of other complicationsQ37977471
Rash with the multitargeted kinase inhibitors nilotinib and dasatinib: meta-analysis and clinical characterizationQ38067464
Occurrence and current management of side effects in chronic myeloid leukemia patients treated frontline with tyrosine kinase inhibitorsQ38087737
Imatinib, dasatinib and nilotinib: a review of adverse cutaneous reactions with emphasis on our clinical experience.Q38101103
Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trialQ33384766
The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo.Q33384822
Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemiaQ33387517
Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phaseQ33387519
Activity and tolerability of nilotinib: a retrospective multicenter analysis of chronic myeloid leukemia patients who are imatinib resistant or intolerantQ33390350
Imatinib plus peginterferon alfa-2a in chronic myeloid leukemiaQ33393383
Minimal cross-intolerance with nilotinib in patients with chronic myeloid leukemia in chronic or accelerated phase who are intolerant to imatinibQ33394812
Expanding Nilotinib Access in Clinical Trials (ENACT): an open-label, multicenter study of oral nilotinib in adult patients with imatinib-resistant or imatinib-intolerant Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phaseQ33396120
Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION).Q33398716
Off-target effects of BCR-ABL1 inhibitors and their potential long-term implications in patients with chronic myeloid leukemiaQ33401360
A randomized trial of dasatinib 100 mg versus imatinib 400 mg in newly diagnosed chronic-phase chronic myeloid leukemiaQ33402939
Rapid mobilization of cytotoxic lymphocytes induced by dasatinib therapy.Q33404602
A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemiasQ33411250
Impact of dose intensity of ponatinib on selected adverse events: Multivariate analyses from a pooled population of clinical trial patientsQ33434455
Older patients with chronic myeloid leukemia (≥65 years) profit more from higher imatinib doses than younger patients: a subanalysis of the randomized CML-Study IV.Q33729437
Early onset hypercholesterolemia induced by the 2nd-generation tyrosine kinase inhibitor nilotinib in patients with chronic phase-chronic myeloid leukemiaQ33828570
Periorbital edema secondary to imatinib mesylateQ33867897
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.Q33997854
Imatinib 800 mg daily induces deeper molecular responses than imatinib 400 mg daily: results of SWOG S0325, an intergroup randomized PHASE II trial in newly diagnosed chronic phase chronic myeloid leukaemiaQ34022596
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemiaQ34183674
Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinibQ34210528
Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusionQ34289635
Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trialQ34297594
Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION).Q34310190
Severe adverse cutaneous reactions to drugsQ34314152
Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA Guideline Recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice GuidelinesQ34331941
The ophthalmological complications of targeted agents in cancer therapy: what do we need to know as ophthalmologists?Q34412979
Recommended standards for reports dealing with lower extremity ischemia: Revised versionQ34440231
Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to boneQ34508348
Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate.Q34566073
Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNetQ34567629
Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemiaQ34620246
Congestive heart failure is a rare event in patients receiving imatinib therapyQ34621382
Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML.Q51373837
Imatinib mesylate-induced interstitial pneumonitisQ44684110
Periorbital oedema and epiphora as ocular side effects of imatinib mesylate (Gleevec).Q44739628
High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemiaQ44834786
Erythropoietin is effective in improving the anemia induced by imatinib mesylate therapy in patients with chronic myeloid leukemia in chronic phaseQ44908385
Imatinib mesylate causes hypopigmentation in the skinQ44908400
Risk of tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: a meta-analysis.Q44993914
Long-term response to imatinib is not affected by the initial dose in patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: final update from the Tyrosine Kinase Inhibitor Optimization and Selectivity (TOPS) stQ45024357
Granulocyte--colony-stimulating factor (Filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase myelogenous leukemiaQ45148328
Imatinib (Gleevec)-induced hepatotoxicity.Q45187499
Pleural-pericardic effusion as uncommon complication in CML patients treated with ImatinibQ45197239
Early and tardive skin adverse events in chronic myeloid leukaemia patients treated with imatinibQ45227567
How I treat leukemia during pregnancyQ45286228
Nilotinib post-liver transplantation for acute hepatic failure related to imatinib.Q45919743
Long-term pattern of pleural effusion from chronic myeloid leukemia patients in second-line dasatinib therapyQ45994559
Hypolipemiant besides antileukemic effect of imatinib mesylateQ46071343
Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapyQ46084072
Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemiaQ46090252
Tuberculosis complicating imatinib treatment for chronic myeloid leukaemiaQ46104724
Results of high-dose imatinib mesylate in intermediate Sokal risk chronic myeloid leukemia patients in early chronic phase: a phase 2 trial of the GIMEMA CML Working PartyQ46124555
Pulmonary arterial hypertension in patients treated by dasatinibQ46176185
Reversible dasatinib-induced pulmonary arterial hypertension and right ventricle failure in a previously allografted CML patientQ46185511
Reversible severe pulmonary hypertension secondary to dasatinib in a patient with chronic myeloid leukemiaQ46262660
Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemiaQ46332211
Optic disc edema as a possible complication of Imatinib mesylate (Gleevec).Q46387826
Reversible drug-induced interstitial pneumonitis following imatinib mesylate therapyQ46453887
An evaluation of the cardiotoxicity of imatinib mesylateQ46583056
Gynecomastia in a male after dasatinib treatment for chronic myeloid leukemiaQ46606987
Use of dasatinib in the patient with Philadelphia chromosome-positive acute lymphoblastic leukaemia with resistance to imatinib and renal failureQ46614977
Bullous sweet syndrome in a patient with t(9;22)(q34;q11)-positive chronic myeloid leukemia treated with the tyrosine kinase inhibitor nilotinib: interphase cytogenetic detection of BCR-ABL- positive lesional cellsQ46696380
Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesisQ46709661
Fasting glucose improvement under dasatinib treatment in an accelerated phase chronic myeloid leukemia patient unresponsive to imatinib and nilotinibQ46717583
Alterations in creatine kinase, phosphate and lipid values in patients with chronic myeloid leukemia during treatment with imatinibQ46775147
Partial fanconi syndrome induced by imatinib therapy: a novel cause of urinary phosphate lossQ46794206
Tumor lysis syndrome during treatment with AMN107 (Nilotinib) in a patient with chronic myelogenous leukemia accelerated phaseQ46797030
Acute renal failure secondary to imatinib mesylate treatment in prostate cancer.Q46803794
Conjunctival hemorrhagic events associated with imatinib mesylate.Q46810398
Imatinib and hyperlipidemiaQ46863520
Imatinib mesylate as a cause of acute liver failureQ46956777
Patient-reported outcomes in acute leukemia: a roadmap for future researchQ48080881
Which health-related quality of life aspects are important to patients with chronic myeloid leukemia receiving targeted therapies and to health care professionals? GIMEMA and EORTC Quality of Life GroupQ48449111
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constitutedQ48527068
Fatal progressive cerebral ischemia in CML under third-line treatment with ponatinibQ48906440
Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signalingQ49291505
Usefulness of the 2012 European CVD risk assessment model to identify patients at high risk of cardiovascular events during nilotinib therapy in chronic myeloid leukemiaQ50998286
The use of imatinib mesylate has no adverse effects on the heart function. Results of a pilot study in patients with chronic myeloid leukemiaQ51149470
A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjectsQ51371803
Choosing the right TKI for chronic myeloid leukemia: when the truth lies in "long-term" safety and efficacyQ51372022
Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study.Q34639998
Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukaemia: results from the 24-month follow-up of the BELA trialQ34763374
Safety of bosutinib versus imatinib in the phase 3 BELA trial in newly diagnosed chronic phase chronic myeloid leukemiaQ35008618
Practical management of patients with chronic myeloid leukemia receiving imatinibQ35095956
Imatinib treatment: specific issues related to safety, fertility, and pregnancyQ35143836
Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors.Q35198387
Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinibQ35265868
Phase 3 study of nilotinib vs imatinib in Chinese patients with newly diagnosed chronic myeloid leukemia in chronic phase: ENESTchinaQ35560018
Switching to second-generation tyrosine kinase inhibitor improves the response and outcome of frontline imatinib-treated patients with chronic myeloid leukemia with more than 10% of BCR-ABL/ABL ratio at 3 months.Q35928884
Plasma exposure of imatinib and its correlation with clinical response in the Tyrosine Kinase Inhibitor Optimization and Selectivity TrialQ35930616
Imatinib-induced fatal acute liver failureQ36178243
Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survivalQ36370847
Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the European ENEST1st study.Q36442499
Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activityQ36447926
High-Resolution Computed Tomography Findings for Patients With Drug-Induced Pulmonary Toxicity, With Special Reference to Hypersensitivity Pneumonitis-Like Patterns in Gemcitabine-Induced CasesQ36804533
Analysis of the potential effect of ponatinib on the QTc interval in patients with refractory hematological malignanciesQ36888547
Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of a phase 3 studyQ37025987
European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013.Q37026032
Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failureQ37027759
Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemiaQ37059387
Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylateQ37068545
Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNetQ37163550
High-dose imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: high rates of rapid cytogenetic and molecular responsesQ37163734
Dasatinib in imatinib-resistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study: efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice dailyQ37194640
Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update.Q37287453
A successful renal transplantation for renal failure after dasatinib-induced thrombotic thrombocytopenic purpura in a patient with imatinib-resistant chronic myelogenous leukaemia on nilotinibQ37362975
Dasatinib treatment for Philadelphia chromosome-positive leukemias: practical considerationsQ37385960
Ocular side effects associated with imatinib mesylate and perifosine for gastrointestinal stromal tumorQ37403026
Pancreatic enzyme elevation in chronic myeloid leukemia patients treated with nilotinib after imatinib failureQ37470939
Renal failure associated with tyrosine kinase inhibitors--case report and review of the literatureQ37565808
Cardiotoxicity induced by tyrosine kinase inhibitorsQ37593059
Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferationQ37635609
Dasatinib and chronic myeloid leukemia: two-year follow-up in eight clinical trialsQ37642276
Acute renal failure under dasatinib therapyQ37683786
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalQ24082749
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectchronic myeloid leukemiaQ729735
mechanism of actionQ3271540
leukemiaQ29496
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)1648-71
P577publication date2016-08-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inLeukemiaQ6534498
P1476titleEuropean LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia
P478volume30

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Q54979821Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: Recommendations for clinical practice from the French Chronic Myeloid Leukemia Study Group.
Q53822299Divergent and Stereospecific Routes to Five to Eight-Membered 1,3- and 1,4-Di-Aza-Heterocycles via Ring-Opening Cyclization of Activated Aziridines with Aryl Amines
Q47094576Drug Repurposing for the Treatment of Acute Myeloid Leukemia
Q64228175Early and sustained deep molecular response achieved with nilotinib in high Sokal risk chronic myeloid leukemia patients
Q50016898Efficacy and safety of nilotinib therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase.
Q64287954Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells
Q90010384European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia
Q54977220Evolving treatment strategies in CML - moving from early and deep molecular responses to TKI discontinuation and treatment-free remission: is there a need for longer-term trial outcomes?
Q54119186Excellent outcomes of 2G-TKI therapy after imatinib failure in chronic phase CML patients.
Q94521558Expert opinion-management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors
Q59796321Feasibility of treatment discontinuation in chronic myeloid leukemia in clinical practice: results from a nationwide series of 236 patients
Q94484014Frequently asked questions regarding SARS-CoV-2 in cancer patients-recommendations for clinicians caring for patients with malignant diseases
Q56967295Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: results from a phase III trial
Q30245010Identification, prevention and management of cardiovascular risk in chronic myeloid leukaemia patients candidate to ponatinib: an expert opinion
Q64074838Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV
Q91867290Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients
Q92715365Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line
Q53119368Impact of Imatinib on the Fertility of Male Patients with Chronic Myelogenous Leukaemia in the Chronic Phase
Q55339567In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers.
Q47113340Incidence of second primary malignancies and related mortality in patients with imatinib-treated chronic myeloid leukemia
Q33646189Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia.
Q52648378Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases
Q92735773Is There a Role for Dose Modification of TKI Therapy in CML?
Q42279564Late onset of unilateral optic disk edema secondary to treatment with imatinib mesylate.
Q96230782Low low-density lipoprotein (LDL), cholesterol and triglycerides plasma levels are associated with reduced risk of arterial occlusive events in chronic myeloid leukemia patients treated with ponatinib in the real-life. A Campus CML study
Q95852568Low-dose tyrosine kinase inhibitors before treatment discontinuation do not impair treatment-free remission in chronic myeloid leukemia patients: Results of a retrospective study
Q94076945MDR1和CYP3A5基因多态性对伊马替尼治疗慢性骨髓性白血病预后的影响
Q92206177Managing chronic myeloid leukemia for treatment-free remission: a proposal from the GIMEMA CML WP
Q39411920Mechanisms of Resistance to ABL Kinase Inhibition in Chronic Myeloid Leukemia and the Development of Next Generation ABL Kinase Inhibitors
Q57797259Molecular pathogenesis of leukemia and leukemic stem cells (LSCs)
Q64938069Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration.
Q33439536Nilotinib first-line therapy in patients with Philadelphia chromosome-negative/BCR-ABL-positive chronic myeloid leukemia in chronic phase: ENEST1st sub-analysis
Q64991775Novel Score-based Decision Approach in Chronic Myeloid Leukemia Patients After Acute Toxic Imatinib-induced Liver Injury.
Q92022525Observational study of chronic myeloid leukemia Italian patients who discontinued tyrosine kinase inhibitors in clinical practice
Q54981978Outcomes of switching to dasatinib after imatinib-related low-grade adverse events in patients with chronic myeloid leukemia in chronic phase: the DASPERSE study.
Q55362356Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy.
Q90456937Pattern of Use and Long-Term Safety of Tyrosine Kinase Inhibitors: A Decade of Real-World Management of Chronic Myeloid Leukemia
Q88913397Plasma concentrations of dasatinib have a clinical impact on the frequency of dasatinib dose reduction and interruption in chronic myeloid leukemia: an analysis of the DARIA 01 study
Q103002088Plasma imatinib levels and ABCB1 polymorphism influences early molecular response and failure-free survival in newly diagnosed chronic phase CML patients
Q47877989Pleural effusion and molecular response in dasatinib-treated chronic myeloid leukemia patients in a real-life Italian multicenter series
Q52641875Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial
Q49553324Practical Management of Toxicities Associated With Bosutinib in Patients With Philadelphia Chromosome-Positive Chronic Myeloid Leukemia
Q89710631Prospects for achieving treatment-free remission in chronic myeloid leukaemia
Q51368335Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms.
Q38557421Recovering from chronic myeloid leukemia: the patients' perspective seen through the lens of narrative medicine
Q90738566Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study
Q56961222Reply to Constance et al
Q42361988Research in the heart of hematology: chronic myeloid leukemia 2017.
Q55177555Residual Peripheral Blood CD26+ Leukemic Stem Cells in Chronic Myeloid Leukemia Patients During TKI Therapy and During Treatment-Free Remission.
Q38789049Second line small molecule therapy options for treating chronic myeloid leukemia
Q47727670Severe liver toxicity in a chronic myeloid leukemia patient probably induced by a drug interaction between imatinib and sertraline
Q37512201Short overview on the current treatment of chronic myeloid leukemia in chronic phase
Q52715772Similar expression profiles in CD34+ cells from chronic phase chronic myeloid leukemia patients with and without deep molecular responses to nilotinib
Q54065188The DESTINY of chronic myeloid leukeamia
Q38642952The Safety of Bosutinib for the Treatment of Chronic Myeloid Leukemia
Q90029088The argument for using imatinib in CML
Q89776915The incidence and natural history of dasatinib complications in the treatment of chronic myeloid leukemia
Q64078772The natural history of vascular and other complications in patients treated with nilotinib for chronic myeloid leukemia
Q47159332The use of the tyrosine kinase inhibitor Nilotinib in Spondyloarthritis: does targeting inflammatory pathways with a treatment lead to vascular toxicity?
Q50997822Treating the chronic-phase chronic myeloid leukemia patient: which TKI, when to switch and when to stop?
Q55005455Treatment-free remission in chronic myeloid leukemia: floating between expectation and evidence.
Q39423384Treatment-free remission in patients with chronic myeloid leukemia
Q95818691Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN)
Q56977895Tyrosine Kinase Inhibitor Interruptions, Discontinuations and Switching in Patients with Chronic-Phase Chronic Myeloid Leukemia in Routine Clinical Practice: SIMPLICITY
Q92110376Tyrosine Kinase Inhibitors Available for Chronic Myeloid Leukemia: Efficacy and Safety
Q52567954Tyrosine Kinase Inhibitors in the Treatment of Chronic-Phase CML: Strategies for Frontline Decision-making
Q92715817Tyrosine kinase inhibitor-induced carotid stenosis: A case report
Q30242015Tyrosine kinase inhibitors in chronic myeloid leukaemia: which, when, for whom?
Q39226064Tyrosine kinase inhibitors: potential use and safety considerations in HIV-1 infection.
Q90710117WHO 2016 Definition of Chronic Myeloid Leukemia and Tyrosine Kinase Inhibitors
Q49743400What is treatment free remission in chronic myeloid leukemia?
Q88150038[How I treat newly diagnosed chronic myeloid leukemia in chronic phase]

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