Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor

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Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MT.2009.279
P932PMC publication ID2839431
P698PubMed publication ID19953082
P5875ResearchGate publication ID40046083

P50authorAndrew P ByrnesQ55193693
P2093author name stringJie Tian
Jeffrey S Smith
Zhili Xu
P2860cites workPotent ulcerogenic actions of platelet-activating factor on the stomachQ59065369
Mechanism of Anaphylactic Death in the MouseQ59094648
Evidence of a role for paf-acether in the pathophysiology of the shock stateQ62083815
Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responsesQ64378490
Rodent nonclinical safety evaluation studies of SCH 58500, an adenoviral vector for the p53 geneQ64379227
Hypotensive action of IgG preparations containing aggregates is suppressed by PAF-receptor antagonist BN 52021 and by gadolinium chloride (an agent blocking Kupffer cell function)Q67929057
CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivoQ69148078
Obligatory role of nitric oxide in platelet-activating factor-induced microvascular leakageQ74341905
Splenectomy attenuates superoxide anion release into the hepatic sinusoids after lipopolysaccharide challengeQ78147843
Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vectorQ24555782
Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infectionQ27489378
Elimination of innate immune responses and liver inflammation by PEGylation of adenoviral vectors and methylprednisoloneQ33369785
Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy.Q33382953
Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF.Q33456249
Species specificity of the platelet responses to 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholineQ33484231
Acetyl glyceryl ether phosphorylcholine. Intravascular alterations following intravenous infusion into the baboonQ33486402
Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactionsQ33713324
Role of platelet-activating factor in cardiovascular pathophysiology.Q34051712
Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated ratsQ34572515
Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxisQ34586645
Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applicationsQ34717992
Lexipafant and acute pancreatitis: a critical appraisal of the clinical trialsQ35003210
Intravascular adenoviral agents in cancer patients: lessons from clinical trialsQ35043094
Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processesQ35621992
Influence of method of systemic administration of adenovirus on virus-mediated toxicity: focus on mortality, virus distribution, and drug metabolismQ36395442
Comparison of adenoviruses from species B, C, E, and F after intravenous deliveryQ38297861
Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement systemQ40012391
Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applicationsQ40701479
Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187.Q41780241
Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatmentQ41886673
Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouseQ41916597
Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentrationQ42075404
Study of the effector mechanism involved in the production of haemorrhagic necrosis of the small intestine in rat passive anaphylaxis.Q42279611
Pharmacology of ABT-491, a highly potent platelet-activating factor receptor antagonistQ42549572
Pathways of anaphylaxis in the mouseQ43952644
A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cellsQ44535618
A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells.Q44662326
Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates.Q44765402
Rapid Kupffer cell death after intravenous injection of adenovirus vectorsQ45119497
Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversionQ45158832
Unexpected pulmonary uptake of adenovirus vectors in animals with chronic liver diseaseQ45872936
Wild-type adenoviruses from groups A-F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependentQ45875332
Porcine toxicology studies of SCH 58500, an adenoviral vector for the p53 geneQ45882937
Simple method for quantitation of enhanced vascular permeability.Q46605899
Validation of volume-pressure recording tail-cuff blood pressure measurementsQ47304414
Severe pulmonary pathology after intravenous administration of vectors in cirrhotic ratsQ47353872
PAF increases vascular permeability in selected tissues: effect of BN-52021 and L-655,240.Q50893420
Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.Q52512619
Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism.Q54519052
Splenectomy alters Kupffer cell response to endotoxin.Q54752214
P433issue3
P921main subjectAdenoviridaeQ193447
P304page(s)609-616
P577publication date2009-12-01
P1433published inMolecular TherapyQ15762400
P1476titleInduction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor
P478volume18

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cites work (P2860)
Q38961417A novel pancreatropic coxsackievirus vector expressing glucagon-like peptide 1 reduces hyperglycemia in streptozotocin-treated mice
Q38187126Adenovirus-triggered innate signalling pathways
Q47300209And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation
Q50977875Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy.
Q55452882Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease.
Q34982825Helper-dependent adenoviral vectors for liver-directed gene therapy.
Q35126751IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells
Q35800342Intratumoral delivery of CD154 homolog (Ad-ISF35) induces tumor regression: analysis of vector biodistribution, persistence and gene expression
Q42285876Preclinical safety evaluation of rAd5-hTERTC27 by intravenous injection

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