HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus

scientific article

HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2009PLoSO...4.4662B
P356DOI10.1371/JOURNAL.PONE.0004662
P932PMC publication ID2646130
P698PubMed publication ID19252740
P5875ResearchGate publication ID24147269

P50authorJürgen BorlakQ89428779
P2093author name stringMonika Niehof
P2860cites workHepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cellsQ46868194
Pancreatic islet transplantation in cynomolgus monkeys. Initial studies and evidence that cyclosporine impairs glucose tolerance in normal monkeys.Q51618411
Insulin, Glucagon, and Somatostatin Receptors on Cultured Cells and Clones from Rat Islet Cell TumorQ67255957
Interference by cyclosporine with the endocrine function of the canine pancreasQ68166601
Effect of cyclosporin A on carbohydrate metabolism in the ratQ69691950
Cyclosporin A and islet functionQ70212878
Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretionQ74248211
Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alphaQ78057398
The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolismQ24654815
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequencesQ28207712
The role of HNF4A variants in the risk of type 2 diabetesQ28241967
NFAT proteins: key regulators of T-cell development and functionQ28253919
HNF4A genetic variants: role in diabetesQ28305898
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouseQ28512187
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretionQ28513687
Mechanisms linking obesity to insulin resistance and type 2 diabetesQ29614887
Transcriptional regulation by calcium, calcineurin, and NFATQ29620410
Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.Q33890050
Mechanisms of action of cyclosporine.Q33908049
A transcription factor regulatory circuit in differentiated pancreatic cellsQ33951968
Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunctionQ34486684
Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expressionQ34547407
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and functionQ34567627
Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell functionQ34796638
Role of transcription factor NFAT in glucose and insulin homeostasisQ35131709
Regulation of Pancreatic .BETA.-cell Function by the HNF Transcription Network: Lessons from Maturity-Onset Diabetes of the Young (MODY)Q35582328
New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and meta-analysisQ35691924
Experience with cyclosporine in heart transplantationQ35711274
Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alphaQ35720840
Immunosuppression and cancer: the ciclosporin caseQ36170919
RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brainQ38332779
HNF4 alpha and the Ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathyQ40026848
Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.Q40449521
Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cellsQ40777683
Drug-induced disorders of glucose toleranceQ40880777
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoformsQ41729392
Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cellsQ42510305
Prospective, multicenter, randomized trial to compare incidence of new-onset diabetes mellitus and glucose metabolism in patients receiving cyclosporine microemulsion versus tacrolimus after de novo kidney transplantationQ42654357
Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma CellsQ42798453
Determination of insulin in a single islet of Langerhans by high-performance liquid chromatography with fluorescence detectionQ44011349
Incidence and Cost of New Onset Diabetes Mellitus Among U.S. Wait-Listed and Transplanted Renal Allograft RecipientsQ44444372
Vasopeptidase inhibition prevents nephropathy in Zucker diabetic fatty rats.Q44653138
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcyclosporineQ367700
P304page(s)e4662
P577publication date2009-03-02
P1433published inPLOS OneQ564954
P1476titleHNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus
P478volume4

Reverse relations

cites work (P2860)
Q39721171A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion
Q54345360Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine.
Q33813163HNF4alpha dysfunction as a molecular rational for cyclosporine induced hypertension
Q38511537New-onset diabetes mellitus after pediatric liver transplantation
Q37877294The importance of different immunosuppressive regimens in the development of posttransplant diabetes mellitus
Q34140521Transforming growth factor-β1 suppresses hepatitis B virus replication by the reduction of hepatocyte nuclear factor-4α expression
Q89187668Treatment of cyclosporine induced hypertension: Results from a long-term observational study using different antihypertensive medications

Search more.