A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion

scientific article published on 30 March 2010

A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1053448872
P356DOI10.1038/TPJ.2010.22
P698PubMed publication ID20351753

P2093author name stringC H Kim
Y S Kim
I Kim
H C Lee
C W Ahn
S-H Jeong
B S Cha
E S Kang
J H Rim
S J Ko
Y S Yim
P2860cites workCloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cellsQ24292494
Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granulesQ24301974
In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretionQ24303979
The International HapMap ProjectQ27860695
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variantsQ28249275
A genome-wide association study identifies novel risk loci for type 2 diabetesQ28287727
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretionQ28506358
Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretionQ28564600
Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosisQ28576907
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsQ29547214
Post-transplant diabetes mellitus: increasing incidence in renal allograft recipients transplanted in recent yearsQ31904809
HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitusQ33413749
Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivoQ33947920
Pharmacological agents that directly modulate insulin secretionQ33964696
Posttransplant diabetes mellitus in kidney allograft recipients: incidence, risk factors, and managementQ34555444
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and functionQ34567627
Calcineurin/NFAT signaling in the beta-cell: From diabetes to new therapeuticsQ34689362
New-onset diabetes after kidney transplantation: risk factors.Q36665946
New-onset posttransplantation diabetes mellitus: insulin resistance or insulinopenia? Impact of immunosuppressive drugs, cytomegalovirus and hepatitis C virus infectionQ37065465
Genome-wide association study for type 2 diabetes: clinical applicationsQ37412138
Down syndrome candidate region 1 increases the stability of the IkappaBalpha protein: implications for its anti-inflammatory effectsQ40216264
Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma CellsQ42798453
Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolismQ43265419
beta-Cell dysfunction rather than insulin resistance is the main contributing factor for the development of postrenal transplantation diabetes mellitusQ43629277
New-onset diabetes after kidney transplantation: an application of 2003 International GuidelinesQ43977077
Diabetes mellitus after kidney transplantation in the United StatesQ44326129
Posttransplant diabetes mellitus and atherosclerotic events in renal transplant recipients: a prospective studyQ45281305
New-onset diabetes mellitus after kidney transplantation: the role of immunosuppressionQ46449548
mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetesQ46823840
The impact of early-diagnosed new-onset post-transplantation diabetes mellitus on survival and major cardiac eventsQ46881097
Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients.Q51476761
A Polymorphism in the Zinc Transporter Gene SLC30A8 Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft RecipientsQ57500079
P433issue3
P304page(s)191-198
P577publication date2010-03-30
P1433published inThe Pharmacogenomics JournalQ10534704
P1476titleA low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion
P478volume11

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cites work (P2860)
Q36022057A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes
Q35715829Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis
Q38245901Dorothy Hodgkin Lecture 2014. Understanding genes identified by genome-wide association studies for type 2 diabetes
Q35861895Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish
Q33671124Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel
Q33726555Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion
Q39224992Identification of novel HLA-A 0201-restricted cytotoxic T lymphocyte epitopes from Zinc Transporter 8.
Q48169638Implications of impaired zinc homeostasis in diabetic cardiomyopathy and nephropathy.
Q51310702Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes.
Q37198275Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance
Q37073892Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia
Q42209549Post-renal transplant diabetes mellitus in korean subjects: superimposition of transplant-related immunosuppressant factors on genetic and type 2 diabetic risk factors
Q38257329SLC30A8 mutations in type 2 diabetes
Q36065083The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion
Q28390590Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation
Q26829276Zinc transporter 8 (ZnT8) and β cell function

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