Identification of SOX9 interaction sites in the genome of chondrocytes

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Identification of SOX9 interaction sites in the genome of chondrocytes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...510113O
P356DOI10.1371/JOURNAL.PONE.0010113
P932PMC publication ID2852419
P698PubMed publication ID20404928
P5875ResearchGate publication ID43202215

P50authorBenoit de CrombruggheQ114389868
Hideyo YasudaQ114390207
P2093author name stringChun-do Oh
Sankar N Maity
Shoudan Liang
Jiexin Zhang
Francoise Coustry
Jing-Fang Lu
P2860cites workPhosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancerQ22254066
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formationQ24292169
MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblastsQ24297101
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationQ24600279
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal developmentQ24616861
A genomic code for nucleosome positioningQ24650238
Genome-wide location and function of DNA binding proteinsQ28131765
An allele of COL9A2 associated with intervertebral disc diseaseQ28140014
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related geneQ28242642
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeletonQ28508641
Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formationQ28510414
The Sox9 transcription factor determines glial fate choice in the developing spinal cordQ28512816
Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartmentQ28513589
The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bonesQ28566665
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivoQ28572747
Chondroadherin expression changes in skeletal developmentQ28581111
SOX9 is required for the differentiation of paneth cells in the intestinal epitheliumQ28586813
The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamilyQ28586944
Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbsQ28589952
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralizationQ28590890
Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3Q28591707
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6Q28593218
Functional analysis of Sox8 and Sox9 during sex determination in the mouseQ28594554
Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancerQ33331554
The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner.Q51422240
Conditional inactivation of Sox9: a mouse model for campomelic dysplasia.Q52123522
Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation.Q52177158
Syndecan-3 is a selective regulator of chondrocyte proliferation.Q54404983
Activation of beta-catenin-LEF/TCF signal pathway in chondrocytes stimulates ectopic endochondral ossification.Q54797832
Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene ExpressionQ57129723
Differential expression of small chondroitin/dermatan sulfate proteoglycans, PG-I/biglycan and PG-II/decorin, by vascular smooth muscle and endothelial cells in cultureQ67765268
Expression of IL-1 genes in human and bovine chondrocytes: a mechanism for autocrine control of cartilage matrix degradationQ70164706
In situ localization of PTH/PTHrP receptor mRNA in the bone of fetal and young ratsQ70472927
A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic miceQ71290589
Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic miceQ72424312
Dimerization of SOX9 is required for chondrogenesis, but not for sex determinationQ73599679
Distribution of the collagen-binding integrin alpha10beta1 during mouse developmentQ77083002
Nucleosome positions predicted through comparative genomicsQ80238247
Cytokines and their role in the pathophysiology of osteoarthritisQ33753628
VEGF and vascular fusion: implications for normal and pathological vesselsQ33764024
Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9Q33850158
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursorsQ34055618
Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formationQ34249713
Regulation of bone development and maintenance by Runx2.Q34584595
A high-resolution atlas of nucleosome occupancy in yeastQ34688532
The DNA-encoded nucleosome organization of a eukaryotic genomeQ34907179
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathwayQ35006524
Expression profiling of metalloproteinases and their inhibitors in synovium and cartilageQ35605620
Histones and histone modificationsQ35842800
Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivoQ36177520
Usurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans?Q36430826
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen geneQ36567842
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.Q36676468
Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactionsQ36816992
Mechanisms that specify promoter nucleosome location and identityQ37180651
Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitmentQ37426667
Increased expression of CD44 in bovine articular chondrocytes by catabolic cellular mediatorsQ38289120
An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytesQ38354829
Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcomaQ40185670
Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenaseQ40614792
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reactionQ40738183
A novel chordin-like protein inhibitor for bone morphogenetic proteins expressed preferentially in mesenchymal cell lineagesQ40799972
SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.Q40831754
Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alphaQ40903189
Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen geneQ41270274
Cathepsin B as a marker of the dedifferentiated chondrocyte phenotypeQ41341332
Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD.Q41985465
Involvement of the sonic hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin raysQ42461732
Trans-activation of the mouse cartilage-derived retinoic acid-sensitive protein gene by Sox9.Q42815953
Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasiasQ42831879
Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormoneQ43510798
Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancerQ48010578
Characterization of epiphycan, a small proteoglycan with a leucine-rich repeat core proteinQ48047094
Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-cateninQ48151618
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)e10113
P577publication date2010-04-09
P1433published inPLOS OneQ564954
P1476titleIdentification of SOX9 interaction sites in the genome of chondrocytes
P478volume5

Reverse relations

cites work (P2860)
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Q39270031A newly identified enhancer element responsible for type II collagen gene expression
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Q37708366Disruption of SATB2 or its long-range cis-regulation by SOX9 causes a syndromic form of Pierre Robin sequence
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Q37368635E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein
Q35879018Early induction of a prechondrogenic population allows efficient generation of stable chondrocytes from human induced pluripotent stem cells
Q35737205Ectopic expression of SOX9 in osteoblasts alters bone mechanical properties.
Q35548582Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish
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Q89715671Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity
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Q36285907Hyaline cartilage tissue is formed through the co-culture of passaged human chondrocytes and primary bovine chondrocytes
Q34996402In vivo genome-wide analysis of multiple tissues identifies gene regulatory networks, novel functions and downstream regulatory genes for Bapx1 and its co-regulation with Sox9 in the mammalian vertebral column
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Q52592784SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity.
Q37111035SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc.
Q37051549SOX9 directly regulates IGFBP-4 in the intestinal epithelium
Q38780862SOX9 drives WNT pathway activation in prostate cancer
Q34071414SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.
Q27341897SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties
Q53229089SOX9 regulates ERBB signalling in pancreatic cancer development.
Q34207443SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters
Q37608199SOX9: a stem cell transcriptional regulator of secreted niche signaling factors
Q35651336SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains
Q41520562Salvianolic acid B regulates gene expression and promotes cell viability in chondrocytes
Q42544735Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction
Q37177764Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development
Q28585673Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
Q36818228TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells
Q36412996The postnatal role of Sox9 in cartilage
Q34483803The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis

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