| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2004PNAS..10118105K |
| P356 | DOI | 10.1073/PNAS.0406927102 |
| P8608 | Fatcat ID | release_erschpwdqncczj6kfxiay7lgyy |
| P932 | PMC publication ID | 539790 |
| P698 | PubMed publication ID | 15601771 |
| P5875 | ResearchGate publication ID | 8127739 |
| P50 | author | Ivan Topisirovic | Q42738489 |
| Alex Kentsis | Q54485524 | ||
| P2093 | author name string | Katherine L B Borden | |
| Ling Shao | |||
| Biljana Culjkovic | |||
| P2860 | cites work | PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. | Q24291551 |
| The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth | Q24293421 | ||
| Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING | Q24298636 | ||
| Structural basis of m7GpppG binding to the nuclear cap-binding protein complex | Q24318674 | ||
| Control of biochemical reactions through supramolecular RING domain self-assembly | Q24539123 | ||
| RNA virus error catastrophe: direct molecular test by using ribavirin | Q24599371 | ||
| Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design | Q27617777 | ||
| Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins | Q27639133 | ||
| Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP | Q27739838 | ||
| eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation | Q27860920 | ||
| Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide | Q28240029 | ||
| Prediction of central nervous system embryonal tumour outcome based on gene expression | Q29618619 | ||
| Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap | Q29620550 | ||
| eIF4E expression in tumors: its possible role in progression of malignancies | Q33601639 | ||
| Internal ribosome entry site-mediated translation in hepatitis C virus replication. | Q33791608 | ||
| The lymphocytic choriomeningitis virus RING protein Z associates with eukaryotic initiation factor 4E and selectively represses translation in a RING-dependent manner | Q33801521 | ||
| Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis | Q33900139 | ||
| Coupled transcription and translation within nuclei of mammalian cells. | Q33952853 | ||
| Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis | Q33992131 | ||
| Ribavirin's antiviral mechanism of action: lethal mutagenesis? | Q34119894 | ||
| Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy | Q34306865 | ||
| Mechanisms of action of ribavirin in antiviral therapies | Q34521747 | ||
| The emerging roles of translation factor eIF4E in the nucleus | Q34522530 | ||
| Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis | Q34987550 | ||
| Pleiotropic mechanisms of ribavirin antiviral activities | Q35012758 | ||
| Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs | Q35125475 | ||
| The mRNA cap-binding protein eIF4E in post-transcriptional gene expression | Q35784506 | ||
| erbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification | Q36080272 | ||
| Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. | Q37729445 | ||
| Poliovirus translation: a paradigm for a novel initiation mechanism | Q38308386 | ||
| pH-dependent and ligand induced conformational changes of eucaryotic protein synthesis initiation factor eIF-(iso)4F: a circular dichroism study | Q38352182 | ||
| Gamma interferon and cadmium treatments modulate eukaryotic initiation factor 4E-dependent mRNA transport of cyclin D1 in a PML-dependent manner | Q39675370 | ||
| Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line. | Q40874096 | ||
| Translation of ODC mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation factor 4E. | Q41079245 | ||
| The effects of ribavirin on the GTP level and the VIP receptor dynamic of human IGR39 cells | Q41250251 | ||
| Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas | Q41822752 | ||
| Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis | Q42816270 | ||
| Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles | Q42918776 | ||
| Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin | Q43518067 | ||
| The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen | Q43545743 | ||
| The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. | Q43749953 | ||
| The metabolism of ribavirin in erythrocytes and nucleated cells | Q46071227 | ||
| Ribavirin monotherapy in patients with chronic hepatitis C: a retrospective study of 95 patients. | Q50588155 | ||
| Tritiated thymidine incorporation does not measure DNA synthesis in ribavirin-treated human cells. | Q50592454 | ||
| mRNA cap-1 methyltransferase in the SARS genome. | Q51667428 | ||
| Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas | Q59263692 | ||
| The proto-oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas | Q59263746 | ||
| Sustained loss of a neoplastic phenotype by brief inactivation of MYC | Q74413944 | ||
| Internal and overall motions of the translation factor eIF4E: cap binding and insertion in a CHAPS detergent micelle | Q77210983 | ||
| Competitive PCR to detect eIF4E gene amplification in head and neck cancer | Q77799167 | ||
| P433 | issue | 52 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ribavirin | Q421862 |
| P304 | page(s) | 18105-18110 | |
| P577 | publication date | 2004-12-15 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap | |
| P478 | volume | 101 |
| Q42424512 | A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. |
| Q43087319 | A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E. |
| Q33739303 | Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer |
| Q38098701 | Aiding and abetting cancer: mRNA export and the nuclear pore |
| Q37218012 | Amplified in Breast Cancer Regulates Transcription and Translation in Breast Cancer Cells |
| Q38626082 | Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry |
| Q39869989 | Anti-tumor effect of ribavirin in combination with interferon-α on renal cell carcinoma cell lines in vitro |
| Q99551805 | Antitumor effects of ribavirin in combination with TMZ and IFN-β in malignant glioma cells |
| Q38732613 | Autophagy suppression sensitizes glioma cells to IMP dehydrogenase inhibition-induced apoptotic death. |
| Q38001940 | Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target |
| Q34624747 | Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states. |
| Q36596874 | Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas |
| Q40872139 | Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate |
| Q33558533 | Crimean-Congo hemorrhagic fever virus-encoded ovarian tumor protease activity is dispensable for virus RNA polymerase function |
| Q35575887 | Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry |
| Q38943265 | Efficacy of ribavirin against malignant glioma cell lines. |
| Q47282300 | Efficacy of ribavirin against malignant glioma cell lines: Follow-up study |
| Q34240544 | Eukaryotic initiation factor 4F: a vulnerability of tumor cells |
| Q38227377 | Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond |
| Q91879057 | Evaluation of the potential of a new ribavirin analog impairing the dissemination of ovarian cancer cells |
| Q37660329 | First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines |
| Q34105627 | Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity. |
| Q36298008 | Further evidence that ribavirin interacts with eIF4E |
| Q40311468 | GC-selective DNA-binding antibiotic, mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis. |
| Q42153541 | Gene expression-based risk score in diffuse large B-cell lymphoma |
| Q38195115 | Hair curvature: a natural dialectic and review |
| Q38874189 | Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A. |
| Q111442246 | Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E |
| Q39163778 | Identification of drug candidate against prostate cancer from the aspect of somatic cell reprogramming |
| Q36904927 | Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E. |
| Q27674708 | Improved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects |
| Q42701473 | Inducible drug modification: a new form of resistance |
| Q37636705 | Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells |
| Q36814636 | Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors |
| Q47584869 | Inhibition of eIF4E cooperates with chemotherapy and immunotherapy in renal cell carcinoma. |
| Q50556822 | Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens. |
| Q36959906 | Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance |
| Q39676973 | Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells |
| Q38543715 | Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line |
| Q35142765 | MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responses |
| Q36312805 | Mechanisms of action of ribavirin against distinct viruses |
| Q37117628 | Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo |
| Q24317552 | Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP |
| Q36644831 | Mutation in the Hepatitis E Virus Polymerase and Outcome of Ribavirin Therapy |
| Q35979113 | New sources of drugs for hematologic malignancies |
| Q37902875 | Oncogenic AKTivation of translation as a therapeutic target |
| Q37688853 | PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells. |
| Q41942808 | Pharmacological targeting of eIF4E in primary CLL lymphocytes |
| Q47722276 | Phase I study of induction chemotherapy with afatinib, ribavirin, and weekly carboplatin and paclitaxel for stage IVA/IVB human papillomavirus-associated oropharyngeal squamous cell cancer. |
| Q28755220 | Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon? |
| Q38116576 | Potential therapeutic applications of RNA cap analogs. |
| Q34572279 | Predicting interactome network perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia |
| Q35216351 | RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer |
| Q38980534 | RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth |
| Q38852157 | Regulation of Stem Cell Self-Renewal and Oncogenesis by RNA-Binding Proteins. |
| Q35642076 | Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila |
| Q91646021 | Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential |
| Q89761769 | Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit? |
| Q35758763 | Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia |
| Q52682258 | Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors. |
| Q24594939 | Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? |
| Q47720139 | Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. |
| Q24276089 | Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action |
| Q42033076 | Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap. |
| Q39950178 | Ribavirin targets eIF4E dependent Akt survival signaling |
| Q34917506 | Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer |
| Q37865381 | Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. |
| Q36882224 | S6K1 plays a key role in glial transformation |
| Q36870110 | SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis |
| Q37733841 | Silencing of translation initiation factor eIF3b promotes apoptosis in osteosarcoma cells |
| Q36020938 | Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue |
| Q27676269 | Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E |
| Q50573740 | Structural effects on the phosphorylation of 3-substituted 1-beta-D-ribofuranosyl-1,2,4-triazoles by human adenosine kinase. |
| Q42276001 | Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery |
| Q41135356 | TRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: relevance in human colorectal tumors |
| Q93382193 | Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia |
| Q34130816 | Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer |
| Q50046142 | Targeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia |
| Q39172901 | Targeting of protein translation as a new treatment paradigm for prostate cancer |
| Q26829652 | Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies |
| Q34988282 | Targeting the eIF4F translation initiation complex: a critical nexus for cancer development |
| Q38368049 | Targeting the translation machinery in cancer |
| Q34173253 | Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway |
| Q33747291 | Targeting the translational machinery as a novel treatment strategy for hematologic malignancies |
| Q37850227 | Targeting translation dependence in cancer |
| Q27027284 | Targeting translation initiation in breast cancer |
| Q38699320 | Targeting translation: eIF4E as an emerging anticancer drug target |
| Q38191794 | Targeting tumour-supportive cellular machineries in anticancer drug development |
| Q41036251 | The ABC7 regimen: a new approach to metastatic breast cancer using seven common drugs to inhibit epithelial-to-mesenchymal transition and augment capecitabine efficacy |
| Q43089875 | The Development of Novel Therapies for the Treatment of Acute Myeloid Leukemia (AML). |
| Q38634592 | The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer |
| Q53244096 | The HOX gene network in hepatocellular carcinoma. |
| Q59130174 | The Impact of Post-transcriptional Control: Better Living Through RNA Regulons |
| Q58580106 | The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo |
| Q34366602 | The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro |
| Q37848652 | The biological and therapeutic relevance of mRNA translation in cancer |
| Q36527188 | The eIF4E RNA regulon promotes the Akt signaling pathway |
| Q38710456 | The effects of antiviral treatment on breast cancer cell line |
| Q47151662 | The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity |
| Q38289051 | The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled |
| Q40616450 | The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia |
| Q39549442 | The eukaryotic translation initiation factor eIF4E wears a "cap" for many occasions |
| Q39295500 | The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation |
| Q36842143 | The oncogene eIF4E: using biochemical insights to target cancer |
| Q33781829 | The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus. |
| Q38990833 | The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation |
| Q35546455 | The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206 |
| Q40974570 | Therapeutic implication of concomitant chromosomal aberrations in patients with aggressive B-cell lymphomas |
| Q37837732 | Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. |
| Q35832407 | Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma |
| Q39383867 | Translation initiation factor eIF4E is a target for tumor cell radiosensitization. |
| Q37801949 | Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments |
| Q24338136 | Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1 |
| Q42946802 | Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer |
| Q40429761 | Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic. |
| Q38060894 | Using antimicrobial adjuvant therapy in cancer treatment: a review |
| Q84617612 | Want fries with that? Antimyeloma drug combos |
| Q34715457 | When will resistance be futile? |
| Q38922745 | eIF4E is an adverse prognostic marker of melanoma patient survival by increasing melanoma cell invasion |
| Q36920075 | eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling |
| Q28245804 | eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR |
| Q59136306 | eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity |
| Q37907202 | mRNA export and cancer |
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