Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

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Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1996PNAS...93..845V
P356DOI10.1073/PNAS.93.2.845
P932PMC publication ID40145
P698PubMed publication ID8570646
P5875ResearchGate publication ID14629173

P50authorDavid M. OrnitzQ37386214
Andrew B HerrQ50282143
P2093author name stringR Sasisekharan
G Waksman
R Langer
G Venkataraman
C L Cooney
V Sasisekharan
P2860cites workN.m.r. and molecular-modelling studies of the solution conformation of heparinQ24528140
Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 betaQ24563285
Three-dimensional structure of human basic fibroblast growth factorQ24563295
Crystal structure of basic fibroblast growth factor at 1.6 A resolutionQ27647318
New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factorQ27656280
Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factorQ27729397
Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycansQ28213234
Three-Dimensional Structures of Acidic and Basic Fibroblast Growth FactorsQ28267322
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiationQ28296150
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptorQ29616189
Refinement of the structure of human basic fibroblast growth factor at 1.6 Å resolution and analysis of presumed heparin binding sites by selenate substitutionQ30194894
Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesisQ30419847
Receptor- and heparin-binding domains of basic fibroblast growth factorQ33564620
Structure and mechanism of copper, zinc superoxide dismutaseQ34255150
Heparinase inhibits neovascularizationQ35056165
The FGF family of growth factors and oncogenesQ35335377
Complexity of FGF receptors: genetic basis for structural diversity and functional specificityQ35595596
A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membraneQ35818217
A dual receptor system is required for basic fibroblast growth factor activityQ36428185
Extracellular matrix-resident basic fibroblast growth factor: Implication for the control of angiogenesisQ36657969
The heparin-binding (fibroblast) growth factor family of proteinsQ38286731
FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides.Q38296447
Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factorQ38314305
Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4Q38314349
Preparation of affinity-fractionated, heparin-derived oligosaccharides and their effects on selected biological activities mediated by basic fibroblast growth factor.Q38321029
Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cellsQ38331586
Dimerization of cell surface receptors in signal transductionQ40579106
Structural and functional basis for hormone binding and receptor oligomerizationQ40668266
The ins and outs of fibroblast growth factorsQ40694270
The coordinated regulation of heparan sulfate, syndecans and cell behaviorQ40780342
Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.Q41487982
Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesisQ42476789
Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperactivityQ42816414
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferationQ54246457
Surface, subunit interfaces and interior of oligomeric proteinsQ68014868
Multivalent Ligand-Receptor Binding Interactions in the Fibroblast Growth Factor System Produce a Cooperative Growth Factor and Heparin Mechanism for Receptor DimerizationQ71642294
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectheparinQ190016
P304page(s)845-850
P577publication date1996-01-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePreferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation
P478volume93

Reverse relations

cites work (P2860)
Q52209541A dimeric ternary complex of FGFR [correction of FGFR1], heparin and FGF-1 leads to an 'electrostatic sandwich' model for heparin binding.
Q28582546A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth
Q42834409Basic fibroblast growth factor-binding peptide as a novel targeting ligand of drug carrier to tumor cells
Q38294596Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes
Q38331346Diversity does make a difference: fibroblast growth factor-heparin interactions
Q30650531Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans
Q34989550Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila
Q39111023Heparin modulates the mitogenic activity of fibroblast growth factor by inducing dimerization of its receptor. a 3D view by using NMR.
Q34166436Identification of a novel domain of fibroblast growth factor 2 controlling its angiogenic properties
Q35044639Inhibition by acharan sulphate of angiogenesis in experimental inflammation models
Q28587262Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development
Q52129710Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the "cooperative end structures" model.
Q37365612Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound
Q36448331Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex
Q38335430Molecular modeling studies on binding of bFGF to heparin and its receptor FGFR1.
Q40957417Monomer complexes of basic fibroblast growth factor and heparan sulfate oligosaccharides are the minimal functional unit for cell activation
Q61707991Morphological study of bone regeneration in the presence of 6-oxychitin
Q88212795Multivalent conjugates of basic fibroblast growth factor enhance in vitro proliferation and migration of endothelial cells
Q40206704Nature of Interaction between basic fibroblast growth factor and the antiangiogenic drug 7,7-(carbonyl-bis[imino-N-methyl-4,2-pyrrolecarbonylimino[N-methyl-4,2-pyrrole]-carbonylimino])-bis-(1,3-naphtalene disulfonate). II. Removal of polar interacti
Q41657939New strategies for chemokine inhibition and modulation: you take the high road and I'll take the low road
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Q28273441Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2
Q73850106Preparation of completely 6-O-desulfated heparin and its ability to enhance activity of basic fibroblast growth factor
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Q33780827Putting two and two together: crystal structure of the FGF-receptor complex
Q28294538Roles of platelet factor 4 in hematopoiesis and angiogenesis
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