Interleukin-6 increases the expression and activity of insulin-degrading enzyme.

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Interleukin-6 increases the expression and activity of insulin-degrading enzyme. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1085007505
P356DOI10.1038/SREP46750
P932PMC publication ID5399448
P698PubMed publication ID28429777

P50authorClaudia Regina CavaglieriQ58370636
Mara Patricia Traina Chacon-MikahilQ58370640
Mirian A KurautiQ64495850
P2093author name stringAntonio C Boschero
Gustavo J Santos
Luiz F Rezende
Everardo M Carneiro
Sandra M Ferreira
Guilherme D Telles
Carlos H G Sponton
José M Costa-Júnior
P2860cites workComplementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulinQ24299103
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayQ24531184
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoQ24683214
Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of InsulinQ27661904
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormonesQ27683870
Insulin degradation: progress and potentialQ28287093
Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese miceQ28537971
STATs and gene regulationQ29547796
From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation.Q30361595
Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart StudyQ30937160
Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin toleranceQ33939720
Muscles, exercise and obesity: skeletal muscle as a secretory organQ34265667
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.Q34857481
Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitusQ35078223
Improving patients' adherence to physical activity in diabetes mellitus: a reviewQ35770020
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in miceQ36087916
Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss MiceQ36088453
IL-6: from its discovery to clinical applicationsQ37735571
Targeting gp130 to prevent inflammation and promote insulin action.Q38134113
Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?Q38869928
Interleukin-6 enhances glucose-stimulated insulin secretion from pancreatic beta-cells: potential involvement of the PLC-IP3-dependent pathwayQ39602224
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseQ40227253
Interleukin-6 induces cellular insulin resistance in hepatocytesQ40687381
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK ratsQ40859035
Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer's Disease.Q41087317
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscleQ42135596
Insulin metabolism in human adipocytes from subcutaneous and visceral depotsQ42841779
IL-6 selectively stimulates fat metabolism in human skeletal muscleQ42914691
Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilizationQ43064604
Interleukin-6-deficient mice develop mature-onset obesityQ43851625
In VitroInhibition of Insulin-Degrading Enzyme by Long-Chain Fatty Acids and Their Coenzyme A ThioestersQ44440518
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exerciseQ44953597
Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contractionQ44953893
Weight-dependent differential contribution of insulin secretion and clearance to hyperinsulinemia of obesityQ46233134
Ciliary neurotrophic factor promotes survival of neonatal rat islets via the BCL-2 anti-apoptotic pathwayQ46970319
Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing.Q47744799
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature deathQ48110123
Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment.Q50626513
Acute exercise restores insulin clearance in diet-induced obese mice.Q51287028
The effects of a cafeteria diet on insulin production and clearance in rats.Q51377992
Exercise increases insulin clearance in healthy man and insulin-dependent diabetes mellitus patients.Q51577817
Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction.Q53111714
Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal MuscleQ58449836
Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptorsQ72564742
Interleukin-6 stimulates gluconeogenesis in primary cultures of rat hepatocytesQ72577466
Evidence for genetic linkage of Alzheimer's disease to chromosome 10qQ73316026
Isolation of an insulin-degrading enzyme from beef liverQ78556571
Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasisQ79734930
Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearanceQ83473619
Interleukin-6 mediates exercise-induced increase in insulin sensitivity in miceQ83954187
Exercise increases pancreatic β-cell viability in a model of type 1 diabetes through IL-6 signalingQ86574238
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)46750
P577publication date2017-04-21
P1433published inScientific ReportsQ2261792
P1476titleInterleukin-6 increases the expression and activity of insulin-degrading enzyme
P478volume7

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cites work (P2860)
Q93033050Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues
Q89577731Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD
Q49199697Insulin-degrading enzyme is not secreted from cultured cells
Q92133757Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size
Q57173246Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels
Q90136344Whey protein sweetened with Stevia rebaudiana Bertoni (Bert.) increases mitochondrial biogenesis markers in the skeletal muscle of resistance-trained rats

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