From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation.

scientific article

From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ICB.2014.16
P8608Fatcat IDrelease_rwlewrm7ojdqxpjknsiuz347me
P698PubMed publication ID24751614
P5875ResearchGate publication ID261769450

P50authorMartin WhithamQ57326654
P2093author name stringMark A Febbraio
Martin Pal
P2860cites workInterleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistanceQ84707922
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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersQ29617381
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A central role for JNK in obesity and insulin resistanceQ29619778
Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1Q30512877
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feedingQ33337750
Human IL6 enhances leptin action in miceQ33628094
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Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.Q34316238
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Directing transition from innate to acquired immunity: defining a role for IL-6.Q34449051
IL-6 is not necessary for the regulation of adipose tissue mitochondrial contentQ34512264
Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in miceQ34562825
Muscle as an endocrine organ: focus on muscle-derived interleukin-6.Q34857249
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Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivoQ37110520
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacitiesQ37129666
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A stress signaling pathway in adipose tissue regulates hepatic insulin resistanceQ41811449
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Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophagesQ42359004
Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness.Q42462340
Elevated IL-6 expression in CD4 T cells via PKCtheta and NF-kappaB induces Th2 cytokine productionQ42576908
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjectsQ42797512
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone.Q42834547
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin actionQ42917991
Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic miceQ42947751
Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat.Q43277580
Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-alpha levels after prolonged running.Q43540328
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretionQ43668496
Interleukin-6-deficient mice develop mature-onset obesityQ43851625
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6.Q44424615
IL-6 is not essential for exercise-induced increases in glucose uptake.Q44455523
Chronic exposure to interleukin-6 causes hepatic insulin resistance in miceQ44631827
Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesityQ44932358
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How obesity causes diabetes: not a tall taleQ45232061
Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in ratsQ46560266
Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese miceQ46663069
Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signalingQ46674674
Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behaviorQ47277520
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.Q48588727
Raised interleukin-6 levels in obese patientsQ48702097
Impaired immune and acute-phase responses in interleukin-6-deficient mice.Q52514391
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.Q52522262
Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor.Q54427494
Interleukin-6 modifies mRNA expression in mouse skeletal muscle.Q54610017
Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight LossQ56096259
IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammationQ56943138
Lifetime risk and projected population prevalence of diabetesQ58007870
The anti-CD20 antibody rituximab reduces the Th17 cell responseQ58998900
Evidence that interleukin-6 is produced in human skeletal muscle during prolonged runningQ59326390
Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal MuscleQ61908396
Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T CellsQ62658842
A comparative analysis of cytokine production and tolerance induction by bacterial lipopeptides, lipopolysaccharides and Staphyloccous aureus in human monocytesQ74254660
Exercise stimulates c-Jun NH2 kinase activity and c-Jun transcriptional activity in human skeletal muscleQ77472020
The JNK signal transduction pathwayQ79781771
Interleukin-6 mediates exercise-induced increase in insulin sensitivity in miceQ83954187
P433issue4
P921main subjectinterleukinsQ194908
P304page(s)331-339
P577publication date2014-03-11
P1433published inImmunology & Cell BiologyQ13731918
P1476titleFrom cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation
P478volume92

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