Human IL6 enhances leptin action in mice

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Human IL6 enhances leptin action in mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1012199164
P356DOI10.1007/S00125-009-1580-8
P932PMC publication ID2815798
P698PubMed publication ID19902173
P5875ResearchGate publication ID38078928

P2093author name stringM F White
K Copps
J Farhang
K D'Aquino
L Norquay
M Sadagurski
P2860cites workThe role of interleukin 6 in plasmacytomagenesisQ44941861
Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contractionQ44953893
An active metabolite of leflunomide, A77 1726, inhibits the production of serum amyloid A protein in human hepatocytesQ45253675
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.Q45877031
Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice.Q46163823
Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar ratsQ48435774
Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese miceQ48554833
Role of hepatic STAT3 in brain-insulin action on hepatic glucose productionQ48596967
IL-6-overexpression brings about growth impairment potentially through a GH receptor defect.Q52112602
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.Q52174749
Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans.Q54529003
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic miceQ58536315
Intracerebroventricular interleukin-6 treatment decreases body fat in ratsQ59649473
Interleukin-6 Regulates Human Adipose Tissue Lipid Metabolism and Leptin Productionin VitroQ60632247
Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency miceQ72989472
Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNFQ24297991
Inflammation and metabolic disordersQ27860923
Obesity and the regulation of energy balanceQ30080025
Cytokines in aging and exercise.Q33967340
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthQ34236816
IgG1 plasmacytosis in interleukin 6 transgenic miceQ34308376
Mechanisms of leptin action and leptin resistanceQ34701125
Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob miceQ34841988
Muscle as an endocrine organ: focus on muscle-derived interleukin-6.Q34857249
Interleukin-6 and chronic inflammationQ35578869
Acquiring signalling specificity from the cytokine receptor gp130.Q35617769
Leptin receptor signaling and the regulation of mammalian physiologyQ35641873
gp130 receptor ligands as potential therapeutic targets for obesityQ35723440
Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndromeQ36666161
The role of IL-6 in mediating the anti-inflammatory effects of exercise.Q36715171
Physiological roles of muscle-derived interleukin-6 in response to exerciseQ36783595
Critical role of STAT3 in leptin's metabolic actionsQ36800063
IL-6 signalling in exercise and diseaseQ36979813
SOCS proteins causing trouble in insulin actionQ37048806
Role of interleukin-6 signalling in glucose and lipid metabolismQ37048809
Interleukin-6 depletion selectively improves hepatic insulin action in obesityQ38327645
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseQ40227253
Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytesQ40278061
Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.Q40673661
Interleukin-6 induces cellular insulin resistance in hepatocytesQ40687381
Interleukin-6 stimulates lipolysis and fat oxidation in humansQ42169595
Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness.Q42462340
Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitroQ42825221
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretionQ43668496
Interleukin-6-deficient mice develop mature-onset obesityQ43851625
Divergent effects of leptin in mice susceptible or resistant to obesityQ44379378
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6.Q44424615
Chronic exposure to interleukin-6 causes hepatic insulin resistance in miceQ44631827
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivoQ44816750
P433issue3
P304page(s)525-535
P577publication date2009-11-10
P1433published inDiabetologiaQ5270140
P1476titleHuman IL6 enhances leptin action in mice
P478volume53

Reverse relations

cites work (P2860)
Q39393721A case of anorexia nervosa with comorbid Crohn's disease: beneficial effects of anti-TNF-α therapy?
Q30357655Adipocytokines in obesity and metabolic disease.
Q38784887Adipokines in Healthy Skeletal Muscle and Metabolic Disease
Q36560588Altered response of skeletal muscle to IL-6 in type 2 diabetic patients
Q52669792Association between high serum carcinoembryonic antigen and clinical state of male anorexia nervosa: A case report.
Q92343438Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone
Q34316238Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.
Q38025974Continuous glucose monitoring in children and adolescents
Q35195052Deletion of interleukin-6 improves pyruvate tolerance without altering hepatic insulin signaling in the leptin receptor-deficient mouse
Q33968320Disassociated relation between plasma tumor necrosis factor-alpha, interleukin-6 and increased body weight in Amerindian women: A long-term prospective study of natural body weight variation and impaired glucose tolerance
Q29619888Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
Q58107270Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism
Q30361595From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation.
Q48200213Functional interleukin-6 receptor-α is located in tanycytes at the base of the third ventricle.
Q39015204Gastrointestinal comorbidities which complicate the treatment of anorexia nervosa
Q36410031Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice
Q34086574HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance
Q33600513Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons
Q27323584IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition
Q56240296IL-6 regulates exercise and training-induced adaptations in subcutaneous adipose tissue in mice
Q37968599IL-6/IL-6R as a potential key signaling pathway in prostate cancer development
Q58725702IL-6: A Potential Role in Cardiac Metabolic Homeostasis
Q64387657IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects
Q82249175IL6 as a mediator of insulin resistance: fat or fiction?
Q35993401IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action
Q41665611In vitro anti-inflammatory effects of citrulline on peritoneal macrophages in Zucker diabetic fatty rats
Q38732966Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction
Q33865096Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms
Q45288120Inter-relation between interleukin (IL)-1, IL-6 and body fat regulating circuits of the hypothalamic arcuate nucleus.
Q34857481Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.
Q91592796Interleukin-6 in the central amygdala is bioactive and co-localised with glucagon-like peptide-1 receptor
Q26866208Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
Q47376918Interleukin-6 regulates the expression of hypothalamic neuropeptides involved in body weight in a gender-dependent way.
Q84707922Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
Q37594442Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis
Q59326168Is Interleukin-6 Receptor Blockade the Holy Grail for Inflammatory Diseases?
Q38319544Leptin and leucine synergistically regulate protein metabolism in C2C12 myotubes and mouse skeletal muscles
Q57462637Leptin and the intervertebral disc: a biochemical link exists between obesity, intervertebral disc degeneration and low back pain-an in vitro study in a bovine model
Q53508307Leukemia inhibitory factor increases glucose uptake in mouse skeletal muscle.
Q33701511Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis
Q35273848Loss of Ron receptor signaling leads to reduced obesity, diabetic phenotypes and hepatic steatosis in response to high-fat diet in mice
Q35123484Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.
Q34031701Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training
Q51541906Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models.
Q34132288Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.
Q36906688Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer
Q34265667Muscles, exercise and obesity: skeletal muscle as a secretory organ
Q38199992Myokines in insulin resistance and type 2 diabetes.
Q83965043Oncostatin M produced in Kupffer cells in response to PGE2: possible contributor to hepatic insulin resistance and steatosis
Q38141219Physical inactivity, insulin resistance, and the oxidative-inflammatory loop
Q35905154Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies.
Q42011586Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.
Q91736923Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
Q34893465Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk
Q47650330Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production
Q34166632Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
Q38134113Targeting gp130 to prevent inflammation and promote insulin action.
Q37715588The Baf60c/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity
Q38992755The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism
Q26770548The role of gp130 receptor cytokines in the regulation of metabolic homeostasis
Q35588690Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice
Q37950733Why do anti-inflammatory therapies fail to improve insulin sensitivity?