| scholarly article | Q13442814 |
| P50 | author | Richard F. Kefford | Q46460242 |
| Helen Rizos | Q57017610 | ||
| P2093 | author name string | Therese M Becker | |
| Sieu L Tran | |||
| Lyndee L Scurr | |||
| Sebastian Haferkamp | |||
| P2860 | cites work | Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a) | Q24293520 |
| A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6 | Q24295528 | ||
| A large-scale RNAi screen in human cells identifies new components of the p53 pathway | Q24319883 | ||
| Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a | Q24324559 | ||
| Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1 | Q24540711 | ||
| A biomarker that identifies senescent human cells in culture and in aging skin in vivo | Q24562644 | ||
| Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging | Q24642706 | ||
| Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence | Q24650807 | ||
| Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis | Q24791830 | ||
| Mutations of the BRAF gene in human cancer | Q27860760 | ||
| A system for stable expression of short interfering RNAs in mammalian cells | Q27860875 | ||
| CDK inhibitors: positive and negative regulators of G1-phase progression | Q27860983 | ||
| Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network | Q27863386 | ||
| Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants | Q28287782 | ||
| Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry | Q28509466 | ||
| Distinct sets of genetic alterations in melanoma | Q29614965 | ||
| A third-generation lentivirus vector with a conditional packaging system | Q29616120 | ||
| Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints | Q29617405 | ||
| Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication | Q29617915 | ||
| BRAFE600-associated senescence-like cell cycle arrest of human naevi | Q29619550 | ||
| Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF | Q29619663 | ||
| Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence | Q29620428 | ||
| The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. | Q33889383 | ||
| Stress signals utilize multiple pathways to stabilize p53 | Q33963268 | ||
| High frequency of BRAF mutations in nevi | Q34160519 | ||
| The retinoblastoma tumour suppressor in development and cancer | Q34161991 | ||
| Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts | Q34250440 | ||
| Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts | Q34286570 | ||
| Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). | Q34574445 | ||
| Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions | Q35076939 | ||
| p19ARF links the tumour suppressor p53 to Ras | Q57562848 | ||
| Mutations in theINK4a/ARFMelanoma Susceptibility Locus Functionally Impair p14ARF | Q58024946 | ||
| Human melanocytes cultured from nevi and melanomas | Q68966287 | ||
| p16 INK4a can initiate an autonomous senescence program | Q73673952 | ||
| Human melanocyte senescence and melanoma susceptibility genes | Q35146545 | ||
| The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer | Q35191588 | ||
| Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization | Q35207910 | ||
| Senescence of human fibroblasts induced by oncogenic Raf. | Q35210205 | ||
| Reversal of human cellular senescence: roles of the p53 and p16 pathways | Q35561999 | ||
| Mutational analysis of the N-ras, p53, p16INK4a, CDK4, and MC1R genes in human congenital melanocytic naevi | Q35571122 | ||
| Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts | Q35927191 | ||
| Cutaneous melanoma | Q36049052 | ||
| Rb/E2F: a two-edged sword in the melanocytic system | Q36178390 | ||
| Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo | Q36538322 | ||
| Malignant melanoma: genetics and therapeutics in the genomic era. | Q36567158 | ||
| p16INK4a-induced senescence is disabled by melanoma-associated mutations | Q36971412 | ||
| Cellular senescence in vivo: a barrier to tumorigenesis | Q37114283 | ||
| MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. | Q38345102 | ||
| Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression | Q39129632 | ||
| INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence | Q39647398 | ||
| Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors. | Q39884649 | ||
| C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells | Q39954044 | ||
| Distinct roles for p107 and p130 in Rb-independent cellular senescence | Q39991210 | ||
| Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. | Q40014237 | ||
| p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression. | Q40646165 | ||
| Production and concentration of pseudotyped HIV-1-based gene transfer vectors | Q40874845 | ||
| Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. | Q40928334 | ||
| p21WAF1 mutations and human malignancies | Q41557350 | ||
| Cellular senescence in naevi and immortalisation in melanoma: a role for p16? | Q42016240 | ||
| The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. | Q42123048 | ||
| ATM is a target for positive regulation by E2F-1. | Q42806424 | ||
| Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts | Q42815554 | ||
| A negative feedback signaling network underlies oncogene-induced senescence | Q43116108 | ||
| Relative mitogenic activities of wild-type and retinoblastoma binding-defective SV40 T antigens in serum-deprived and senescent human diploid fibroblasts. | Q44049265 | ||
| Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures | Q44478684 | ||
| Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis | Q47314663 | ||
| Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells. | Q52535129 | ||
| Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes | Q53374378 | ||
| Role of the INK4a locus in tumor suppression and cell mortality. | Q53455197 | ||
| Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. | Q53600237 | ||
| Escape from premature senescence is not sufficient for oncogenic transformation by Ras. | Q54021692 | ||
| High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL | Q56437244 | ||
| The tumor-suppressive functions of the human INK4A locus | Q57187959 | ||
| P433 | issue | 6 | |
| P304 | page(s) | 542-556 | |
| P577 | publication date | 2009-05-16 | |
| P1433 | published in | Aging | Q2845875 |
| P1476 | title | The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence | |
| P478 | volume | 1 |
| Q36823687 | A prognostic signature of G(2) checkpoint function in melanoma cell lines |
| Q36096818 | A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines |
| Q39362670 | Absence of distinguishing senescence traits in human melanocytic nevi |
| Q35853227 | Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction |
| Q36019964 | Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation |
| Q33893832 | Cell senescence in myxoid/round cell liposarcoma |
| Q37828383 | Cellular senescence as a target in cancer control |
| Q38055308 | Controversial aspects of oncogene-induced senescence |
| Q35640301 | Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells |
| Q38120311 | DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma. |
| Q27026235 | Disruptive chemicals, senescence and immortality |
| Q34803805 | EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression |
| Q36556389 | Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines |
| Q35755632 | Effects of p21 Gene Down-Regulation through RNAi on Antler Stem Cells In Vitro |
| Q41342227 | Integration of ALV into CTDSPL and CTDSPL2 genes in B-cell lymphomas promotes cell immortalization, migration and survival |
| Q35556981 | Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells |
| Q61799432 | Jumonji C Demethylases in Cellular Senescence |
| Q92832169 | LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts |
| Q34026182 | Mechanisms of chromosomal instability in melanoma |
| Q37139115 | Mechanisms of radiation toxicity in transformed and non-transformed cells |
| Q35740772 | Molecular damage in cancer: an argument for mTOR-driven aging |
| Q37984547 | Narrowing the knowledge gaps for melanoma |
| Q36339260 | Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma. |
| Q40546752 | Nevus senescence. |
| Q37210779 | Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion |
| Q35694629 | P16/p53 expression and telomerase activity in immortalized human dental pulp cells. |
| Q36652026 | PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma |
| Q35541658 | PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells |
| Q47927484 | Pathways from senescence to melanoma: focus on MITF sumoylation. |
| Q37777015 | Pathways of oncogene-induced senescence in human melanocytic cells |
| Q39139826 | Phenotype-independent effects of retroviral transduction in human dental pulp stem cells. |
| Q37138585 | Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence |
| Q39224402 | Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion |
| Q38430876 | Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression |
| Q51702688 | Telomerase expression in amyotrophic lateral sclerosis (ALS) patients. |
| Q38346325 | The Intricate Interplay between Mechanisms Underlying Aging and Cancer |
| Q39271171 | The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence |
| Q34825182 | miR-22 represses cancer progression by inducing cellular senescence |
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