PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells

scientific article published on 8 August 2011

PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2011.339
P932PMC publication ID3213274
P698PubMed publication ID21822300
P5875ResearchGate publication ID51552754

P50authorMarisol SoengasQ42911215
P2093author name stringM A Nikiforov
J R Marshall
D Zhuang
R C Sears
S Mannava
C D Morrison
J A Wawrzyniak
E E Fink
A R Omilian
J C Miecznikowski
P2860cites workCIP2A expression is increased in prostate cancerQ21198842
The ubiquitin-specific protease USP28 is required for MYC stabilityQ24308568
Identification of c-MYC as a target of the APC pathwayQ24310637
The Axin1 scaffold protein promotes formation of a degradation complex for c-MycQ24314734
Identification of PP2A complexes and pathways involved in cell transformationQ24316472
CIP2A inhibits PP2A in human malignanciesQ24319683
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 betaQ24319688
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cellsQ24321642
Myc pathways provoking cell suicide and cancerQ28190322
Determinants of BRAF mutations in primary melanomasQ28191720
Distinct sets of genetic alterations in melanomaQ29614965
c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnoverQ73520938
BRAFE600-associated senescence-like cell cycle arrest of human naeviQ29619550
Control of cell proliferation by Myc family genesQ33548120
The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescenceQ33588743
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformationQ33591386
MYC oncogenes and human neoplastic diseaseQ33667340
Tumor suppressors and oncogenes in cellular senescence.Q33930350
c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cellsQ33962550
High frequency of BRAF mutations in neviQ34160519
The Mad and Myc basic domains are functionally equivalentQ34171815
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cellsQ34803825
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradationQ34835596
MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.Q34983172
eIF-4E expression and its role in malignancies and metastases.Q35750118
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivationQ35928960
Selective evolutionary pressure from the tissue microenvironment drives tumor progressionQ36206974
The WNT/Beta-catenin pathway in melanomaQ36251062
Involvement of PP2A in viral and cellular transformationQ36318172
Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological functionQ36580032
The Oscar-worthy role of Myc in apoptosisQ36582963
Oncogene-induced cell senescence--halting on the road to cancerQ36587198
Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosisQ36663762
Melanoma biology and new targeted therapyQ36742015
Understanding signaling cascades in melanomaQ37034487
MYC-induced cancer cell energy metabolism and therapeutic opportunitiesQ37438881
Pathways of oncogene-induced senescence in human melanocytic cellsQ37777015
Werner syndrome protein limits MYC-induced cellular senescenceQ39895677
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cellsQ39954044
Inactivation of hCDC4 can cause chromosomal instabilityQ40582502
Skp2 regulates Myc protein stability and activityQ40644685
Ras enhances Myc protein stability.Q40967066
Proteins of the Myc network: essential regulators of cell growth and differentiation.Q41035974
c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycleQ42115767
IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.Q42265040
Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulationQ43240765
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.Q53600237
P4510describes a project that usesImageQuantQ112270642
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)1484-1492
P577publication date2011-08-08
P1433published inOncogeneQ1568657
P1476titlePP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells
P478volume31

Reverse relations

cites work (P2860)
Q58796907Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma
Q38617799All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase
Q36443322B'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase
Q42500610CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes
Q35755402Cellular localization of CIP2A determines its prognostic impact in superficial spreading and nodular melanoma
Q38055308Controversial aspects of oncogene-induced senescence
Q36495207Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence
Q38904928Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options.
Q41585228Detection of Nucleotide Disbalance in Cells Undergoing Oncogene-Induced Senescence
Q26865711LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential
Q38193043MYC degradation
Q37984547Narrowing the knowledge gaps for melanoma
Q38722990P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells
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Q36288343Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity.
Q38103646Protein phosphatase 2A: a target for anticancer therapy
Q30657002RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development
Q30464719Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback Pathway
Q92447468STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations
Q36072016Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress
Q42380380The Immortal Senescence
Q38237693Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy?

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