Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

scientific article

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NATURE12744
P932PMC publication ID4017780
P698PubMed publication ID24172905
P5875ResearchGate publication ID258203315

P50authorDennis R. BurtonQ56331320
Hui-Wen ChangQ56447041
Michael S SeamanQ56474031
Thiago Yukio Kikuchi OliveiraQ56490386
Dan H. BarouchQ60489346
Mark G. LewisQ66732036
Joseph P. NkololaQ68690722
Pascal PoignardQ72530329
Kathryn E StephensonQ80341692
Florian KleinQ89519296
Karthik ShekharQ112971454
Erica N BorducchiQ114291820
Brian MoldtQ114313962
Michel C. NussenzweigQ24804686
P2093author name stringKaitlin M Smith
Arup K Chakraborty
James R Perry
James B Whitney
Srisowmya Sanisetty
Jinyan Liu
Stephen Blackmore
Sanjana Gupta
Matthew Beck
Crystal Cabral
Jeffrey Y Smith
William Rinaldi
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Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodiesQ35857254
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Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studiesQ36171962
Gag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following simian immunodeficiency virus challenges of vaccinated rhesus monkeysQ36246220
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse virusesQ36693991
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HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized miceQ37236504
Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaquesQ37252831
P433issue7475
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
monoclonal antibodyQ422248
P304page(s)224-228
P577publication date2013-10-30
P1433published inNatureQ180445
P1476titleTherapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
P478volume503

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Q64096904Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features
Q57093617Preventive and therapeutic features of broadly neutralising monoclonal antibodies against HIV-1
Q42215329Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.
Q94547060Promise and Progress of an HIV-1 Cure by Adeno-Associated Virus Vector Delivery of Anti-HIV-1 Biologics
Q37621530Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies
Q35569901Prospects for engineering HIV-specific antibodies for enhanced effector function and half-life
Q35974961Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques
Q41933482Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.
Q58585537Randomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ART
Q35973587Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys
Q92376528Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection
Q50351069Rapid Sequencing of Complete env Genes from Primary HIV-1 Samples.
Q34174815Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36.
Q28068946Recent Progress toward Engineering HIV-1-Specific Neutralizing Monoclonal Antibodies
Q26766628Recent update in HIV vaccine development
Q38718435Reduced Potency and Incomplete Neutralization of Broadly Neutralizing Antibodies against Cell-to-Cell Transmission of HIV-1 with Transmitted Founder Envs
Q59355458Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117
Q89467843Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
Q28075274Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
Q48507985Review of Current Cell-Penetrating Antibody Developments for HIV-1 Therapy.
Q56995988Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
Q50011228Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies.
Q89996173Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial
Q40076041Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers
Q35641498Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.
Q35980789Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules
Q52338929Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.
Q27683553Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers
Q34782382Structural evolution of glycan recognition by a family of potent HIV antibodies
Q26829461Structural insights on the role of antibodies in HIV-1 vaccine and therapy
Q30358358Structural plasticity of the Semliki Forest virus glycome upon interspecies transmission.
Q35102339Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection
Q58583636Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition
Q34361120Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge
Q48270835Systematic Synthesis and Binding Study of HIV V3 Glycopeptides Reveal the Fine Epitopes of Several Broadly Neutralizing Antibodies.
Q37338339Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization
Q37246321Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies
Q52570452Tandem bispecific broadly neutralizing antibody - a novel approach to HIV-1 treatment.
Q35985519Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability
Q35833324Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells
Q59357558Targeting the HIV-1 Spike and Coreceptor with Bi- and Trispecific Antibodies for Single-Component Broad Inhibition of Entry
Q54210140Targeting the Latent Reservoir for HIV-1.
Q64060305The Antibodiome-Mapping the Humoral Immune Response to HIV
Q35686970The Broad Neutralizing Antibody Responses after HIV-1 Superinfection Are Not Dominated by Antibodies Directed to Epitopes Common in Single Infection
Q38505356The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children
Q99637166The influence of proline isomerization on potency and stability of anti-HIV antibody 10E8
Q52430553The latest evidence for possible HIV-1 curative strategies.
Q38209477The maturation of antibody technology for the HIV epidemic
Q33997395The role of Fc receptors in HIV infection and vaccine efficacy.
Q37113972The role of Fc receptors in HIV prevention and therapy
Q26797466The role of Fc-FcγR interactions in IgG-mediated microbial neutralization
Q39169410Therapeutic HIV vaccines: prior setbacks, current advances, and future prospects
Q55084408Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys.
Q47555891Therapeutic efficacy of vectored PGT121 gene delivery in HIV-1-infected humanized mice
Q38971085Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy
Q36972591Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding
Q36515149Towards HIV-1 remission: potential roles for broadly neutralizing antibodies
Q42205072Towards a cure for HIV--are we making progress?
Q40932044Towards a vaccine against HIV: antibodies raised by a gp41 peptide neutralize the virus and inhibit pathogenesis
Q40972007Trying to cure HIV with immunotherapy: not so simple
Q34991017Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope
Q93078490Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections
Q92479131Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies
Q38764543Use of broadly neutralizing antibodies for HIV-1 prevention
Q28077662Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research
Q36628369V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1
Q35071821Vaccine-induced plasmablast responses in rhesus macaques: phenotypic characterization and a source for generating antigen-specific monoclonal antibodies
Q27007529Vaccines for the 21st century
Q30390904Vaccines, new opportunities for a new society
Q35664155Vectored antibody gene delivery for the prevention or treatment of HIV infection
Q36961578Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.
Q35823060Viremic HIV Controllers Exhibit High Plasmacytoid Dendritic Cell-Reactive Opsonophagocytic IgG Antibody Responses against HIV-1 p24 Associated with Greater Antibody Isotype Diversification
Q40187584Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys
Q35540033Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties
Q26800992What Will It Take to Cure HIV?
Q33772637Which Antibody Functions are Important for an HIV Vaccine?
Q37627236Why cure, why now?
Q47564080eCD4-Ig promotes ADCC activity of sera from HIV-1-infected patients

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