Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

scientific article

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1084/JEM.20151960
P3181OpenCitations bibliographic resource ID1230830
P932PMC publication ID4821650
P698PubMed publication ID27022144
P5875ResearchGate publication ID299476700

P50authorRino RappuoliQ2154243
P2093author name stringEnnio De Gregorio
Oretta Finco
Matthew J. Bottomley
Ugo D’Oro
P2860cites workMF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.Q41337351
Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in miceQ42218132
Cross-neutralization of four paramyxoviruses by a human monoclonal antibodyQ42275949
Secondary immunization generates clonally related antigen-specific plasma cells and memory B cells.Q42671244
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirusQ47957009
A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.Q51564288
Structural vaccinology starts to deliverQ57988219
Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. The IMpact-RSV Study GroupQ77300551
Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cellsQ21562507
A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individualsQ24560010
Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodiesQ24561905
A highly conserved neutralizing epitope on group 2 influenza A virusesQ24630467
Rapid cloning of high-affinity human monoclonal antibodies against influenza virusQ24644672
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A virusesQ24649949
Antibody recognition of a highly conserved influenza virus epitopeQ24655932
Self-assembling protein nanoparticles in the design of vaccinesQ26767097
Structural and Computational Biology in the Design of Immunogenic Vaccine AntigensQ26777382
Antibody responses to envelope glycoproteins in HIV-1 infectionQ26991572
Serology in the 21st century: the molecular-level analysis of the serum antibody repertoireQ26997997
Antibodies in HIV-1 vaccine development and therapyQ27011574
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusQ27644501
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodiesQ27644515
Structural basis of respiratory syncytial virus neutralization by motavizumabQ27659146
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogensQ37456354
A multi-component meningococcal serogroup B vaccine (4CMenB): the clinical development programQ37471668
Identification and characterization of the constituent human serum antibodies elicited by vaccination.Q37587683
Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmissionQ37708741
Prospects for defined epitope vaccines for respiratory syncytial virusQ37721415
Systems analysis of adaptive immunity by utilization of high-throughput technologiesQ37875449
New approaches to HIV vaccine developmentQ38521826
Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programmingQ39761197
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infectionQ40173380
Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial VirusQ27667750
Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titersQ27667876
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 BindingQ27670829
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutininsQ27671165
Highly Conserved Protective Epitopes on Influenza B VirusesQ27671404
Rational HIV Immunogen Design to Target Specific Germline B Cell ReceptorsQ27677104
Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing AntibodyQ27677570
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial VirusQ27680499
A common solution to group 2 influenza virus neutralizationQ27680873
Proof of principle for epitope-focused vaccine designQ27681593
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protectionQ27701887
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogenQ27701889
Whole-genome random sequencing and assembly of Haemophilus influenzae RdQ27860765
Protein Crystallography in Vaccine Research and DevelopmentQ28087528
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41Q28236154
Edward Jenner's Inquiry; a bicentenary analysisQ28297101
Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human AntibodiesQ28550400
HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimersQ28647225
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetQ29547347
Broad neutralization coverage of HIV by multiple highly potent antibodiesQ29615361
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibodyQ29618366
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1Q29619511
Predominant autoantibody production by early human B cell precursorsQ29619656
Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysisQ29619821
Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangementsQ30364187
Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccineQ30388038
A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutininQ30406095
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodiesQ30430925
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporterQ30498133
Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategiesQ33328393
A method for identification of HIV gp140 binding memory B cells in human bloodQ33394829
Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complexQ33558361
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeysQ33597744
Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo.Q33860721
Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.Q33892877
High throughput cellular screens to interrogate the human T and B cell repertoiresQ33907471
Antibody-secreting B cells in HIV infectionQ33914185
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemiaQ34049077
Convergent antibody signatures in human dengueQ34060276
Edward Jenner and the eradication of smallpoxQ34066116
Reverse vaccinologyQ34069770
Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults: analysis of the variable heavy chain repertoireQ34111761
Vaccines: science, health, longevity, and wealthQ34120026
Influenza vaccines for the futureQ34150283
B-cell-lineage immunogen design in vaccine development with HIV-1 as a case studyQ34273373
Respiratory syncytial virus infection in elderly and high-risk adultsQ34414401
Structure and function of respiratory syncytial virus surface glycoproteins.Q34414405
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interfaceQ34473958
Identification of antigen-specific B cell receptor sequences using public repertoire analysisQ34749062
Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodiesQ34753135
Antibodies, viruses and vaccinesQ34810301
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individualsQ34962766
Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibodyQ35170702
Antibody-based protection against HIV infection by vectored immunoprophylaxisQ35658856
Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical interventionQ35778982
Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypesQ35943392
Identification of human neutralizing antibodies that bind to complex epitopes on dengue virionsQ35982791
The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigensQ35989852
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin MiceQ36159067
HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.Q36345558
A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin.Q36363177
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloningQ36459907
Fully human monoclonal antibodies from antibody secreting cells after vaccination with Pneumovax®23 are serotype specific and facilitate opsonophagocytosisQ36565432
Isolation of human monoclonal antibodies from peripheral blood B cellsQ36833296
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.Q36961578
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligationQ36977531
Structure-based antigen design: a strategy for next generation vaccinesQ37314536
A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificitiesQ37444686
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activityQ37448171
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
vaccineQ134808
biomedical investigative techniqueQ66648976
vaccine engineeringQ14861085
P304page(s)469-81
P577publication date2016-04-04
P1433published inJournal of Experimental MedicineQ3186912
P1476titleReverse vaccinology 2.0: Human immunology instructs vaccine antigen design
P478volume213

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cites work (P2860)
Q58735723A Gene-Based Positive Selection Detection Approach to Identify Vaccine Candidates Using as a Test Case Protozoan Pathogen
Q94491384A cutting-edge immunoinformatics approach for design of multi-epitope oral vaccine against dreadful human malaria
Q63984735A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection
Q55053671A qualitatively validated mathematical-computational model of the immune response to the yellow fever vaccine.
Q52317335An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus.
Q92965786Antibodies against Plasmodium falciparum malaria at the molecular level
Q96641551Application of System Biology to Explore the Association of Neprilysin, Angiotensin-Converting Enzyme 2 (ACE2), and Carbonic Anhydrase (CA) in Pathogenesis of SARS-CoV-2
Q38768895Applying proteomics to tick vaccine development: where are we?
Q57817461Bacterial Vaccine Antigen Discovery in the Reverse Vaccinology 2.0 Era: Progress and Challenges
Q58781552Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design
Q98188950Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2
Q63246442Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
Q39197155Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?
Q55340953Changing Priorities in Vaccinology: Antibiotic Resistance Moving to the Top.
Q55003572Computational Modeling of Hepatitis C Virus Envelope Glycoprotein Structure and Recognition.
Q90650313Cross-Reactive Bactericidal Antimeningococcal Antibodies Can Be Isolated From Convalescing Invasive Meningococcal Disease Patients Using Reverse Vaccinology 2.0.
Q40200645CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface
Q48095992Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.
Q41912569Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA
Q92629953Current trends in targeted therapy for drug-resistant infections
Q49849737Deploy vaccines to fight superbugs.
Q92184345Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes
Q47158624EMA and EFSA Joint Scientific Opinion on measures to reduce the need to use antimicrobial agents in animal husbandry in the European Union, and the resulting impacts on food safety (RONAFA)
Q49886229Ecology and evolution of Mycobacterium tuberculosis.
Q42377340Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model
Q40047469Eliminating acute rheumatic fever and rheumatic heart disease
Q47155273Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design
Q38829564Fighting Neisseria meningitidis: past and current vaccination strategies
Q90696470First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
Q53056444Genome-wide identification of novel vaccine candidates for Plasmodium falciparum malaria using integrative bioinformatics approaches.
Q54233532Global epidemiology of serogroup B meningococcal disease and opportunities for prevention with novel recombinant protein vaccines.
Q41936503Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development
Q92237228Immunoinformatics Approach to Design a Novel Epitope-Based Oral Vaccine Against Helicobacter pylori
Q90249670Immunoinformatics and Vaccine Development: An Overview
Q90466213Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity
Q50208609Innovation Partnership for a Roadmap on Vaccines in Europe (IPROVE): A vision for the vaccines of tomorrow.
Q56515654Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials
Q93063721Lessons for general vaccinology research from attempts to develop an HIV vaccine
Q39062411Mathematical modeling based on ordinary differential equations: A promising approach to vaccinology
Q40109161Nanoparticle orientationally displayed antigen epitopes improve neutralizing antibody level in a model of porcine circovirus type 2.
Q63362961Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities
Q40470909One vaccinology? Overcoming challenges in vaccine development.
Q93081608Peptide-Based Vaccination for Antibody Responses Against HIV
Q62630863Peptides for Infectious Diseases: From Probe Design to Diagnostic Microarrays
Q47700986Perspectives in allergen immunotherapy: 2017 and beyond
Q59599346Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Complex
Q64115920Prioritization of potential vaccine targets using comparative proteomics and designing of the chimeric multi-epitope vaccine against Pseudomonas aeruginosa
Q37621530Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies
Q64983102Protein and Glycan Mimicry in HIV Vaccine Design.
Q104105760Rapid developability assessments to formulate recombinant protein antigens as stable, low-cost, multi-dose vaccine candidates: Case-study with non-replicating rotavirus (NRRV) vaccine antigens
Q59806879Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens
Q92652148Reverse vaccinology and subtractive genomics reveal new therapeutic targets against Mycoplasma pneumoniae: a causative agent of pneumonia
Q97885825Second career of a biosynthetic enzyme: Lumazine synthase as a virus-like nanoparticle in vaccine development
Q24672537Some vexations that challenge viral immunology
Q89446935Structure-based immunogen design-leading the way to the new age of precision vaccines
Q90169965Systems Biological Analysis of Immune Response to Influenza Vaccination
Q30238729Systems serology for evaluation of HIV vaccine trials
Q94502896São Paulo School of Advanced Sciences on Vaccines: an overview
Q92487060TIPICO IX: report of the 9th interactive infectious disease workshop on infectious diseases and vaccines
Q58691534Targeting Difficult Protein-Protein Interactions with Plain and General Computational Approaches
Q100466517Technological approaches to streamline vaccination schedules, progressing towards single-dose vaccines
Q60301819Technologies to address antimicrobial resistance
Q57094341The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen
Q55518743Towards conformational fidelity of a quaternary HIV-1 epitope: computational design and directed evolution of a minimal V1V2 antigen.
Q39170404Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection
Q92538472Using Omics Technologies and Systems Biology to Identify Epitope Targets for the Development of Monoclonal Antibodies Against Antibiotic-Resistant Bacteria
Q40130441Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies
Q92564603Vaccine Evolution and Its Application to Fight Modern Threats
Q36413834Vaccine candidate discovery for the next generation of malaria vaccines.
Q51416013Vaccines Meet Big Data: State-of-the-Art and Future Prospects. From the Classical 3Is ("Isolate-Inactivate-Inject") Vaccinology 1.0 to Vaccinology 3.0, Vaccinomics, and Beyond: A Historical Overview.
Q40346058What Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise
Q58804243When designing vaccines, consider the starting material: the human B cell repertoire
Q30829948Whither vaccines?
Q96230739[Vaccine of the future]

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