Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity

scientific article published on 17 March 2020

Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VACCINE.2020.03.010
P932PMC publication ID7132531
P698PubMed publication ID32192810

P50authorMargaret E. AckermanQ57012155
Chris Bailey-KelloggQ89469549
P2093author name stringMichael S Seaman
Susan Zolla-Pazner
Karl E Griswold
Susan K Eszterhas
Seth A Brooks
Jennifer I Lai
Chengzi Guo
P2860cites workA Blueprint for HIV Vaccine DiscoveryQ26829865
Antibodies in HIV-1 vaccine development and therapyQ27011574
Structure and Dynamics of the Native HIV-1 Env TrimerQ27027570
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Q27644478
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2Q27675879
Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individualsQ27677941
Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16Q27678312
Crystal Structure of a Soluble Cleaved HIV-1 Envelope TrimerQ27680496
Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIVQ27681527
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen designQ28075274
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodiesQ28299280
High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samplesQ28389941
Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope GlycoproteinQ29306052
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantationQ29615068
Immune-correlates analysis of an HIV-1 vaccine efficacy trialQ29617377
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sitesQ29619017
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1Q29619511
The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta BarrelQ30152923
V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144.Q33874253
HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activitiesQ33900395
Elicitation of HIV-1-neutralizing antibodies against the CD4-binding site.Q34133551
Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized miceQ34180174
Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1Q34292765
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2Q34298408
Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.Q34434854
Epitope mapping of conformational V2-specific anti-HIV human monoclonal antibodies reveals an immunodominant site in V2.Q34907398
DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP).Q35935131
Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trialsQ36083337
The development of CD4 binding site antibodies during HIV-1 infectionQ36155396
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodiesQ36262823
Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene familyQ36363231
Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivoQ36414891
Challenges for structure-based HIV vaccine designQ37667763
HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitisQ38357177
Fragments of the V1/V2 domain of HIV-1 glycoprotein 120 engineered for improved binding to the broadly neutralizing PG9 antibodyQ38756259
Distinct mechanisms regulate exposure of neutralizing epitopes in the V2 and V3 loops of HIV-1 envelopeQ38962226
Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complexQ39593524
Non-neutralizing Antibodies Targeting the V1V2 Domain of HIV Exhibit Strong Antibody-Dependent Cell-mediated Cytotoxic Activity.Q41924059
HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among VaccineesQ47547483
Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated SHIV challenges.Q51743315
Towards conformational fidelity of a quaternary HIV-1 epitope: computational design and directed evolution of a minimal V1V2 antigen.Q55518743
V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC ActivityQ60959639
Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimersQ64228820
Humoral Response to the HIV-1 Envelope V2 Region in a Thai Early Acute Infection Cohort.Q64967037
Removal of endotoxin from protein solutions by phase separation using Triton X-114Q68480102
Factors limiting the immunogenicity of HIV-1 gp120 envelope glycoproteinsQ80966875
Anti-V2 antibody deficiency in individuals infected with HIV-1 in CameroonQ91144554
Correction: Trinh, H.V., et al. Humoral Response to the HIV-1 Envelope V2 Region in a Thai Early Acute Infection Cohort. Cells 2019, 8, 365Q92590076
Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing AntibodiesQ92719597
P433issue18
P1104number of pages11
P304page(s)3436-3446
P577publication date2020-03-17
P1433published inVaccineQ7907941
P1476titleInduction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity
P478volume38

Search more.