Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

scientific article published on 6 December 2017

Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.30051
P932PMC publication ID5749957
P698PubMed publication ID29210669

P50authorChing-Lin HsiehQ56797144
Yung-Fu ChangQ85640734
Richard E GillilanQ88295022
Christopher P PtakQ44267175
P2093author name stringTing Li
Robert E Oswald
Yi-Pin Lin
Sean P McDonough
Andrew Tseng
Igor Massahiro de Souza Suguiura
Tepyuda Sritrakul
P2860cites workStructural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)Q21134757
Global Morbidity and Mortality of Leptospirosis: A Systematic ReviewQ21144770
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Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogenQ24597151
Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogenQ24672690
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Proof of principle for epitope-focused vaccine designQ27681593
NMR Solution Structure of the Terminal Immunoglobulin-like Domain from the Leptospira Host-Interacting Outer Membrane Protein, LigBQ27684840
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Development and characterization of a monoclonal antibody specific for bovine CD209.Q46785910
Immunogenicity of the recombinant leptospiral putative outer membrane proteins as vaccine candidates.Q51794020
Human Cardiac Myosin Binding Protein C: Structural Flexibility within an Extended Modular ArchitectureQ57979770
Structural vaccinology starts to deliverQ57988219
Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BPQ58274952
Differential IgG-binding characteristics of staphylococcal protein A, streptococcal protein G, and a chimeric protein AGQ69292487
New developments in the ATSAS program package for small-angle scattering data analysisQ29616858
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solutionQ29619405
Virulence of the zoonotic agent of leptospirosis: still terra incognita?Q30235431
Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopyQ30375263
Synchrotron-based small-angle X-ray scattering of proteins in solutionQ30654818
Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamilyQ30815174
The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infectionQ30847648
Leptospira immunoglobulin-like protein B (LigB) binding to the C-terminal fibrinogen αC domain inhibits fibrin clot formation, platelet adhesion and aggregationQ33393580
Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp.Q33616781
Use of luminescent Leptospira interrogans for enumeration in biological assaysQ33909373
Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectinQ33928192
High-throughput biological small-angle X-ray scattering with a robotically loaded capillary cellQ34234839
Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complementQ34388016
Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibodyQ34661129
Upgrade of MacCHESS facility for X-ray scattering of biological macromolecules in solutionQ34953255
A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccinationQ34993283
Ambiguity assessment of small-angle scattering curves from monodisperse systems.Q35622941
Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans.Q35827083
The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosisQ36013519
Leptospira Immunoglobulin-Like Protein B (LigB) Binds to Both the C-Terminal 23 Amino Acids of Fibrinogen αC Domain and Factor XIII: Insight into the Mechanism of LigB-Mediated Blockage of Fibrinogen α Chain Cross-Linking.Q36131278
Distinct antibody responses of patients with mild and severe leptospirosis determined by whole proteome microarray analysisQ36264843
LigB subunit vaccine confers sterile immunity against challenge in the hamster model of leptospirosis.Q36310414
Structure-based antigen design: a strategy for next generation vaccinesQ37314536
Fibronectin binds to and induces conformational change in a disordered region of leptospiral immunoglobulin-like protein B.Q37358146
A Universal Vaccine against Leptospirosis: Are We Going in the Right Direction?Q37690431
Immunoglobulin domains in Escherichia coli and other enterobacteria: from pathogenesis to applications in antibody technologiesQ38020872
Leptospiral extracellular matrix adhesins as mediators of pathogen-host interactionsQ38167377
Vaccines against leptospirosisQ38267257
Immunogenicity and protective efficacy of recombinant Leptospira immunoglobulin-like protein B (rLigB) in a hamster challenge modelQ40019697
Repeated domains of leptospira immunoglobulin-like proteins interact with elastin and tropoelastinQ41811666
Immunoprotection of recombinant leptospiral immunoglobulin-like protein A against Leptospira interrogans serovar Pomona infectionQ42118872
BioXTAS RAW: improvements to a free open-source program for small-angle X-ray scattering data reduction and analysisQ42172438
Analysis Tool Web Services from the EMBL-EBI.Q42265365
Evaluation of novel fusion proteins derived from extracellular matrix binding domains of LigB as vaccine candidates against leptospirosis in a hamster modelQ43229732
Leptospira immunoglobulin-like protein A variable region (LigAvar) incorporated in liposomes and PLGA microspheres produces a robust immune response correlating to protective immunityQ44959008
Detection of pathogenic leptospires by real-time quantitative PCR.Q45182868
P407language of work or nameEnglishQ1860
P921main subjectvaccine engineeringQ14861085
P577publication date2017-12-06
P1433published ineLifeQ2000008
P1476titleExtended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design
P478volume6

Reverse relations

Q48208489Chimeras could help in the fight against leptospirosis.cites workP2860

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