The temporal dynamics of plasma fractalkine levels in ischemic stroke: association with clinical severity and outcome

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The temporal dynamics of plasma fractalkine levels in ischemic stroke: association with clinical severity and outcome is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1026743670
P356DOI10.1186/1742-2094-11-74
P932PMC publication ID4022085
P698PubMed publication ID24722201
P5875ResearchGate publication ID261603823

P50authorGerrit M. GrosseQ86120943
P2093author name stringHans Worthmann
Karin Weissenborn
Ralf Lichtinghagen
Henning Pflugrad
Meike Dirks
Ramona Schuppner
Anita B Tryc
P2860cites workClassification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke TreatmentQ22306370
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesionQ24300435
Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survivalQ24676224
CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin.Q24814510
Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microgliaQ28140314
A new class of membrane-bound chemokine with a CX3C motifQ28303204
Control of microglial neurotoxicity by the fractalkine receptorQ28513748
Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activationQ28564261
Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microgliaQ28573077
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functionsQ29615381
Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic strokeQ29619330
Monocytes: protagonists of infarct inflammation and repair after myocardial infarctionQ33942337
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.Q34254575
Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1.Q34391705
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.Q34576624
Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesisQ34828549
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaquesQ35250952
Higher plasma fractalkine is associated with better 6-month outcome from ischemic stroke.Q36195292
Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesisQ36660105
Leukocyte infiltration in experimental strokeQ37367461
The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcomeQ39871785
Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trialQ39914319
A role for spleen monocytes in post-ischemic brain inflammation and injuryQ41646625
Monocyte subtypes predict clinical course and prognosis in human strokeQ44698655
CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodentsQ45325019
Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?Q47895908
Production and neuroprotective functions of fractalkine in the central nervous systemQ48258224
Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury.Q48627196
Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.Q48715061
Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse.Q49160789
Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice.Q52549466
Mild neurological symptoms despite middle cerebral artery occlusion.Q53634128
Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis.Q54573513
Fractalkine is an independent predictor of mortality in patients with advanced heart failureQ58071078
The chemokine fractalkine inhibits Fas-mediated cell death of brain microgliaQ73910771
Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular diseaseQ78594580
P921main subjecttemporal dynamicsQ124178693
P304page(s)74
P577publication date2014-04-10
P1433published inJournal of NeuroinflammationQ15716679
P1476titleThe temporal dynamics of plasma fractalkine levels in ischemic stroke: association with clinical severity and outcome
P478volume11

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cites work (P2860)
Q104473891Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
Q47805638Fractalkine in obstructive sleep apnea patients
Q38530348Fractalkine in the nervous system: neuroprotective or neurotoxic molecule?
Q38400503Modulation of platelet and monocyte function by the chemokine fractalkine (CX3 CL1) in cardiovascular disease
Q36846847Monocyte Subsets and Related Chemokines in Carotid Artery Stenosis and Ischemic Stroke
Q64256559Overexpression of CX3CR1 in Adipose-Derived Stem Cells Promotes Cell Migration and Functional Recovery After Experimental Intracerebral Hemorrhage

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