Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1.

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Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1. is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...743572S
P356DOI10.1371/JOURNAL.PONE.0043572
P932PMC publication ID3423360
P698PubMed publication ID22916279
P5875ResearchGate publication ID230723548

P50authorSteffen MassbergQ91105776
Jaroslav PelisekQ91714534
Johann BauersachsQ21190988
P2093author name stringChristian Schulz
Andreas Schäfer
Michael Lorenz
Marie-Luise von Brühl
Paul F Bray
Moritz Stolla
Anca Tirniceriu
Peter Heider
Verena Barocke
Alexander Steinhart
P2860cites workTransmembrane chemokines: versatile 'special agents' in vascular inflammation.Q53555496
Human fractalkine mediates leukocyte adhesion but not capture under physiological shear conditions; a mechanism for selective monocyte recruitment.Q54650911
Linked Chromosome 16q13 Chemokines, Macrophage-Derived Chemokine, Fractalkine, and Thymus- and Activation-Regulated Chemokine, Are Expressed in Human Atherosclerotic LesionsQ59704063
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart AssociationQ72415283
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial treeQ72689998
A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejectionQ73209237
The chemokine CX3CL1 regulates NK cell activity in vivoQ75212039
Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular diseaseQ78594580
Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1)Q79214234
Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagationQ80388691
Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectorisQ82282569
Pathology of the vulnerable plaqueQ83187650
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesionQ24311291
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and plateletsQ28195974
Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery diseaseQ28206251
A new class of membrane-bound chemokine with a CX3C motifQ28303204
Monitoring of blood vessels and tissues by a population of monocytes with patrolling behaviorQ29616447
Macrophages in the pathogenesis of atherosclerosisQ29617765
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertionQ29618089
Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependentQ30440410
CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wallQ30444644
Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissueQ30978459
Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic rootQ33580505
Intracellular and surface distribution of monocyte tissue factor: application to intersubject variabilityQ34469955
Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesisQ34828549
Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regressionQ34876397
Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humansQ34912596
Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arraysQ35103313
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaquesQ35250952
Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosisQ35554610
In vivo structure/function and expression analysis of the CX3C chemokine fractalkineQ35865080
Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivoQ36238074
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivoQ36370457
Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flowQ36404237
EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wallQ39592493
A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.Q40467498
Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1.Q40797648
An evaluation of methods for imaging and quantifying coronary and carotid lumen stenosis and atherosclerosis.Q40881431
Characterization and functional properties of tumor cell lines in accessory cell replacement assays.Q41462147
A critical role of platelet adhesion in the initiation of atherosclerotic lesion formationQ41824616
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6Q42136332
Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosisQ43726338
Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromesQ44310088
Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivoQ45764285
Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, is elevated in coronary artery disease and is reduced during statin therapyQ46191844
Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb.Q46652724
Overexpression of CXCL16 promotes a vulnerable plaque phenotype in Apolipoprotein E-Knockout MiceQ50550915
An engineered CX3CR1 antagonist endowed with anti-inflammatory activity.Q51778397
Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets.Q51795566
Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice.Q52549466
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectatherosclerosisQ12252367
P304page(s)e43572
P577publication date2012-08-20
P1433published inPLOS OneQ564954
P1476titleFractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1.
P478volume7

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cites work (P2860)
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