Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex.

scientific article

Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex. is …
instance of (P31):
scholarly articleQ13442814

External links are
P932PMC publication ID104457
P698PubMed publication ID9971795

P2093author name stringH Liu
H Xiao
X Wu
J C Kappes
G V Kalpana
V Prasad
J A Conway
E Hehl
P2860cites workBinding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5Q24336208
The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cellsQ24564509
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and compositionQ24673418
Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferasesQ27730298
HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integraseQ28291170
HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitroQ28303975
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN proteinQ28646798
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infectionQ28646834
Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase geneQ29615351
Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and BQ29618922
Functional RT and IN incorporated into HIV-1 particles independently of the Gag/Pol precursor proteinQ33887338
Complementation of integrase function in HIV-1 virions.Q33887343
Retroviral DNA integration: Structure of an integration intermediateQ34177650
Functional association of cyclophilin A with HIV-1 virionsQ34326356
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptaseQ34577497
Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cellsQ35829884
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replicationQ35838477
Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx.Q35839628
Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cellQ35840793
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesisQ35845204
The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures.Q35851966
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection.Q35854265
Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particlesQ35860937
Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcriptionQ35861172
Expression of human immunodeficiency virus type 1 reverse transcriptase in trans during virion release and after infectionQ35861729
Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding siteQ35865776
Characterization of human immunodeficiency virus type 1 Vif particle incorporationQ35868144
Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral proteaseQ35870149
Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.Q35882489
Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self-priming from minus-strand strong-stop DNA.Q35888060
Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein.Q35895836
Binding and kinetic properties of HIV-1 reverse transcriptase markedly differ during initiation and elongation of reverse transcription.Q35917913
Genetic analysis of the human immunodeficiency virus type 1 integrase protein.Q36629409
Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cellsQ36651389
Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1Q36654022
Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex.Q36684088
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitroQ36684957
Truncation of the human immunodeficiency virus type 1 transmembrane glycoprotein cytoplasmic domain blocks virus infectivityQ36685270
Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposasesQ36815395
Murine leukemia virus pol gene products: analysis with antisera generated against reverse transcriptase and endonuclease fusion proteins expressed in Escherichia coli.Q36883944
Mutational analysis of the integrase protein of human immunodeficiency virus type 2Q37245763
Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domainQ38290032
Specific incorporation of cyclophilin A into HIV-1 virionsQ38302257
Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations.Q38322937
Tat is required for efficient HIV-1 reverse transcriptionQ38347693
Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).Q38362410
Human T-cell leukemia virus type 1 reverse transcriptase (RT) originates from the pro and pol open reading frames and requires the presence of RT-RNase H (RH) and RT-RH-integrase proteins for its activity.Q39579463
Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replicationQ39873244
Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.Q39880513
The retroviral enzymesQ40394916
The human immunodeficiency virus integrase proteinQ40721717
Two bases are deleted from the termini of HIV-1 linear DNA during integrative recombinationQ44042137
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitroQ44696814
Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation.Q45770989
Subunit-selective mutagenesis of Glu-89 residue in human immunodeficiency virus reverse transcriptase. Contribution of p66 and p51 subunits to nucleoside analog sensitivity, divalent cation preference, and steady state kinetic properties.Q45789871
Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in vitroQ54677992
Initiation of reverse transcription of HIV-1: secondary structure of the HIV-1 RNA/tRNA(3Lys) (template/primer)Q72134543
P433issue3
P304page(s)2126-2135
P577publication date1999-03-01
P1433published inJournal of VirologyQ1251128
P1476titleHuman immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex
P478volume73

Reverse relations

cites work (P2860)
Q34249167A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase
Q37780981A new functional role of HIV-1 integrase during uncoating of the viral core
Q24815183A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles
Q28483813A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication
Q35046515Allosteric inhibitor development targeting HIV-1 integrase
Q34059119Altered viral fitness and drug susceptibility in HIV-1 carrying mutations that confer resistance to nonnucleoside reverse transcriptase and integrase strand transfer inhibitors
Q33935269Analysis of human immunodeficiency virus type 1 reverse transcriptase subunit structure/function in the context of infectious virions and human target cells
Q33780519Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation
Q30885857Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 Is critical for HIV-1 infection
Q92675301Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase
Q39604854Biochemical analyses of the interactions between human immunodeficiency virus type 1 Vpr and p6(Gag).
Q30157084Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.
Q64106198Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
Q36169613Characterization of HIV-1 integrase N-terminal mutant viruses
Q40275247Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication
Q34163065Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding
Q39915711Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication
Q24814060Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import
Q38499684Cooperation between reverse transcriptase and integrase during reverse transcription and formation of the preintegrative complex of Ty1.
Q41841102Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus
Q37512925Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase
Q39825383Cross-packaging of genetically distinct mouse and primate retroviral RNAs
Q40551545Cross-packaging of human immunodeficiency virus type 1 vector RNA by spleen necrosis virus proteins: construction of a new generation of spleen necrosis virus-derived retroviral vectors
Q36571812Drug Susceptibility and Viral Fitness of HIV-1 with Integrase Strand Transfer Inhibitor Resistance Substitution Q148R or N155H in Combination with Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Resistance Substitutions
Q37333915Functional analysis of N-terminal residues of ty1 integrase
Q35826158Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages
Q26746070HIV Genome-Wide Protein Associations: a Review of 30 Years of Research
Q38124090HIV integrase inhibitors: 20-year landmark and challenges
Q28538038HIV-1 Nef inhibits Protease activity and its absence alters protein content of mature viral particles
Q37689513HIV-1 Vpr-a still "enigmatic multitasker".
Q38380688HIV-1 integrase multimerization as a therapeutic target
Q35069785HIV-1 replication in cell lines harboring INI1/hSNF5 mutations.
Q27023387HIV-1 reverse transcription
Q37430491HIV-1-associated PKA acts as a cofactor for genome reverse transcription
Q33845811Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells
Q35076592Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag.
Q33838354Human immunodeficiency virus type 1 central DNA flap: dynamic terminal product of plus-strand displacement dna synthesis catalyzed by reverse transcriptase assisted by nucleocapsid protein
Q37004198INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo
Q42186812Identification of a novel human immunodeficiency virus type 1 integrase interactor, Gemin2, that facilitates efficient viral cDNA synthesis in vivo
Q37134432Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase
Q35063298Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect
Q37320835In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles
Q35857486Incorporation of human immunodeficiency virus type 1 reverse transcriptase into virus-like particles
Q58751688Induction of HIF-1α by HIV-1 Infection in CD4 T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation
Q43000887Inhibition of the integrases of human immunodeficiency viruses type 1 and type 2 by reverse transcriptases
Q28359887Inhibitors of human immunodeficiency virus type 1 reverse transcriptase target distinct phases of early reverse transcription
Q37353201Integrase and integration: biochemical activities of HIV-1 integrase
Q37232867Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1
Q33812392Integrase-lexA fusion proteins incorporated into human immunodeficiency virus type 1 that contains a catalytically inactive integrase gene are functional to mediate integration
Q36281118Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication
Q40814997Interaction between human immunodeficiency virus type 1 reverse transcriptase and integrase proteins
Q36098878Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription
Q33849672Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells
Q92992903Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition
Q26795766Multifunctional facets of retrovirus integrase
Q37574479Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors
Q41533374Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import
Q36538644Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
Q33911895Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer
Q27678745New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
Q38081866Next-generation integrase inhibitors : where to after raltegravir?
Q34226132Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development
Q35942573Non-POU Domain-Containing Octamer-Binding Protein Negatively Regulates HIV-1 Infection in CD4(+) T Cells
Q64087409Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication
Q37083719Posttranslational modifications of HIV-1 integrase by various cellular proteins during viral replication
Q33816738Proteolytic activity, the carboxy terminus of Gag, and the primer binding site are not required for Pol incorporation into foamy virus particles
Q33463283Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication
Q35607763Reduced viral fitness and lack of cross-class resistance with integrase strand transfer inhibitor and nucleoside reverse transcriptase inhibitor resistance mutations
Q36473812Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in IN augment DNA synthesis.
Q30341397Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.
Q28596842Retroviral DNA Integration
Q35249277Retroviral DNA Transposition: Themes and Variations
Q28073156Retroviral Integrase: Then and Now
Q37722585Retroviral reverse transcriptases
Q33257614Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteins
Q35260021Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription.
Q51003294Reverse Transcription of Retroviruses and LTR Retrotransposons.
Q33826918Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core
Q41827820Role of integrase in reverse transcription of the Saccharomyces cerevisiae retrotransposon Ty1.
Q39582953Sequential deletion of the integrase (Gag-Pol) carboxyl terminus reveals distinct phenotypic classes of defective HIV-1.
Q35956555Signals in APOBEC3F N-terminal and C-terminal deaminase domains each contribute to encapsidation in HIV-1 virions and are both required for HIV-1 restriction
Q24307975Specificity of interaction of INI1/hSNF5 with retroviral integrases and its functional significance
Q31115387Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex
Q30009248Structural dynamics of native and V260E mutant C-terminal domain of HIV-1 integrase
Q40883677Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents
Q34339757Subcellular localization and integration activities of rous sarcoma virus reverse transcriptase
Q34438247Subunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo.
Q33821401Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1.
Q39545432The 156KELK159 tetrapeptide of HIV-1 integrase is critical for lentiviral gene integration
Q47735179The HIV-1 Nef protein enhances the affinity of reverse transcriptase for RNA in vitro.
Q37027897The N-end rule and retroviral infection: no effect on integrase
Q33864450The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro
Q21245211The Vpr protein from HIV-1: distinct roles along the viral life cycle
Q35215018The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome
Q39402465The cellular antiviral protein APOBEC3G interacts with HIV-1 reverse transcriptase and inhibits its function during viral replication
Q37110732The chromodomain of Tf1 integrase promotes binding to cDNA and mediates target site selection
Q42932779The combined anti-HIV-1 activities of emtricitabine and tenofovir plus the integrase inhibitor elvitegravir or raltegravir show high levels of synergy in vitro
Q34999802The conformation of the mature dimeric human immunodeficiency virus type 1 RNA genome requires packaging of pol protein.
Q33676449The foamy virus genome remains unintegrated in the nuclei of G1/S phase-arrested cells, and integrase is critical for preintegration complex transport into the nucleus
Q39592447The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.
Q35023991The self primer of the long terminal repeat retrotransposon Tf1 is not removed during reverse transcription
Q41860319Transcription factor YY1 interacts with retroviral integrases and facilitates integration of moloney murine leukemia virus cDNA into the host chromosomes
Q34332190Ty3 integrase is required for initiation of reverse transcription
Q35962942von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step

Search more.