| scholarly article | Q13442814 |
| P2093 | author name string | R Craigie | |
| D R Davies | |||
| A Engelman | |||
| T M Jenkins | |||
| F Dyda | |||
| A B Hickman | |||
| P433 | issue | 5193 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | HIV | Q15787 |
| crystal structure | Q895901 | ||
| P304 | page(s) | 1981-6 | |
| P577 | publication date | 1994-12-23 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases | |
| P478 | volume | 266 |
| Q37095708 | 3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H. |
| Q34770674 | 3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase |
| Q27679066 | 3′-Processing and strand transfer catalysed by retroviral integrasein crystallo |
| Q35941741 | A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes |
| Q27728086 | A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain |
| Q27653369 | A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75 |
| Q89729176 | A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies |
| Q34249167 | A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase |
| Q40969466 | A high-throughput assay for Tn5 Tnp-induced DNA cleavage |
| Q33887922 | A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration |
| Q33785484 | A map of interactions between the proteins of a retrotransposon |
| Q73442728 | A metal-induced conformational change and activation of HIV-1 integrase |
| Q38269549 | A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases |
| Q39882032 | A mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site |
| Q27683994 | A new class of multimerization selective inhibitors of HIV-1 integrase |
| Q37780981 | A new functional role of HIV-1 integrase during uncoating of the viral core |
| Q35728785 | A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity |
| Q27676654 | A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding |
| Q42847218 | A simple in vivo assay for increased protein solubility |
| Q39036396 | A supramolecular assembly mediates lentiviral DNA integration |
| Q26851891 | A survey of protein structures from archaeal viruses |
| Q36766768 | A targeted DNA substrate mechanism for the inhibition of HIV-1 integrase by inhibitors with antiretroviral activity |
| Q45423719 | A three-dimensional model of the human immunodeficiency virus type 1 integration complex |
| Q39605911 | A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors |
| Q46245422 | Activation/attenuation model for RNase H. A one-metal mechanism with second-metal inhibition. |
| Q40065675 | Adaptive HIV-1 evolutionary trajectories are constrained by protein stability |
| Q27677515 | Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation |
| Q33488152 | An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule |
| Q34743380 | An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA. |
| Q33396954 | An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF. |
| Q54787261 | Analysis of the DDE motif in the Mutator superfamily. |
| Q34025733 | Anomalous diffraction in crystallographic phase evaluation |
| Q64082927 | Anti-HIV-1 integrase potency of methylgallate from Alchornea cordifolia using in vitro and in silico approaches |
| Q30432379 | Application of protein engineering to enhance crystallizability and improve crystal properties |
| Q42551671 | Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors |
| Q41101007 | Approaches to crystallizing P450s |
| Q30500118 | Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking |
| Q38296937 | Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase |
| Q37009146 | Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions |
| Q33237569 | Bacterial repetitive extragenic palindromic sequences are DNA targets for Insertion Sequence elements |
| Q35000484 | Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaks |
| Q34372481 | Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase |
| Q27740341 | Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity |
| Q96607405 | Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor |
| Q42265700 | Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase |
| Q37518408 | Biochemical and random mutagenesis analysis of the region carrying the catalytic E152 amino acid of HIV-1 integrase |
| Q34049220 | Biochemical characteristics of functional domains using feline foamy virus integrase mutants |
| Q42245267 | Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations |
| Q24656978 | Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137) |
| Q41610600 | Brownian and essential dynamics studies of the HIV-1 integrase catalytic domain |
| Q36400167 | C-Terminal Domain of Integrase Binds between the Two Active Sites |
| Q36175931 | CX, DPX, and PCW: Web Servers for the Visualization of Interior and Protruding Regions of Protein Structures in 3D and 1D. |
| Q77654970 | Candidate antiretroviral agents for use in postexposure prophylaxis |
| Q27630838 | Catalytic center of an archaeal type 2 ribonuclease H as revealed by X-ray crystallographic and mutational analyses |
| Q34181199 | Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues |
| Q37208652 | Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs |
| Q54435795 | Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors. |
| Q39596582 | Charge-to-alanine mutagenesis of the adeno-associated virus type 2 Rep78/68 proteins yields temperature-sensitive and magnesium-dependent variants |
| Q37616459 | Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses |
| Q40275247 | Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication |
| Q42680313 | Cloning and sequencing of ISC1041 from the archaeon Sulfolobus solfataricus MT-4, a new member of the IS30 family of insertion elements |
| Q41917274 | Combining site-specific mutagenesis and seeding as a strategy to crystallize 'difficult' proteins: the case of Staphylococcus aureus thioredoxin. |
| Q34190096 | Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/M154I catalytic domain. |
| Q51111063 | Complete backbone and DENQ side chain NMR assignments in proteins from a single experiment: implications to structure-function studies. |
| Q24801650 | Comprehensive analysis of pseudogenes in prokaryotes: widespread gene decay and failure of putative horizontally transferred genes |
| Q42279698 | Computational design of a full-length model of HIV-1 integrase: modeling of new inhibitors and comparison of their calculated binding energies with those previously studied |
| Q42119068 | Computational screening of inhibitors for HIV-1 integrase using a receptor based pharmacophore model |
| Q43853916 | Computer aided study of ligand binding with catalytic domain of Avian sarcoma virus integrase and its ligand binding loops |
| Q36145611 | Computer tools in the discovery of HIV-1 integrase inhibitors |
| Q39873244 | Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication |
| Q39915711 | Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication |
| Q35861832 | Coordinated disintegration reactions mediated by Moloney murine leukemia virus integrase |
| Q37512925 | Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase |
| Q33887759 | Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking |
| Q39735673 | Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis |
| Q33900890 | Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome |
| Q27729817 | Crystal structure of Thermus aquaticus DNA polymerase |
| Q27666455 | Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods |
| Q62673097 | Crystal structure of avian sarcoma virus integrase with bound essential cations |
| Q27625292 | Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding |
| Q27660224 | Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site |
| Q62673107 | Crystal structure of the catalytic domain of avian sarcoma virus integrase |
| Q35024135 | Crystal structure of the moloney murine leukemia virus RNase H domain |
| Q41978633 | Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA. |
| Q27666444 | Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNA |
| Q33671188 | Crystal structures of catalytic core domains of retroviral integrases and role of divalent cations in enzymatic activity. |
| Q41206718 | Crystallization of biological macromolecules for X-ray diffraction studies |
| Q34124977 | DDE transposases: Structural similarity and diversity |
| Q38836237 | DNA Transposition at Work |
| Q92069639 | DNA bending in the synaptic complex in V(D)J recombination: turning an ancestral transpososome upside down |
| Q44197679 | DNA branch nuclease activity of vaccinia A22 resolvase |
| Q33852325 | DNA shuffling as a tool for protein crystallization |
| Q92675146 | Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure |
| Q39140673 | Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors |
| Q40117943 | Design, synthesis, and antiviral evaluation of some 3'-carboxymethyl-3'-deoxyadenosine derivatives |
| Q28366147 | Determinants for hairpin formation in Tn10 transposition |
| Q34823306 | Determination of the structures of symmetric protein oligomers from NMR chemical shifts and residual dipolar couplings |
| Q28379316 | Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase |
| Q71726932 | Different enzymes with similar structures involved in Mg(2+)-mediated polynucleotidyl transfer |
| Q42648200 | Differential multimerization of Moloney murine leukemia virus integrase purified under nondenaturing conditions. |
| Q42017701 | Differential sensitivities of retroviruses to integrase strand transfer inhibitors |
| Q34067223 | Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes |
| Q34731189 | Directed DNA shuffling of retrovirus and retrotransposon integrase protein domains |
| Q27640298 | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis |
| Q35853164 | Directed integration of viral DNA mediated by fusion proteins consisting of human immunodeficiency virus type 1 integrase and Escherichia coli LexA protein |
| Q27684242 | Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1 |
| Q43621555 | Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase |
| Q30175843 | Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis |
| Q34228616 | Division of labor within human immunodeficiency virus integrase complexes: determinants of catalysis and target DNA capture |
| Q36968390 | Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein |
| Q39580790 | Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzyme-substrate interactions |
| Q39952961 | Effects of varying the spacing within the D,D-35-E motif in the catalytic region of retroviral integrase |
| Q33782371 | Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 integrase. |
| Q71817898 | Enhanced and coordinated processing of synapsed viral DNA ends by retroviral integrases in vitro |
| Q28379401 | Equivalent inhibition of half-site and full-site retroviral strand transfer reactions by structurally diverse compounds |
| Q40214545 | Evaluation of the functional involvement of human immunodeficiency virus type 1 integrase in nuclear import of viral cDNA during acute infection |
| Q38303645 | Expression of deletion mutants of the hepatitis B virus protein HBx in E. coli and characterization of their RNA binding activities. |
| Q35468454 | FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75. |
| Q34180079 | Facile measurement of 1H–15N residual dipolar couplings in larger perdeuterated proteins |
| Q27735010 | Flexibility in DNA recombination: structure of the lambda integrase catalytic core |
| Q48717960 | Focal contributions to molecular biophysics and structural biology: a personal view. Part III. |
| Q38264756 | Folding and Purification of Insoluble (Inclusion Body) Proteins from Escherichia coli. |
| Q54423617 | Folding and purification of insoluble (inclusion body) proteins from Escherichia coli. |
| Q27666603 | Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 |
| Q34314898 | Fragment-based screening by protein crystallography: successes and pitfalls |
| Q37333915 | Functional analysis of N-terminal residues of ty1 integrase |
| Q27653000 | Functional and structural characterization of the integrase from the prototype foamy virus |
| Q74473323 | Functional characterization of the Tn5 transposase by limited proteolysis |
| Q39551623 | Functional interactions of the HHCC domain of moloney murine leukemia virus integrase revealed by nonoverlapping complementation and zinc-dependent dimerization |
| Q45730026 | Functional oligomeric state of avian sarcoma virus integrase |
| Q33782016 | Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase |
| Q42091632 | Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase |
| Q42681806 | Gypsy-like retrotransposons are widespread in the plant kingdom. |
| Q36065855 | HIV DNA integration |
| Q40177747 | HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination |
| Q36842230 | HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent |
| Q30175416 | HIV integrase structure and function. |
| Q34247770 | HIV integrase, a brief overview from chemistry to therapeutics |
| Q30407372 | HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme. |
| Q33814351 | HIV-1 IN inhibitors: 2010 update and perspectives |
| Q41813484 | HIV-1 Integrase Strand Transfer Inhibitors: Novel Insights into their Mechanism of Action. |
| Q37945176 | HIV-1 Integrase-DNA Recognition Mechanisms |
| Q24642513 | HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway |
| Q44134677 | HIV-1 infection requires a functional integrase NLS. |
| Q38348637 | HIV-1 integrase and virus and cell DNAs: complex formation and perturbation by inhibitors of integration |
| Q37957767 | HIV-1 integrase inhibitors: a review of their chemical development. |
| Q34050694 | HIV-1 integrase inhibitors: past, present, and future |
| Q37034614 | HIV-1 integrase inhibitors: update and perspectives |
| Q31059280 | HIV-1 integrase interacts with yeast microtubule-associated proteins |
| Q38380688 | HIV-1 integrase multimerization as a therapeutic target |
| Q34257536 | HIV-1 integrase: the next target for AIDS therapy? |
| Q39332246 | Hepatitis B virus genetic diversity has minimal impact on sensitivity of the viral ribonuclease H to inhibitors. |
| Q38236778 | Heteromeric transposase elements: generators of genomic islands across diverse bacteria. |
| Q35076592 | Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag. |
| Q35854265 | Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. |
| Q33653264 | Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex. |
| Q28343322 | Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes |
| Q40666094 | Human immunodeficiency virus type-1 integrase containing a glycine to serine mutation at position 140 is attenuated for catalysis and resistant to integrase inhibitors |
| Q38307116 | Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets. |
| Q92923587 | Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach |
| Q28378737 | Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library |
| Q28379456 | Identification of a nucleotide binding site in HIV-1 integrase |
| Q33202469 | Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry |
| Q39591194 | Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells. |
| Q34058459 | Identification of four acidic amino acids that constitute the catalytic center of the RuvC Holliday junction resolvase. |
| Q44408694 | Identification of potential HIV-1 integrase strand transfer inhibitors: in silico virtual screening and QM/MM docking studies |
| Q43230400 | Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis |
| Q52081212 | Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. |
| Q45262143 | Identifying amino acid residues that contribute to the cellular-DNA binding site on retroviral integrase |
| Q39642519 | Implication of a central cysteine residue and the HHCC domain of Moloney murine leukemia virus integrase protein in functional multimerization |
| Q35152980 | Improvement of the crystallizability and expression of an RNA crystallization chaperone |
| Q34785977 | In search of authentic inhibitors of HIV-1 integration |
| Q45959420 | Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors. |
| Q99635824 | Influence of the amino-terminal sequence on the structure and function of HIV integrase |
| Q39352071 | Inhibiting the HIV integration process: past, present, and the future. |
| Q40224642 | Inhibition of hepatitis B virus replication by N-hydroxyisoquinolinediones and related polyoxygenated heterocycles. |
| Q35864113 | Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions |
| Q40666856 | Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones. |
| Q33929260 | Inhibition of the integrase of human immunodeficiency virus (HIV) type 1 by anti-HIV plant proteins MAP30 and GAP31 |
| Q34338157 | Inhibitor design by wrapping packing defects in HIV-1 proteins |
| Q28378926 | Inhibitors of HIV-1 replication [corrected; erratum to be published] that inhibit HIV integrase |
| Q34597590 | Inhibitors of nucleotidyltransferase superfamily enzymes suppress herpes simplex virus replication |
| Q35753670 | Insertion Sequence IS26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition |
| Q40507833 | Integrase illuminated |
| Q48066731 | Integrase variability and susceptibility to HIV integrase inhibitors: impact of subtypes, antiretroviral experience and duration of HIV infection |
| Q37081043 | Integrase, LEDGF/p75 and HIV replication |
| Q35023166 | Integrating prokaryotes and eukaryotes: DNA transposases in light of structure. |
| Q45888150 | Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop |
| Q24295223 | Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2) |
| Q38524164 | Interactions of HIV-1 proteins as targets for developing anti-HIV-1 peptides. |
| Q44366616 | Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization |
| Q39877349 | Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase. |
| Q40429974 | Isolation and characterization of Tn7 transposase gain-of-function mutants: a model for transposase activation |
| Q35577172 | Key determinants of target DNA recognition by retroviral intasomes |
| Q34190126 | Large-scale conformational dynamics of the HIV-1 integrase core domain and its catalytic loop mutants |
| Q39879606 | Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ. |
| Q38304436 | Mapping DNA-binding sites of HIV-1 integrase by protein footprinting |
| Q73399668 | Mapping target site selection for the non-specific nuclease activities of retroviral integrase |
| Q33782240 | Mapping viral DNA specificity to the central region of integrase by using functional human immunodeficiency virus type 1/visna virus chimeric proteins |
| Q40477773 | Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor. |
| Q33385047 | Mass spectrometry-based footprinting of protein-protein interactions |
| Q30398335 | Measuring rapid hydrogen exchange in the homodimeric 36 kDa HIV-1 integrase catalytic core domain |
| Q27649763 | Mechanism of IS200/IS605 Family DNA Transposases: Activation and Transposon-Directed Target Site Selection |
| Q41962136 | Mechanism of Mos1 transposition: insights from structural analysis |
| Q38312462 | Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in Vitro |
| Q38536147 | Mechanisms of DNA Transposition |
| Q39249012 | Mechanisms of LTR-Retroelement Transposition: Lessons from Drosophila melanogaster |
| Q34437364 | Metal binding by the D,DX35E motif of human immunodeficiency virus type 1 integrase: selective rescue of Cys substitutions by Mn2+ in vitro |
| Q35928001 | Metal binding properties and secondary structure of the zinc-binding domain of Nup475. |
| Q64910935 | Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design. |
| Q35260416 | Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors |
| Q73006626 | Modeling the late steps in HIV-1 retroviral integrase-catalyzed DNA integration |
| Q34976859 | Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules |
| Q27684349 | Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease |
| Q37468745 | Molecular Interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration |
| Q52565366 | Molecular architecture of a eukaryotic DNA transposase. |
| Q35666439 | Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity |
| Q34180538 | Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistance |
| Q34170581 | Molecular dynamics studies on the HIV-1 integrase catalytic domain |
| Q34063962 | Molecular genetics and target site specificity of retroviral integration |
| Q40868886 | Molecular mechanisms in retrovirus DNA integration |
| Q27735990 | Molecular organization in site-specific recombination: the catalytic domain of bacteriophage HP1 integrase at 2.7 A resolution |
| Q71032193 | Mu transpositional recombination: donor DNA cleavage and strand transfer in trans by the Mu transposase |
| Q92992903 | Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition |
| Q45790359 | Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase |
| Q37574479 | Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors |
| Q27678141 | Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors |
| Q45749105 | Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome |
| Q43982347 | Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events |
| Q76368269 | Mutational analyses of the core domain of Avian Leukemia and Sarcoma Viruses integrase: critical residues for concerted integration and multimerization |
| Q39578393 | Mutational scan of the human immunodeficiency virus type 2 integrase protein |
| Q40178054 | Mutations in the catalytic core or the C-terminus of murine leukemia virus (MLV) integrase disrupt virion infectivity and exert diverse effects on reverse transcription |
| Q43837693 | N-Terminal domain of HTLV-I integrase. Complexation and conformational studies of the zinc finger |
| Q28751928 | New superfamilies of eukaryotic DNA transposons and their internal divisions |
| Q64250462 | Non-Cryogenic Structure and Dynamics of HIV-1 Integrase Catalytic Core Domain by X-ray Free-Electron Lasers |
| Q34226132 | Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development |
| Q27003960 | Novel therapeutic strategies targeting HIV integrase |
| Q33671175 | Nuclear import of human immunodeficiency virus type-1 preintegration complexes. |
| Q39035944 | Nuclear landscape of HIV-1 infection and integration |
| Q37790458 | Nucleases: diversity of structure, function and mechanism. |
| Q59358804 | Nucleoprotein Intermediates in HIV-1 DNA Integration: Structure and Function of HIV-1 Intasomes |
| Q27660109 | ORF157 from the Archaeal Virus Acidianus Filamentous Virus 1 Defines a New Class of Nuclease |
| Q39594236 | Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integrase |
| Q30368988 | Overview of protein structural and functional folds. |
| Q33459180 | Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity |
| Q41884572 | Patterns of resistance development with integrase inhibitors in HIV. |
| Q35222265 | Patterns of sequence conservation at termini of long terminal repeat (LTR) retrotransposons and DNA transposons in the human genome: lessons from phage Mu. |
| Q33213216 | Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase |
| Q27652151 | Phosphate coordination and movement of DNA in the Tn5 synaptic complex: role of the (R)YREK motif |
| Q37353786 | Piecing together the structure of retroviral integrase, an important target in AIDS therapy |
| Q36944236 | Potentials of phenolic molecules of natural origin and their derivatives as anti-HIV agents |
| Q24791572 | Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase |
| Q27860869 | Preparation of selenomethionyl proteins for phase determination |
| Q34842642 | Presence of a characteristic D-D-E motif in IS1 transposase |
| Q37144775 | Principles of macromolecular X-ray crystallography |
| Q54484307 | Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration. |
| Q40405021 | Progress in anti-HIV structure-based drug design |
| Q37379719 | Protein Crystal Engineering of YpAC-IV using the Strategy of Excess Charge Reduction |
| Q30384774 | Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures. |
| Q39671295 | Purification and enzymatic characterization of the hepatitis B virus ribonuclease H, a new target for antiviral inhibitors |
| Q35950702 | Purification, crystallization and preliminary crystallographic analysis of the Hermes transposase |
| Q33968434 | Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination |
| Q36438686 | Rapid experimental SAD phasing and hot-spot identification with halogenated fragments |
| Q27661671 | Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication |
| Q47753998 | Reactivity of selenomethionine--dents in the magic bullet? |
| Q58760446 | Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase |
| Q28372055 | Recognition and inhibition of HIV integrase by a novel dinucleotide |
| Q40516667 | Recombining the structures of HIV integrase, RuvC and RNase H. |
| Q54605929 | Reconstitution of Escherichia coli RNase HI from the N-fragment with High Helicity and the C-fragment with a Disordered Structure |
| Q27628711 | Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase |
| Q59797229 | Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An analysis |
| Q71141599 | Relationships between transposable elements based upon the integrase-transposase domains: is there a common ancestor? |
| Q36208424 | Remodeling protein complexes: insights from the AAA+ unfoldase ClpX and Mu transposase |
| Q33702230 | Resident aliens: the Tc1/mariner superfamily of transposable elements |
| Q34059896 | Resistance to integrase inhibitors |
| Q41925654 | Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing |
| Q28368842 | Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase |
| Q45745530 | Retrotransposon BARE-1: expression of encoded proteins and formation of virus-like particles in barley cells |
| Q28596842 | Retroviral DNA Integration |
| Q35249277 | Retroviral DNA Transposition: Themes and Variations |
| Q36314249 | Retroviral DNA integration--mechanism and consequences |
| Q33787076 | Retroviral DNA integration. |
| Q34500837 | Retroviral DNA integration: reaction pathway and critical intermediates |
| Q34668065 | Retroviral Integrase Structure and DNA Recombination Mechanism |
| Q28073156 | Retroviral Integrase: Then and Now |
| Q24629737 | Retroviral intasome assembly and inhibition of DNA strand transfer |
| Q39273807 | Retroviral intasomes arising |
| Q39176798 | Retroviral integrase protein and intasome nucleoprotein complex structures |
| Q34643561 | Retroviral integrase proteins and HIV-1 DNA integration |
| Q34928560 | Retroviral integrase superfamily: the structural perspective |
| Q41029973 | Retroviral integrase, putting the pieces together |
| Q34387887 | Retroviral integrases and their cousins |
| Q79748685 | Retroviral integrases that are improved for processing but impaired for joining |
| Q33257614 | Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteins |
| Q35260021 | Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription. |
| Q35873097 | Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity |
| Q34948257 | Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes |
| Q90737631 | Rigidity and flexibility characteristics of DD[E/D]-transposases Mos1 and Sleeping Beauty |
| Q40900031 | Role of metal ions in catalysis by HIV integrase analyzed using a quantitative PCR disintegration assay |
| Q38296174 | Role of the nonspecific DNA-binding region and alpha helices within the core domain of retroviral integrase in selecting target DNA sites for integration |
| Q34243775 | RuvC protein resolves Holliday junctions via cleavage of the continuous (noncrossover) strands. |
| Q43067258 | Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited |
| Q30584583 | Self-association and domains of interactions of an amphipathic helix peptide inhibitor of HIV-1 integrase assessed by analytical ultracentrifugation and NMR experiments in trifluoroethanol/H(2)O mixtures |
| Q30637784 | Self-association of an amphipathic helix peptide inhibitor of HIV-1 integrase assessed by electro spray ionization mass spectrometry in trifluoroethanol/water mixtures |
| Q33889660 | Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction |
| Q39582953 | Sequential deletion of the integrase (Gag-Pol) carboxyl terminus reveals distinct phenotypic classes of defective HIV-1. |
| Q73469975 | Similarities in the HIV-1 and ASV integrase active sites upon metal cofactor binding |
| Q64388530 | Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity |
| Q35757779 | Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA. |
| Q38292353 | Site-specific photo-cross-linking between lambda integrase and its DNA recombination target |
| Q35658231 | Small-angle X-ray characterization of the nucleoprotein complexes resulting from DNA-induced oligomerization of HIV-1 integrase |
| Q30408688 | Soluble expression, purification and characterization of the full length IS2 Transposase |
| Q33885382 | Solution conformation and dynamics of the HIV-1 integrase core domain |
| Q33887936 | Solution structure of the Mu end DNA-binding ibeta subdomain of phage Mu transposase: modular DNA recognition by two tethered domains. |
| Q27740763 | Solution structure of the N-terminal zinc binding domain of HIV-1 integrase |
| Q73425921 | Solving the cis/trans paradox in the Int family of recombinases |
| Q39581624 | Specific and independent recognition of U3 and U5 att sites by human immunodeficiency virus type 1 integrase in vivo. |
| Q38349833 | Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase {alpha}4 helix |
| Q28369425 | Stability-activity relationships of a family of G-tetrad forming oligonucleotides as potent HIV inhibitors. A basis for anti-HIV drug design |
| Q42269421 | Stabilization of the integrase-DNA complex by Mg2+ ions and prediction of key residues for binding HIV-1 integrase inhibitors. |
| Q41701981 | Stereospecificity of reactions catalyzed by HIV-1 integrase |
| Q38356920 | Strategy to discriminate between high and low affinity bindings of human immunodeficiency virus, type 1 integrase to viral DNA. |
| Q43601530 | Strong nucleic acid binding to the Escherichia coli RNase HI mutant with two arginine residues at the active site |
| Q27681216 | Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir |
| Q92825482 | Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses |
| Q28547968 | Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor |
| Q37083728 | Structural and functional insights into foamy viral integrase |
| Q31115387 | Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex |
| Q30009173 | Structural and sequencing analysis of local target DNA recognition by MLV integrase |
| Q30487128 | Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor |
| Q27316560 | Structural basis for functional tetramerization of lentiviral integrase |
| Q35933084 | Structural basis for retroviral integration into nucleosomes. |
| Q35961942 | Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I. |
| Q34161123 | Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. |
| Q36806748 | Structural biology of retroviral DNA integration |
| Q42570699 | Structural biology: When four become one. |
| Q30175939 | Structural determinants of metal-induced conformational changes in HIV-1 integrase |
| Q35290996 | Structural folds of viral proteins |
| Q35875958 | Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase. |
| Q33924454 | Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers |
| Q27664231 | Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain |
| Q27636829 | Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein |
| Q27620348 | Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design |
| Q27749615 | Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor |
| Q34141071 | Structure-based HIV-1 integrase inhibitor design: a future perspective |
| Q34115746 | Structure-based modeling of the functional HIV-1 intasome and its inhibition |
| Q35882489 | Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase. |
| Q39580599 | Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: critical residues for protein oligomerization and DNA binding |
| Q35876147 | Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases |
| Q33589910 | Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding |
| Q38993322 | Successes and challenges with retroviral enzymes |
| Q36485425 | Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: implications for retroviral assembly mechanisms |
| Q46912327 | Synthetic approaches to nuclease-resistant, nonnatural dinucleotides of anti-HIV integrase interest |
| Q34487877 | Tailed bacteriophages: the order caudovirales |
| Q35050390 | Targeting HIV-1 integrase |
| Q31164008 | Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors |
| Q27677549 | The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors |
| Q36682142 | The DDE recombinases: diverse roles in acquired and innate immunity |
| Q30193156 | The DNA-binding domain of HIV-1 integrase has an SH3-like fold |
| Q36701774 | The GP(Y/F) domain of TF1 integrase multimerizes when present in a fragment, and substitutions in this domain reduce enzymatic activity of the full-length protein |
| Q43750077 | The HIV integrase catalytic core |
| Q33786815 | The HIV-1 integrase α4-helix involved in LTR-DNA recognition is also a highly antigenic peptide element |
| Q37945179 | The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights |
| Q41884057 | The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness |
| Q36581635 | The Mu story: how a maverick phage moved the field forward |
| Q39840417 | The RuvABC proteins and Holliday junction processing in Escherichia coli |
| Q41078625 | The Tn7 transposase is a heteromeric complex in which DNA breakage and joining activities are distributed between different gene products. |
| Q27863698 | The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits |
| Q34069694 | The application of a homologous recombination assay revealed amino acid residues in an LTR-retrotransposon that were critical for integration. |
| Q37491609 | The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA. |
| Q27733364 | The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations |
| Q27734254 | The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant |
| Q40879827 | The core domain of HIV-1 integrase recognizes key features of its DNA substrates |
| Q38065357 | The emerging diversity of transpososome architectures. |
| Q35582561 | The hepatitis B virus ribonuclease H as a drug target |
| Q28485228 | The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes |
| Q71032186 | The interwoven architecture of the Mu transposase couples DNA synapsis to catalysis |
| Q39592447 | The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA. |
| Q36281117 | The molecular biology of HIV integrase |
| Q44439324 | The organization of human leucocyte antigen class I epitopes in HIV genome products: implications for HIV evolution and vaccine design |
| Q35610274 | The outs and ins of transposition: from mu to kangaroo |
| Q35116317 | The protein as a variable in protein crystallization |
| Q57799661 | The role of integration and clonal expansion in HIV infection: live long and prosper |
| Q36291616 | The role of lysine 186 in HIV-1 integrase multimerization |
| Q38361149 | The role of manganese in promoting multimerization and assembly of human immunodeficiency virus type 1 integrase as a catalytically active complex on immobilized long terminal repeat substrates |
| Q40427597 | The science of macromolecular crystallization |
| Q73878403 | The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc |
| Q27617962 | The three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolution |
| Q71859993 | Thermal stability of Escherichia coli ribonuclease HI and its active site mutants in the presence and absence of the Mg2+ ion. Proposal of a novel catalytic role for Glu48 |
| Q27764898 | Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium |
| Q36486586 | Tn552 transposase catalyzes concerted strand transfer in vitro |
| Q34443592 | Tn7: smarter than we thought |
| Q33888644 | Transposase makes critical contacts with, and is stimulated by, single-stranded DNA at the P element termini in vitro |
| Q41011364 | Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system |
| Q52654190 | Transposition of hAT elements links transposable elements and V(D)J recombination. |
| Q95793913 | Treatment of multiwavelength anomalous diffraction data as a special case of multiple isomorphous replacement |
| Q37485954 | True reversal of Mu integration |
| Q39875259 | Ty3 integrase mutants defective in reverse transcription or 3'-end processing of extrachromosomal Ty3 DNA. |
| Q35360391 | Uneven genetic robustness of HIV-1 integrase |
| Q27625490 | Unexpected structural diversity in DNA recombination: the restriction endonuclease connection |
| Q33853157 | Use of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selection |
| Q38250453 | Virtual-screening targeting Human Immunodeficiency Virus type 1 integrase-lens epithelium-derived growth factor/p75 interaction for drug development |
| Q35922636 | Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity |
| Q88661401 | [1] Recent transformations in structural biology |
| Q30047434 | [28] Phase determination from multiwavelength anomalous diffraction measurements |
| Q36570713 | piggyBac can bypass DNA synthesis during cut and paste transposition |
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