| scholarly article | Q13442814 |
| P50 | author | Harold E. Varmus | Q295691 |
| P2093 | author name string | A D Leavitt | |
| G Robles | |||
| N Alesandro | |||
| P2860 | cites work | DNA sequencing with chain-terminating inhibitors | Q22066207 |
| Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5 | Q24336208 | ||
| Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases | Q27730298 | ||
| Rapid and efficient site-specific mutagenesis without phenotypic selection | Q27860628 | ||
| Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity | Q33666234 | ||
| Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae | Q33932483 | ||
| Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex | Q34057841 | ||
| Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase | Q35237118 | ||
| Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells | Q35829884 | ||
| Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication | Q35838477 | ||
| Retroviral integrase domains: DNA binding and the recognition of LTR sequences | Q35914265 | ||
| Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding | Q36243985 | ||
| Genetic analysis of the human immunodeficiency virus type 1 integrase protein. | Q36629409 | ||
| The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. | Q36635228 | ||
| Integrase mutants of human immunodeficiency virus type 1 with a specific defect in integration. | Q36638299 | ||
| Genetic analysis of homomeric interactions of human immunodeficiency virus type 1 integrase using the yeast two-hybrid system | Q36662251 | ||
| Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro | Q36684957 | ||
| Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range | Q36687863 | ||
| Partial reverse transcripts in virions from human immunodeficiency and murine leukemia viruses | Q36700508 | ||
| Viral DNA carried by human immunodeficiency virus type 1 virions | Q36701114 | ||
| Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity. | Q36793180 | ||
| Integration is not necessary for expression of human immunodeficiency virus type 1 protein products | Q36806287 | ||
| Retroviral DNA integrated during infection by an integration-deficient mutant of murine leukemia virus is oligomeric. | Q36888976 | ||
| Mutational analysis of the integrase protein of human immunodeficiency virus type 2 | Q37245763 | ||
| Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA | Q37402258 | ||
| Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes | Q37402708 | ||
| A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration | Q37573656 | ||
| Integration of retroviral DNA. | Q37950645 | ||
| Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations. | Q38322937 | ||
| Localization of DNA binding activity of HIV-1 integrase to the C-terminal half of the protein | Q38330714 | ||
| Substrate specificity of recombinant human immunodeficiency virus integrase protein | Q38333063 | ||
| Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues. | Q40038402 | ||
| Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage | Q40106579 | ||
| The retroviral enzymes | Q40394916 | ||
| Complementation between HIV integrase proteins mutated in different domains | Q40873688 | ||
| Retroviral integration into minichromosomes in vitro | Q41514592 | ||
| Development of techniques to analyse the formation of HIV provirus in primary human macrophages | Q43557911 | ||
| Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro | Q44696814 | ||
| Reversal of Integration and DNA Splicing Mediated by Integrase of Human Immunodeficiency Virus | Q45857942 | ||
| Mapping of immunodominant epitopes of the HIV-1 and HIV-2 integrase proteins by recombinant proteins and synthetic peptides | Q54676491 | ||
| Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase | Q54678868 | ||
| HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer | Q67802014 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 8 | |
| P304 | page(s) | 721-728 | |
| P577 | publication date | 1996-02-01 | |
| P1433 | published in | Journal of Virology | Q1251128 |
| P1476 | title | Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection | |
| P478 | volume | 70 |
| Q33922412 | A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain |
| Q36646385 | A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin |
| Q37780981 | A new functional role of HIV-1 integrase during uncoating of the viral core |
| Q34469817 | A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria |
| Q24815183 | A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles |
| Q40249131 | A phenotypic recessive, post-entry block in rabbit cells that results in aberrant trafficking of HIV-1. |
| Q37548504 | A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity. |
| Q40159851 | Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells |
| Q39227747 | Assessment of Integration-defective HIV-1 and EIAV Vectors In Vitro and In Vivo |
| Q30885857 | Augmentation of reverse transcription by integrase through an interaction with host factor, SIP1/Gemin2 Is critical for HIV-1 infection |
| Q54223780 | CLIP-related methodologies and their application to retrovirology. |
| Q52347430 | Characterization of association of human mitochondrial lysyl-tRNA synthetase with HIV-1 Pol and tRNA3Lys. |
| Q40275247 | Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication |
| Q34745316 | Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant |
| Q41841102 | Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus |
| Q37512925 | Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase |
| Q33887759 | Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking |
| Q36707275 | DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition |
| Q51851755 | Design and Potential of Non-Integrating Lentiviral Vectors. |
| Q37620817 | Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells |
| Q37369322 | Development and use of SIV-based Integrase defective lentiviral vector for immunization. |
| Q39712011 | Development of a nonintegrating Rev-dependent lentiviral vector carrying diphtheria toxin A chain and human TRAF6 to target HIV reservoirs |
| Q40532525 | Differences in vector-genome processing and illegitimate integration of non-integrating lentiviral vectors |
| Q39580790 | Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzyme-substrate interactions |
| Q34462660 | Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses. |
| Q37251114 | Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector |
| Q45871959 | Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors. |
| Q33205270 | Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway |
| Q33887338 | Functional RT and IN incorporated into HIV-1 particles independently of the Gag/Pol precursor protein |
| Q34688367 | Gene delivery by lentivirus vectors |
| Q28081911 | Gene therapy for hemophilia |
| Q33782016 | Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase |
| Q42091632 | Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase |
| Q39548591 | Genetic dissociation of the encapsidation and reverse transcription functions in the 5' R region of human immunodeficiency virus type 1 |
| Q33358990 | Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase |
| Q38124090 | HIV integrase inhibitors: 20-year landmark and challenges |
| Q30407372 | HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme. |
| Q37945176 | HIV-1 Integrase-DNA Recognition Mechanisms |
| Q34348888 | HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration. |
| Q35069785 | HIV-1 replication in cell lines harboring INI1/hSNF5 mutations. |
| Q27023387 | HIV-1 reverse transcription |
| Q35038004 | Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk |
| Q35891440 | Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. |
| Q34782531 | Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. |
| Q35076592 | Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag. |
| Q34353549 | Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells |
| Q33653264 | Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex. |
| Q39606712 | Human immunodeficiency virus type 1 replication in the absence of integrase-mediated dna recombination: definition of permissive and nonpermissive T-cell lines |
| Q33785609 | Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells |
| Q33713812 | Hybrid lentivirus-transposon vectors with a random integration profile in human cells. |
| Q37004198 | INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo |
| Q42186812 | Identification of a novel human immunodeficiency virus type 1 integrase interactor, Gemin2, that facilitates efficient viral cDNA synthesis in vivo |
| Q39591194 | Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells. |
| Q37134432 | Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase |
| Q35063298 | Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect |
| Q39642519 | Implication of a central cysteine residue and the HHCC domain of Moloney murine leukemia virus integrase protein in functional multimerization |
| Q35895836 | Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein. |
| Q99635824 | Influence of the amino-terminal sequence on the structure and function of HIV integrase |
| Q34742062 | Inhibition of early stages of HIV-1 assembly by INI1/hSNF5 transdominant negative mutant S6 |
| Q36654542 | Initial Characterization of Integrase-Defective Lentiviral Vectors for Pancreatic Cancer Gene Therapy. |
| Q37353201 | Integrase and integration: biochemical activities of HIV-1 integrase |
| Q33812392 | Integrase-lexA fusion proteins incorporated into human immunodeficiency virus type 1 that contains a catalytically inactive integrase gene are functional to mediate integration |
| Q37506025 | Integration-deficient lentiviral vectors: a slow coming of age. |
| Q36281118 | Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication |
| Q40814997 | Interaction between human immunodeficiency virus type 1 reverse transcriptase and integrase proteins |
| Q35870149 | Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease |
| Q38148784 | Lentiviral vector-mediated RNA silencing in the central nervous system. |
| Q41865429 | Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals |
| Q33637259 | Long-term episomal transgene expression from mitotically stable integration-deficient lentiviral vectors. |
| Q92689026 | Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner |
| Q42971850 | Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication |
| Q36098878 | Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription |
| Q33849672 | Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells |
| Q33651120 | Monoclonal antibodies against the minimal DNA-binding domain in the carboxyl-terminal region of human immunodeficiency virus type 1 integrase |
| Q36916993 | Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration |
| Q35887393 | Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing |
| Q37574479 | Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors |
| Q39589226 | Multiple integrations of human foamy virus in persistently infected human erythroleukemia cells |
| Q39548812 | Mutations in nonconserved domains of Ty3 integrase affect multiple stages of the Ty3 life cycle |
| Q33783966 | Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation. |
| Q34226132 | Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development |
| Q41860075 | Nonintegrating foamy virus vectors |
| Q33564383 | Nonintegrating lentiviral vectors can effectively deliver ovalbumin antigen for induction of antitumor immunity |
| Q34621737 | Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector |
| Q34350236 | Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import |
| Q35980829 | Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression |
| Q27487498 | Protective Antiviral Immunity Conferred by a Nonintegrative Lentiviral Vector-Based Vaccine |
| Q36473812 | Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in IN augment DNA synthesis. |
| Q30341397 | Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase. |
| Q28596842 | Retroviral DNA Integration |
| Q34500837 | Retroviral DNA integration: reaction pathway and critical intermediates |
| Q51003294 | Reverse Transcription of Retroviruses and LTR Retrotransposons. |
| Q35873097 | Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity |
| Q41827820 | Role of integrase in reverse transcription of the Saccharomyces cerevisiae retrotransposon Ty1. |
| Q38735841 | S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection |
| Q39582953 | Sequential deletion of the integrase (Gag-Pol) carboxyl terminus reveals distinct phenotypic classes of defective HIV-1. |
| Q36944674 | Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages |
| Q39581624 | Specific and independent recognition of U3 and U5 att sites by human immunodeficiency virus type 1 integrase in vivo. |
| Q24307975 | Specificity of interaction of INI1/hSNF5 with retroviral integrases and its functional significance |
| Q30009248 | Structural dynamics of native and V260E mutant C-terminal domain of HIV-1 integrase |
| Q35882489 | Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase. |
| Q40883677 | Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents |
| Q33821401 | Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1. |
| Q37090592 | Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles |
| Q45888280 | Transgene expression in the mouse cerebellar Purkinje cells with a minimal level of integration using long terminal repeat-modified lentiviral vectors |
| Q34332190 | Ty3 integrase is required for initiation of reverse transcription |
| Q40584573 | Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants |
| Q39178834 | Use of integrase-minus lentiviral vector for transient expression. |
| Q34206875 | Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity |
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