| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Richard Weindruch | Q115314417 |
| Rozalyn Anderson | Q17505047 | ||
| P2860 | cites work | Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1α | Q60698156 |
| Diet and aging | Q81743360 | ||
| Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue | Q82310590 | ||
| Transcriptional response to aging and caloric restriction in heart and adipose tissue | Q94602388 | ||
| Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase | Q24297207 | ||
| HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells | Q24302194 | ||
| AMPK phosphorylation of raptor mediates a metabolic checkpoint | Q24329244 | ||
| AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity | Q24595845 | ||
| Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression | Q24633031 | ||
| Rapamycin fed late in life extends lifespan in genetically heterogeneous mice | Q24647805 | ||
| Caloric restriction delays disease onset and mortality in rhesus monkeys | Q24655994 | ||
| HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans | Q27312348 | ||
| Inflammation and metabolic disorders | Q27860923 | ||
| MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. | Q27932823 | ||
| p53 regulates mitochondrial respiration | Q28242400 | ||
| The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity | Q28252642 | ||
| Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice | Q28252794 | ||
| Calorie restriction increases muscle mitochondrial biogenesis in healthy humans | Q28763406 | ||
| SIRT1 transgenic mice show phenotypes resembling calorie restriction | Q29301793 | ||
| Meta-analysis of age-related gene expression profiles identifies common signatures of aging. | Q29347048 | ||
| mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex | Q29617214 | ||
| AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha | Q29620443 | ||
| Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase | Q30850845 | ||
| Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program | Q33279846 | ||
| AGEMAP: a gene expression database for aging in mice | Q33310467 | ||
| Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms | Q33312303 | ||
| SirT1 regulates energy metabolism and response to caloric restriction in mice | Q33323365 | ||
| Brain IRS2 signaling coordinates life span and nutrient homeostasis | Q34653913 | ||
| Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. | Q34849088 | ||
| 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila | Q35006474 | ||
| Effect of exercise and calorie restriction on biomarkers of aging in mice | Q35095026 | ||
| Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis | Q35830162 | ||
| Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial | Q35928453 | ||
| Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. | Q35948127 | ||
| Lessons learned from gene expression profile studies of aging and caloric restriction | Q35993750 | ||
| Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. | Q35995047 | ||
| Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response | Q36477428 | ||
| Metabolic reprogramming in dietary restriction | Q36633913 | ||
| Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt | Q36728127 | ||
| Sirt1 protects against high-fat diet-induced metabolic damage | Q36775324 | ||
| Ruminations on dietary restriction and aging. | Q36775332 | ||
| The emerging role of adipokines as mediators of inflammation and immune responses | Q36824371 | ||
| Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver | Q36983911 | ||
| Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1. | Q37038768 | ||
| Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice | Q37039107 | ||
| Post-translational modifications of adiponectin: mechanisms and functional implications. | Q37051360 | ||
| PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells | Q37076957 | ||
| Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction | Q37108121 | ||
| Aging and survival: the genetics of life span extension by dietary restriction. | Q37121798 | ||
| Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. | Q37141764 | ||
| Role of adiponectin in human skeletal muscle bioenergetics | Q37163429 | ||
| Aging impairs skeletal muscle mitochondrial bioenergetic function | Q37214317 | ||
| PGC-1alpha in aging and anti-aging interventions | Q37346326 | ||
| SirT1 gain of function increases energy efficiency and prevents diabetes in mice | Q39332033 | ||
| Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. | Q39842472 | ||
| Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells | Q39917673 | ||
| Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. | Q40200727 | ||
| Tissue-specific regulation of SIRT1 by calorie restriction | Q41298631 | ||
| UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals | Q42065664 | ||
| Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans | Q42247172 | ||
| Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice | Q42521448 | ||
| Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration | Q42805718 | ||
| AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions | Q44482243 | ||
| Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization | Q44965912 | ||
| Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle. | Q46184680 | ||
| Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation | Q46220928 | ||
| Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. | Q46752037 | ||
| Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase | Q46881124 | ||
| Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction | Q47305762 | ||
| Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex | Q47341362 | ||
| Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet. | Q51474615 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | calorie restriction | Q1332886 |
| P304 | page(s) | 134-141 | |
| P577 | publication date | 2009-12-07 | |
| P1433 | published in | Trends in Endocrinology and Metabolism | Q15265727 |
| P1476 | title | Metabolic reprogramming, caloric restriction and aging | |
| P478 | volume | 21 |
| Q35105265 | A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat. |
| Q35242831 | A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. |
| Q38327781 | A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms. |
| Q36037588 | A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons |
| Q42233272 | A role for dicer in aging and stress survival |
| Q42137713 | Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training. |
| Q37179899 | Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding. |
| Q98564744 | Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy |
| Q33638932 | Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids |
| Q34341924 | Aging and energetics' 'Top 40' future research opportunities 2010-2013. |
| Q38121605 | An adipocentric perspective of resveratrol as a calorie restriction mimetic |
| Q91947139 | An expanding GSK3 network: implications for aging research |
| Q89138125 | Antifibrotic role of PGC-1α-siRNA against TGF-β1-induced renal interstitial fibrosis |
| Q53504791 | Arginase I expression is upregulated by dietary restriction in the liver of mice as a function of age. |
| Q35174225 | Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice |
| Q27692538 | Autophagy and cardiovascular aging: lesson learned from rapamycin |
| Q34884241 | Bidirectional metabolic regulation of neurocognitive function |
| Q35166090 | Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective |
| Q46305784 | Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC-1α-eNOS pathway and enhanced autophagy |
| Q37838181 | Caloric restriction and antiaging effects |
| Q35353852 | Caloric restriction and chronic inflammatory diseases |
| Q33706697 | Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle |
| Q41897937 | Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration |
| Q57293796 | Caloric restriction inhibits mammary tumorigenesis in MMTV-ErbB2 transgenic mice through the suppression of ER and ErbB2 pathways and inhibition of epithelial cell stemness in premalignant mammary tissues |
| Q37112847 | Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism |
| Q24568041 | Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys |
| Q35093037 | Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice |
| Q37580813 | Calorie Restriction Attenuates Terminal Differentiation of Immune Cells |
| Q37030282 | Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. |
| Q36838612 | Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study |
| Q37457485 | Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations |
| Q90634693 | Calorie restriction reprograms diurnal rhythms in protein translation to regulate metabolism |
| Q30530392 | Changes in behaviors of male C57BL/6J mice across adult life span and effects of dietary restriction |
| Q36993373 | Chronic caloric restriction partially protects against age-related alteration in serum metabolome |
| Q27003116 | Complex-I-ty in aging |
| Q35799806 | Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice |
| Q36184207 | Diet and aging |
| Q36240273 | Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. |
| Q35823199 | Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan |
| Q37726260 | Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism |
| Q38806386 | Diluted serum from calorie-restricted animals promotes mitochondrial β-cell adaptations and protect against glucolipotoxicity |
| Q34462362 | Diminished mTOR signaling: a common mode of action for endocrine longevity factors. |
| Q28480463 | Down-regulating sphingolipid synthesis increases yeast lifespan |
| Q92636803 | Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys |
| Q27305306 | Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus |
| Q37423562 | Empirical verification of evolutionary theories of aging |
| Q92239610 | Environmental Triggers of Autoreactive Responses: Induction of Antiphospholipid Antibody Formation |
| Q64079418 | Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases |
| Q37933538 | Free will and the obesity epidemic |
| Q27023479 | Gene expression defines natural changes in mammalian lifespan |
| Q36310528 | Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans |
| Q24615803 | Genome-environment interactions that modulate aging: powerful targets for drug discovery |
| Q90570276 | Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle |
| Q90700186 | Growth Hormone Deficiency: Health and Longevity |
| Q38631149 | Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing. |
| Q60928052 | Gut-A Nexus Between Dietary Restriction and Lifespan |
| Q92967400 | Hallmarks of Aging in the Liver |
| Q34253805 | Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase |
| Q60053075 | Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity |
| Q47813385 | How regularities of mortality statistics explain why we age despite having potentially ageless somatic stem cells |
| Q34974748 | Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels |
| Q48097012 | Influence of age-related learning and memory capacity of mice: different effects of a high and low caloric diet |
| Q36072656 | Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice |
| Q57479283 | Linking Lipid Metabolism to Chromatin Regulation in Aging |
| Q36635352 | Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging |
| Q37438826 | Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys |
| Q50966253 | Long-term dietary restriction up-regulates activity and expression of renal arginase II in aging mice. |
| Q28384001 | Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging |
| Q37709586 | Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators |
| Q34358930 | Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid |
| Q92426430 | Metabolic adaptation and maladaptation in adipose tissue |
| Q37655688 | Metabolic and environmental conditions determine nuclear genomic instability in budding yeast lacking mitochondrial DNA. |
| Q36464252 | Metabolic characteristics of long-lived mice |
| Q39910286 | Metabolomic analysis of survival in carbohydrate pre-fed pigs subjected to shock and polytrauma. |
| Q33701382 | Minireview: Metabolism of female reproduction: regulatory mechanisms and clinical implications |
| Q82514835 | Mitochondrial energetics in liver and skeletal muscle after energy restriction in young rats |
| Q38830933 | Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease |
| Q33840673 | NK cell maturation and function in C57BL/6 mice are altered by caloric restriction. |
| Q58617550 | Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice |
| Q39448698 | Non-human primates as a model for aging |
| Q52562880 | Novel role of autophagy-associated Pik3c3 gene in gonadal white adipose tissue browning in aged C57/Bl6 male mice. |
| Q41919316 | Nuclear respiratory factor 2 induces SIRT3 expression. |
| Q46382518 | Nutrition modulation of human aging: The calorie restriction paradigm |
| Q46128800 | Nutritional Control of Chronological Aging and Heterochromatin in Saccharomyces cerevisiae |
| Q33714263 | On the Relationship between Energy Metabolism, Proteostasis, Aging and Parkinson's Disease: Possible Causative Role of Methylglyoxal and Alleviative Potential of Carnosine |
| Q34763027 | Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning |
| Q36017799 | Patterns of gene expression in the sheep heart during the perinatal period revealed by transcriptomic modeling |
| Q51776499 | Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age. |
| Q92394724 | Plausible Links Between Metabolic Networks, Stem Cells, and Longevity |
| Q99727654 | Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction |
| Q60301971 | Preconditioning lessens high fat induced metabolic syndrome along with markers of increased metabolic capacity in muscle and adipose tissue |
| Q59799860 | Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol |
| Q36466185 | Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans |
| Q38660882 | Redox homeostasis and age-related deficits in neuromuscular integrity and function. |
| Q52733443 | Reduced metabolic rate and oxygen radicals production in stored insect sperm. |
| Q35828719 | Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction |
| Q37799059 | Regulation of intermediary metabolism by protein acetylation |
| Q39271427 | SIRT-ain relief from age-inducing stress |
| Q24628734 | Short-term calorie restriction enhances skeletal muscle stem cell function |
| Q54351322 | Short-term calorie restriction improves glucose homeostasis in old rats: involvement of AMPK. |
| Q35779124 | Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction |
| Q42849511 | Slowing Polycystic Kidney Disease by Fasting |
| Q41907365 | Somatic growth, aging, and longevity |
| Q49035818 | Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors |
| Q27022690 | T cell replicative senescence in human aging |
| Q45109894 | Taking the rap: multiple effects of blocking mammalian target of rapamycin |
| Q35675797 | The Role of Storage Lipids in the Relation between Fecundity, Locomotor Activity, and Lifespan of Drosophila melanogaster Longevity-Selected and Control Lines |
| Q36995228 | The caloric restriction paradigm: implications for healthy human aging |
| Q41866481 | The free radical theory of aging is dead. Long live the damage theory! |
| Q34306443 | The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction |
| Q36380652 | The influence of shc proteins and aging on whole body energy expenditure and substrate utilization in mice |
| Q33893799 | The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer |
| Q34403988 | The molecular and metabolic influence of long term agmatine consumption |
| Q38143696 | The role of protein conformational switches in pharmacology: its implications in metabolic reprogramming and protein evolution |
| Q39912054 | Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity |
| Q26992046 | Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressor |
| Q37608825 | Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains |
| Q45741097 | Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins |
| Q34193337 | Vascular and metabolic dysfunction in Alzheimer's disease: a review |
| Q33593869 | Yeast as a model to understand the interaction between genotype and the response to calorie restriction |
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