A Divergent Substrate-Binding Loop within the Pro-oncogenic Protein Anterior Gradient-2 Forms a Docking Site for Reptin

scientific article published on December 3, 2010

A Divergent Substrate-Binding Loop within the Pro-oncogenic Protein Anterior Gradient-2 Forms a Docking Site for Reptin is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JMB.2010.09.035
P953full work available at URLhttps://era.ed.ac.uk/bitstream/1842/6477/2/Maslon2012.pdf
https://api.elsevier.com/content/article/PII:S0022283610010235?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0022283610010235?httpAccept=text/xml
P698PubMed publication ID20888340

P2093author name stringRoman Hrstka
Borek Vojtesek
Ted R. Hupp
Magdalena M. Maslon
P2860cites workIntrinsically Disordered Proteins in Human Diseases: Introducing the D 2 ConceptQ22061726
hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycanQ24294965
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decayQ24306010
The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damageQ24309068
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assemblyQ24313436
The protein disulfide isomerase AGR2 is essential for production of intestinal mucusQ24314611
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activityQ24597019
Molecular basis for the nerve dependence of limb regeneration in an adult vertebrateQ24645387
Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimerQ27632929
Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductaseQ27654630
A comprehensive two-hybrid analysis to explore the yeast protein interactomeQ27861093
Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein familyQ28254595
AAA+ proteins: have engine, will workQ29617410
RVB1/RVB2: running rings around molecular biologyQ30435879
Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexesQ30438402
Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomasQ31167775
hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell linesQ31990261
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discoveryQ33205643
Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.Q33920019
Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancerQ33921644
The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancersQ34119671
Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily memberQ34199026
A sticky problem: the Xenopus cement gland as a paradigm for anteroposterior patterningQ34401219
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexesQ34411407
AGR2, an androgen-inducible secretory protein overexpressed in prostate cancerQ34411990
Prognostic relevance of AGR2 expression in breast cancerQ34504011
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasisQ34525800
Drosophila Reptin and other TIP60 complex components promote generation of silent chromatinQ34544018
Dodecameric structure and ATPase activity of the human TIP48/TIP49 complexQ34589231
Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2.Q34712443
The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformationQ34736863
Control of transcription by Pontin and ReptinQ36744369
Pontin and reptin, two related ATPases with multiple roles in cancer.Q37256105
Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins.Q39779420
Prognostic significance of AGR2 in pancreatic ductal adenocarcinomaQ39824226
Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinomaQ40101677
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcriptionQ43095790
Refinement of the Coomassie brilliant blue G assay for quantitative protein determination.Q50890041
The molecular dynamics of MDM2.Q53326269
The Anterior Gradient-2 Pathway as a Model for Developing Peptide-Aptamer Anti-Cancer Drug Leads that Stimulate p53 FunctionQ61740022
Is nitrocellulose filter binding really a universal assay for protein-DNA interactions?Q74602750
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)418-438
P577publication date2010-10-01
2010-12-03
P1433published inJournal of Molecular BiologyQ925779
P1476titleA divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin
A Divergent Substrate-Binding Loop within the Pro-oncogenic Protein Anterior Gradient-2 Forms a Docking Site for Reptin
P478volume404

Reverse relations

cites work (P2860)
Q89004805AAA+ ATPases Reptin and Pontin as potential diagnostic and prognostic biomarkers in salivary gland cancer - a short report
Q21132306Anterior gradient protein-2 is a regulator of cellular adhesion in prostate cancer
Q64916309Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
Q35159146Cytoplasmic expression of pontin in renal cell carcinoma correlates with tumor invasion, metastasis and patients' survival
Q34777828Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein.
Q41006421Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin
Q38040355Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development.
Q39006763Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2.
Q47362690Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.
Q48364803FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas
Q28484118Identification, characterization and application of a G-quadruplex structured DNA aptamer against cancer biomarker protein anterior gradient homolog 2
Q93080668Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer
Q90695386Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis
Q52616823Mapping a noncovalent protein-peptide interface by top-down FTICR mass spectrometry using electron capture dissociation.
Q90399266Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma
Q34044556Structure of Yin Yang 1 oligomers that cooperate with RuvBL1-RuvBL2 ATPases
Q39195622The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.
Q41539424The Role of Pontin and Reptin in Cellular Physiology and Cancer Etiology
Q30410169The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape
Q36903188The estrogen-regulated anterior gradient 2 (AGR2) protein in breast cancer: a potential drug target and biomarker
Q24630889The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development
Q50020631The sequence-specific peptide-binding activity of the protein sulfide isomerase AGR2 directs its' stable binding to the oncogenic receptor EpCAM.

Search more.