Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum

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Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PNTD.0005620
P932PMC publication ID5444850
P698PubMed publication ID28505185

P50authorGuy CaljonQ37320107
P2093author name stringLouis Maes
Paul Cos
Peter Delputte
Sarah Hendrickx
Dorien Mabille
Magali Van den Kerkhof
P2860cites workDevelopment and characterization of paromomycin-resistant Leishmania donovani promastigotesQ77352855
Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasisQ28271849
Single-dose liposomal amphotericin B for visceral leishmaniasis in IndiaQ28272916
Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncomplianceQ28285948
Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocolQ28483977
Leishmania donovani develops resistance to drug combinationsQ28484463
Miltefosine and antimonial drug susceptibility of Leishmania Viannia species and populations in regions of high transmission in ColombiaQ28539068
In vitro and in vivo miltefosine susceptibility of a Leishmania amazonensis isolate from a patient with diffuse cutaneous leishmaniasisQ28540828
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct MechanismsQ28554770
Epidemiology of visceral leishmaniasisQ33583456
In vitro and in vivo interactions between miltefosine and other antileishmanial drugsQ34301638
Injectable paromomycin for Visceral leishmaniasis in IndiaQ34639916
In Vivo Selection of Paromomycin and Miltefosine Resistance in Leishmania donovani and L. infantum in a Syrian Hamster ModelQ35859984
Miltefosine in the treatment of leishmaniasis: Clinical evidence for informed clinical risk management.Q36645795
Therapeutic options for visceral leishmaniasisQ37333942
Treatment failure and miltefosine susceptibility in dermal leishmaniasis caused by Leishmania subgenus Viannia species.Q37544280
Laboratory confirmed miltefosine resistant cases of visceral leishmaniasis from IndiaQ37615730
Elucidation of cellular mechanisms involved in experimental paromomycin resistance in Leishmania donovaniQ37712969
The treatment of visceral leishmaniasis: safety and efficacyQ38261232
Lack of correlation between the promastigote back-transformation assay and miltefosine treatment outcomeQ39063747
Efficacy and safety of single-dose liposomal amphotericin B for visceral leishmaniasis in a rural public hospital in Bangladesh: a feasibility studyQ39262437
Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovaniQ39436217
The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine.Q39614531
The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of BrazilQ39731039
Drug resistance in leishmaniasisQ41271991
In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differencesQ41844113
Leishmania resistance to miltefosine associated with genetic markerQ42573934
Experimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L. infantumQ46921246
Immunomodulatory effect of picroliv on the efficacy of paromomycin and miltefosine in combination in experimental visceral leishmaniasisQ51771774
Evidence of a drug-specific impact of experimentally selected paromomycin and miltefosine resistance on parasite fitness in Leishmania infantum.Q53120855
Intracellular amastigote replication may not be required for successful in vitro selection of miltefosine resistance in Leishmania infantum.Q53541333
Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trialQ56804080
Kala-azar elimination programme in IndiaQ64132519
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmiltefosineQ411787
paromomycinQ415625
Leishmania infantumQ1950789
drug resistanceQ12147416
P304page(s)e0005620
P577publication date2017-05-15
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titleCombined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum
P478volume11