Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol

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Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PNTD.0001664
P3181OpenCitations bibliographic resource ID2023442
P932PMC publication ID3362622
P698PubMed publication ID22666513
P5875ResearchGate publication ID225184802

P50authorShyam SundarQ58941021
Poonam SalotraQ28869475
P2093author name stringJean-Claude Dujardin
Suman Rijal
Louis Maes
Paul Cos
Vasundhra Bhandari
Kristel Kuypers
Sarah Hendrickx
Julien Lonchamp
Craig D Shaw
Katharine Carter
Raquel Andrea Inocêncio da Luz
P2860cites workIn vivo interference of paromomycin with mitochondrial activity of Leishmania.Q50529065
Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells.Q51765295
A prospective randomized, comparative, open-label trial of the safety and efficacy of paromomycin (aminosidine) plus sodium stibogluconate versus sodium stibogluconate alone for the treatment of visceral leishmaniasis.Q53900097
Analysis of stage-specific expression of basic proteins in Leishmania infantumQ62579648
Kala-azar elimination programme in IndiaQ64132519
Development and characterization of paromomycin-resistant Leishmania donovani promastigotesQ77352855
Expression profiling by whole-genome interspecies microarray hybridization reveals differential gene expression in procyclic promastigotes, lesion-derived amastigotes, and axenic amastigotes in Leishmania mexicanaQ82344940
Paromomycin in the treatment of leishmaniasisQ94699168
Metabolomics to unveil and understand phenotypic diversity between pathogen populationsQ28476399
Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencingQ28480626
Drug resistance in leishmaniasisQ29616242
Barriers to treatment for visceral leishmaniasis in hyperendemic areas: India, Bangladesh, Nepal, Brazil and SudanQ33603346
Paromomycin for the Treatment of Visceral Leishmaniasis in Sudan: A Randomized, Open-Label, Dose-Finding StudyQ33737825
Injectable paromomycin for Visceral leishmaniasis in IndiaQ34639916
ParomomycinQ34864208
Antimony-resistant clinical isolates of Leishmania donovani are susceptible to paromomycin and sitamaquineQ35005213
In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania speciesQ35006918
Visceral leishmaniasis - current therapeutic modalities.Q36508340
Drug unresponsiveness & combination therapy for kala-azarQ36508353
Combination therapy for visceral leishmaniasisQ37698756
Biofilms: an extra hurdle for effective antimicrobial therapyQ37740154
In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differencesQ41844113
Paromomycin: uptake and resistance in Leishmania donovani.Q41855565
In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cellsQ41901399
Treatment of Visceral Leishmaniasis in 2010: Direction From Bihar State, IndiaQ42879827
Stage specific developmental changes in the mitochondrial and surface membrane associated redox systems of Leishmania donovani promastigote and amastigoteQ42975045
Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometryQ43019143
Treatment of kala-azar in southern Sudan using a 17-day regimen of sodium stibogluconate combined with paromomycin: a retrospective comparison with 30-day sodium stibogluconate monotherapy.Q43953352
Antigen genes for molecular epidemiology of leishmaniasis: polymorphism of cysteine proteinase B and surface metalloprotease glycoprotein 63 in the Leishmania donovani complexQ44785806
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectantimonyQ1099
paromomycinQ415625
infectious diseaseQ18123741
P304page(s)e1664
P577publication date2012-01-01
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titleExperimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol
P478volume6

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cites work (P2860)
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Q28550306Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain
Q34328882Developments in diagnosis and treatment of visceral leishmaniasis during the last decade and future prospects
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Q42379574Transcriptome profiling identifies genes/pathways associated with experimental resistance to paromomycin in Leishmania donovani

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