Experimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L. infantum

scientific article published on 11 March 2014

Experimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L. infantum is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00436-014-3835-7
P698PubMed publication ID24615359
P5875ResearchGate publication ID260683686

P50authorSarah HendrickxQ94593639
P2093author name stringP Cos
J C Dujardin
L Maes
P Delputte
L Lachaud
G Boulet
S Rijal
A Mondelaers
P2860cites workWhole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistanceQ24633552
Pentavalent antimonials: new perspectives for old drugsQ28253055
Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasisQ28271849
Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncomplianceQ28285948
Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocolQ28483977
Leishmania donovani develops resistance to drug combinationsQ28484463
Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?Q29038941
Aminoglycosides: activity and resistanceQ33548221
Oral miltefosine for Indian visceral leishmaniasisQ34529393
Injectable paromomycin for Visceral leishmaniasis in IndiaQ34639916
ParomomycinQ34864208
Antimony resistance in leishmania, focusing on experimental researchQ35607561
Miltefosine in the treatment of leishmaniasis: Clinical evidence for informed clinical risk management.Q36645795
Combination therapy for visceral leishmaniasisQ37698756
Drug resistance in Indian visceral leishmaniasisQ39222666
Validation of a simple resazurin-based promastigote assay for the routine monitoring of miltefosine susceptibility in clinical isolates of Leishmania donovaniQ39226324
Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).Q39444314
In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differencesQ41844113
In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cellsQ41901399
Leishmania resistance to miltefosine associated with genetic markerQ42573934
Implementation research to support the initiative on the elimination of kala azar from Bangladesh, India and Nepal--the challenges for diagnosis and treatmentQ44379606
Antigen genes for molecular epidemiology of leishmaniasis: polymorphism of cysteine proteinase B and surface metalloprotease glycoprotein 63 in the Leishmania donovani complexQ44785806
In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania speciesQ59275048
Kala-azar elimination programme in IndiaQ64132519
Development and characterization of paromomycin-resistant Leishmania donovani promastigotesQ77352855
Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of useQ84100557
P433issue5
P921main subjectmiltefosineQ411787
paromomycinQ415625
Leishmania donovaniQ1950752
P304page(s)1875-1881
P577publication date2014-03-11
P1433published inParasitology ResearchQ15755242
P1476titleExperimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L. infantum
P478volume113

Reverse relations

cites work (P2860)
Q39014776Artemisinin and its derivatives in treating protozoan infections beyond malaria
Q33728704Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum
Q28550306Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain
Q39560646Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance.
Q39014583Evaluating drug resistance in visceral leishmaniasis: the challenges
Q53120855Evidence of a drug-specific impact of experimentally selected paromomycin and miltefosine resistance on parasite fitness in Leishmania infantum.
Q28546940Fitness and Phenotypic Characterization of Miltefosine-Resistant Leishmania major
Q37023262Genomic Appraisal of the Multifactorial Basis for In Vitro Acquisition of Miltefosine Resistance in Leishmania donovani
Q36001763Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes
Q60303363Immunosuppression of Syrian golden hamsters accelerates relapse but not the emergence of resistance in Leishmania infantum following recurrent miltefosine pressure
Q90125299Impaired development of a miltefosine-resistant Leishmania infantum strain in the sand fly vectors Phlebotomus perniciosus and Lutzomyia longipalpis
Q35859984In Vivo Selection of Paromomycin and Miltefosine Resistance in Leishmania donovani and L. infantum in a Syrian Hamster Model
Q46481419In vitro 'time-to-kill' assay to assess the cidal activity dynamics of current reference drugs against Leishmania donovani and Leishmania infantum
Q28540828In vitro and in vivo miltefosine susceptibility of a Leishmania amazonensis isolate from a patient with diffuse cutaneous leishmaniasis
Q50051086In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series.
Q30380900In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization.
Q53541333Intracellular amastigote replication may not be required for successful in vitro selection of miltefosine resistance in Leishmania infantum.
Q39063747Lack of correlation between the promastigote back-transformation assay and miltefosine treatment outcome
Q35801671Leishmania is not prone to develop resistance to tamoxifen
Q40614369Molecular detection of infection homogeneity and impact of miltefosine treatment in a Syrian golden hamster model of Leishmania donovani and L. infantum visceral leishmaniasis.
Q89842729Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection
Q91836148Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate
Q58562873Visceral leishmaniasis and HIV coinfection: current perspectives
Q36887740Zinc(II)-Dipicolylamine Coordination Complexes as Targeting and Chemotherapeutic Agents for Leishmania major

Search more.