A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination

scientific article

A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELREP.2014.04.035
P932PMC publication ID4057996
P698PubMed publication ID24857654
P5875ResearchGate publication ID262608999

P50authorJulia E R WilkersonQ78305820
Marina A MaksimovaQ85763514
P2093author name stringHao Wu
Jay R Gibson
Kimberly M Huber
Kristofer W Loerwald
Nien-Pei Tsai
Jason B Dictenberg
Nicole P Cabalo
P2860cites workMultiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95Q24306675
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion proteinQ24322990
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and functionQ24608468
A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome.Q24644826
Synapse elimination accompanies functional plasticity in hippocampal neuronsQ24652504
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor traffickingQ24681745
The pathophysiology of fragile X (and what it teaches us about synapses)Q27010675
The FMRP regulon: from targets to disease convergenceQ27014002
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse numberQ28297899
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and functionQ28507026
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTPQ28511269
Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβQ28513918
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expressionQ28566984
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTDQ28585633
Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy imagesQ28755127
Rayburst sampling, an algorithm for automated three-dimensional shape analysis from laser scanning microscopy imagesQ29028421
Experience-dependent structural synaptic plasticity in the mammalian brainQ29619661
Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendritesQ30472808
Multiplexed dendritic targeting of alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathwayQ30481838
mGluR5 has a critical role in inhibitory learning.Q30486477
Arc regulates spine morphology and maintains network stability in vivo.Q30497140
Persistent synapse loss induced by repetitive LTD in developing rat hippocampal neuronsQ33570561
Dendritic spine structural anomalies in fragile-X mental retardation syndromeQ33919487
Localization and translation of mRNA in dendrites and axonsQ33956250
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activityQ34169306
Neuronal activity-regulated gene transcription in synapse development and cognitive functionQ34183712
Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndromeQ34200046
mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation.Q34432930
Arc-dependent synapse-specific homeostatic plasticityQ34490539
Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.Q34579673
Experience-dependent structural plasticity in the cortexQ34778187
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depressionQ34948804
Differential regulation of spontaneous and evoked neurotransmitter release at central synapsesQ34975491
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.Q35949697
Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakeningQ36568016
Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rateQ36966248
Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticityQ36990250
Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.Q37068389
Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selectionQ37070840
Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depressionQ37241695
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and functionQ37279404
Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapsesQ37329645
mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortexQ37352265
Protein translation in synaptic plasticity: mGluR-LTD, Fragile X.Q37467921
Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmissionQ37632803
New views of Arc, a master regulator of synaptic plasticityQ37833492
Climbing fiber synapse elimination in cerebellar Purkinje cellsQ37958915
Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampusQ39757955
Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2.Q40372504
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.Q40817289
Microfluidic local perfusion chambers for the visualization and manipulation of synapsesQ40829704
Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.Q41779911
Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptorsQ41825065
Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activityQ41915034
Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.Q44978632
Refining the phenotype associated with MEF2C haploinsufficiency.Q48227906
Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation.Q48232839
MEF2 negatively regulates learning-induced structural plasticity and memory formationQ48411990
In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex.Q48461077
P433issue5
P304page(s)1589-1600
P577publication date2014-05-22
P1433published inCell ReportsQ5058165
P1476titleA role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination
P478volume7

Reverse relations

cites work (P2860)
Q64278585A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2
Q26796248A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression
Q57793727Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior
Q28069757Advancing the understanding of autism disease mechanisms through genetics
Q90243427Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling
Q42059359Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion
Q36600833Control of spine maturation and pruning through proBDNF synthesized and released in dendrites
Q88535420Dendritic Spine Elimination: Molecular Mechanisms and Implications
Q41691925Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D
Q26782948Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism
Q50469906Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology.
Q39063317FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination
Q52316112Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females.
Q52626735MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.
Q30370553MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.
Q28554014Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
Q97520122Palmitoylated Proteins in Dendritic Spine Remodeling
Q61805117Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Q47752204Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease
Q55163927Synapse development organized by neuronal activity-regulated immediate-early genes.
Q60938189Synaptopathology Involved in Autism Spectrum Disorder
Q39414457The Effects of Hallucinogens on Gene Expression
Q92278141The metabotropic glutamate receptor subtype 1 regulates development and maintenance of lemniscal synaptic connectivity in the somatosensory thalamus
Q54254308The tumor suppressor p53 guides GluA1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity.
Q39296630Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development

Search more.