The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice

scientific article

The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.73.5.2873-2880.2005
P932PMC publication ID1087332
P698PubMed publication ID15845493
P5875ResearchGate publication ID7893074

P2093author name stringWai-Leung Ng
Malcolm E Winkler
Michelle Wright Valderas
R Martin Roop
Gregory T Robertson
John M Richardson
Vanessa K Grippe
Jason M Gee
Michael E Kovach
P2860cites workEfficient translation of the RpoS sigma factor in Salmonella typhimurium requires host factor I, an RNA-binding protein encoded by the hfq geneQ24643457
The Brucella abortus host factor I (HF-I) protein contributes to stress resistance during stationary phase and is a major determinant of virulence in miceQ47910975
Bacterial [Cu,Zn]-superoxide dismutase: phylogenetically distinct from the eukaryotic enzyme, and not so rare after all!Q48071165
The regulation and role of the periplasmic copper, zinc superoxide dismutase of Escherichia coliQ50126760
What is the nature of the replicative niche of a stealthy bug named Brucella?Q51670669
Temporal development of protective cell-mediated and humoral immunity in BALB/c mice infected with Brucella abortus.Q54340852
Mapping and identification of Brucella melitensis proteins by two-dimensional electrophoresis and microsequencing.Q54574075
Escherichia coli expresses a copper- and zinc-containing superoxide dismutase.Q54625893
Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutaseQ68355661
Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine OxidaseQ71635127
Immune control of Brucella abortus 2308 infections in BALB/c miceQ77369300
Role of oxidants in microbial pathophysiologyQ24683780
An iron-containing superoxide dismutase from Escherichia coliQ28240332
Superoxide dismutase from escherichia coli B. A new manganese-containing enzymeQ28247864
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)Q28252462
Cu,Zn superoxide dismutase of Mycobacterium tuberculosis contributes to survival in activated macrophages that are generating an oxidative burstQ28487322
Superoxide radical and superoxide dismutasesQ29614204
Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettesQ29615258
Brucella abortus deficient in copper/zinc superoxide dismutase is virulent in BALB/c miceQ33214205
The Brucella abortus CcrM DNA methyltransferase is essential for viability, and its overexpression attenuates intracellular replication in murine macrophagesQ33602895
Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase.Q33740986
Reactive oxygen and reactive nitrogen intermediates in innate and specific immunityQ33840513
Effects of opsonization and gamma interferon on growth of Brucella melitensis 16M in mouse peritoneal macrophages in vitroQ34003056
Characterization of heat, oxidative, and acid stress responses in Brucella melitensis.Q34004446
Hfq, a new chaperoning role: binding to messenger RNA determines access for small RNA regulatorQ34107548
Effects of cytokines on intracellular growth of Brucella abortus.Q34521159
Characterization and genetic complementation of a Brucella abortus high-temperature-requirement A (htrA) deletion mutant.Q34539325
Brucella intracellular life: from invasion to intracellular replicationQ34987707
Cloning, expression, and occurrence of the Brucella Cu-Zn superoxide dismutase.Q35104059
BrucellaStationary-Phase Gene Expression and VirulenceQ35121003
Metabolic activation of phenols by stimulated neutrophils: a concept for a selective type of anti-inflammatory drugQ35222501
The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytesQ35530228
Function and stationary-phase induction of periplasmic copper-zinc superoxide dismutase and catalase/peroxidase in Caulobacter crescentusQ35596824
Adaptation of the Brucellae to their intracellular nicheQ35752932
Function of periplasmic copper-zinc superoxide dismutase in Caulobacter crescentusQ35908983
The iron superoxide dismutase of Legionella pneumophila is essential for viabilityQ36108555
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activityQ36348121
Virulent Salmonella typhimurium has two periplasmic Cu, Zn-superoxide dismutasesQ36398159
Construction of Cu-Zn superoxide dismutase deletion mutants of Brucella abortus: analysis of survival in vitro in epithelial and phagocytic cells and in vivo in miceQ36947807
Deletion of the BCSP31 gene of Brucella abortus by replacementQ36988580
An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide DismutaseQ37475826
Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophagesQ39730098
The RNA-binding protein HF-I plays a global regulatory role which is largely, but not exclusively, due to its role in expression of the sigmaS subunit of RNA polymerase in Escherichia coliQ39843978
The nutrition of brucellae.Q39852818
Intracellular production of superoxide radical and of hydrogen peroxide by redox active compoundsQ40256778
Survival of hunger and stress: the role of rpoS in early stationary phase gene regulation in E. coliQ40871460
A protein isolated from Brucella abortus is a Cu-Zn superoxide dismutaseQ41193309
Role of Escherichia coli rpoS and associated genes in defense against oxidative damageQ41235661
Isolation of Salmonella mutants defective for intracellular survivalQ41501965
Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxideQ41520592
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectBrucella abortusQ11353905
experimental infectionQ107184421
P304page(s)2873-2880
P577publication date2005-05-01
P1433published inInfection and ImmunityQ6029193
P1476titleThe Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice
P478volume73

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cites work (P2860)
Q33770622A 6-Nucleotide Regulatory Motif within the AbcR Small RNAs of Brucella abortus Mediates Host-Pathogen Interactions
Q41108078A LysR-family transcriptional regulator required for virulence in Brucella abortus is highly conserved among the α-proteobacteria
Q35098688A genome-wide MeSH-based literature mining system predicts implicit gene-to-gene relationships and networks
Q33250270BBP: Brucella genome annotation with literature mining and curation
Q90274560Brucella - Virulence Factors, Pathogenesis and Treatment
Q36313890Brucella abortus requires the heme transporter BhuA for maintenance of chronic infection in BALB/c mice
Q38508267Brucella melitensis, B. neotomae and B. ovis elicit common and distinctive macrophage defense transcriptional responses
Q42633862Brucella suis prevents human dendritic cell maturation and antigen presentation through regulation of tumor necrosis factor alpha secretion
Q34742721Brucella: a pathogen without classic virulence genes.
Q40166228Characterization of SodC, a periplasmic superoxide dismutase from Burkholderia cenocepacia
Q35661526Characterization of outer membrane vesicles from Brucella melitensis and protection induced in mice
Q36197479Characterization of the organic hydroperoxide resistance system of Brucella abortus 2308.
Q55338658Chemical Warfare at the Microorganismal Level: A Closer Look at the Superoxide Dismutase Enzymes of Pathogens.
Q34150771Comparative Study of the Roles of AhpC and KatE as Respiratory Antioxidants inBrucella abortus2308
Q36782115Comparative genomic analysis of Brucella abortus vaccine strain 104M reveals a set of candidate genes associated with its virulence attenuation
Q28078686Contrasting Lifestyles Within the Host Cell
Q57006958Control ofListeriaSuperoxide Dismutase by Phosphorylation
Q35490806Coordinated zinc homeostasis is essential for the wild-type virulence of Brucella abortus
Q40433323CtrA controls cell division and outer membrane composition of the pathogen Brucella abortus
Q37602574Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic
Q33838288DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine
Q34721093Deletion of znuA virulence factor attenuates Brucella abortus and confers protection against wild-type challenge
Q43433173DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate
Q35075335Detection and quantification of superoxide formed within the periplasm of Escherichia coli
Q36984003Differential gene regulation in Yersinia pestis versus Yersinia pseudotuberculosis: effects of hypoxia and potential role of a plasmid regulator
Q36804708Diverse genetic regulon of the virulence-associated transcriptional regulator MucR in Brucella abortus 2308.
Q35563989Either periplasmic tethering or protease resistance is sufficient to allow a SodC to protect Salmonella enterica serovar Typhimurium from phagocytic superoxide.
Q43110895Evaluating the virulence of a Brucella melitensis hemagglutinin gene in the caprine model
Q37033111Four superoxide dismutases contribute to Bacillus anthracis virulence and provide spores with redundant protection from oxidative stress
Q33334401Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes
Q37008662Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses.
Q60907519Identification of Cross-Protective Potential Antigens against Pathogenic spp. through Combining Pan-Genome Analysis with Reverse Vaccinology
Q33760941Identification of a single-nucleotide insertion in the promoter region affecting the sodC promoter activity in Brucella neotomae
Q34280799Identification of two small regulatory RNAs linked to virulence in Brucella abortus 2308.
Q34972692Impact of Hfq on global gene expression and intracellular survival in Brucella melitensis
Q39378480Inactivation of the sodA gene of Streptococcus suis type 2 encoding superoxide dismutase leads to reduced virulence to mice
Q37988968Internal affairs: investigating the Brucella intracellular lifestyle
Q37157099Interplay between two RND systems mediating antimicrobial resistance in Brucella suis.
Q40074631Killing of Brucella antigen-sensitized macrophages by T lymphocytes in bovine brucellosis
Q37353570Metal acquisition and virulence in Brucella
Q47133480Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT-rich core DNA-target site and oligomerization ability.
Q54260204Overexpression of Cu-Zn SOD in Brucella abortus suppresses bacterial intracellular replication via down-regulation of Sar1 activity.
Q31120278PHIDIAS: a pathogen-host interaction data integration and analysis system
Q38686801Proline utilization system is required for infection by the pathogenic α-proteobacterium Brucella abortus.
Q35996766Proteomic Profile of Brucella abortus-Infected Bovine Chorioallantoic Membrane Explants
Q33705174Proteomic alterations explain phenotypic changes in Sinorhizobium meliloti lacking the RNA chaperone Hfq.
Q46873078Proteomic analyses of the time course responses of mice infected with Brucella abortus 544 reveal immunogenic antigens
Q54253141RETRACTED: A small non-coding RNA AbcR2 regulate gntR transcription factor that modulate the intracellular survival of Brucella melitensis.
Q33700813RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity.
Q36646314Regulatory and structural differences in the Cu,Zn-superoxide dismutases of Salmonella enterica and their significance for virulence
Q47607049Role of HdeA in acid resistance and virulence in Brucella abortus 2308.
Q41847875Role of the NiFe hydrogenase Hya in oxidative stress defense in Geobacter sulfurreducens
Q36524042SodA is a major metabolic antioxidant in Brucella abortus 2308 that plays a significant, but limited, role in the virulence of this strain in the mouse model
Q33513755Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens
Q35865584Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen
Q28563582Structural properties of periplasmic SodCI that correlate with virulence in Salmonella enterica serovar Typhimurium
Q36297476Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus
Q35075325Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence
Q37270179Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host
Q36483235The AraC-like transcriptional regulator DhbR is required for maximum expression of the 2,3-dihydroxybenzoic acid biosynthesis genes in Brucella abortus 2308 in response to iron deprivation
Q34353973The Brucella abortus xthA-1 gene product participates in base excision repair and resistance to oxidative killing but is not required for wild-type virulence in the mouse model
Q90574064The Cation Diffusion Facilitator Family Protein EmfA Confers Resistance to Manganese Toxicity in Brucella abortus 2308 and Is an Essential Virulence Determinant in Mice
Q34226643The RNA chaperone Hfq independently coordinates expression of the VirB type IV secretion system and the LuxR-type regulator BabR in Brucella abortus 2308
Q37036082The RNA chaperone Hfq promotes fitness of Actinobacillus pleuropneumoniae during porcine pleuropneumonia
Q52597911The endoribonuclease YbeY is linked to proper cellular morphology and virulence in Brucella abortus.
Q45091061The ferrous iron transporter FtrABCD is required for the virulence of Brucella abortus 2308 in mice
Q38071791The impact of Toll-like receptors on bacterial virulence strategies
Q37274852The manganese transporter MntH is a critical virulence determinant for Brucella abortus 2308 in experimentally infected mice
Q57056831The manganese-dependent pyruvate kinase PykM is required for wild-type glucose utilization by 2308 and its virulence in C57BL/6 mice
Q34634659The predicted ABC transporter AbcEDCBA is required for type IV secretion system expression and lysosomal evasion by Brucella ovis.
Q35759782The symbiosis regulator CbrA modulates a complex regulatory network affecting the flagellar apparatus and cell envelope proteins
Q34501223Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing
Q40536993Vaccination with a ΔnorD ΔznuA Brucella abortus mutant confers potent protection against virulent challenge

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