Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host

scientific article published on 22 September 2009

Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00430-009-0123-8
P932PMC publication ID3814008
P698PubMed publication ID19830453

P2093author name stringClayton C Caswell
R Martin Roop
Daniel W Martin
Eric S Anderson
Jennifer M Gaines
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Identification and characterization of in vivo attenuated mutants of Brucella melitensisQ30957299
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Effect of Brucella abortus lipopolysaccharide on oxidative metabolism and lysozyme release by human neutrophilsQ36943997
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In vitro Brucella suis infection prevents the programmed cell death of human monocytic cellsQ39513799
Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models.Q39518014
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The outer membranes of Brucella spp. are resistant to bactericidal cationic peptidesQ39822692
Deletion of purE attenuates Brucella melitensis 16M for growth in human monocyte-derived macrophagesQ39822825
Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion systemQ39914768
Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteinsQ40004721
Blue-light-activated histidine kinases: two-component sensors in bacteria.Q40089859
Identification of 2,3-dihydroxybenzoic acid as a Brucella abortus siderophoreQ40152024
Attenuated bioluminescent Brucella melitensis mutants GR019 (virB4), GR024 (galE), and GR026 (BMEI1090-BMEI1091) confer protection in miceQ40290565
Nonacid-fast bacteria and HeLa cells: their uptake and subsequent intracellular growth.Q40316366
High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, B. abortus, and B. melitensis.Q40381512
Brucella abortusd-alanyl-D-alanine carboxypeptidase contributes to its intracellular replication and resistance against nitric oxide.Q40479609
Zinc uptake system (znuA locus) of Brucella abortus is essential for intracellular survival and virulence in miceQ40524195
Brucella abortus rough mutants are cytopathic for macrophages in cultureQ40582464
Brucella abortus strain 2308 produces brucebactin, a highly efficient catecholic siderophore.Q40752306
Brucella abortus catalase is a periplasmic protein lacking a standard signal sequenceQ35981327
Aquisition, mobilization and utilization of cellular iron and heme: endless findings and growing evidence of tight regulationQ36063092
BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulenceQ36097211
A chromosomally encoded two-component sensory transduction system is required for virulence of Agrobacterium tumefaciens.Q36123113
Trophoblast cells of ruminant placentas--A minireviewQ36206922
Role for 2-linked-beta-D-glucan in the virulence of Agrobacterium tumefaciensQ36277469
Brucella abortus requires the heme transporter BhuA for maintenance of chronic infection in BALB/c miceQ36313890
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulumQ36371637
The new global map of human brucellosis.Q36378602
ppGpp: stringent response and survival.Q36428957
Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse modelQ36446838
Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c miceQ33288192
Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infectionQ33291121
Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.Q33319274
Phenotypic and molecular characterisation of Brucella isolates from marine mammalsQ33394024
The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogensQ33468439
Identification and characterization of the Brucella abortus phosphoglucomutase gene: role of lipopolysaccharide in virulence and intracellular multiplicationQ33591975
Regulation of Brucella abortus catalaseQ33595947
Identification of genes required for chronic persistence of Brucella abortus in miceQ33597577
Succinoglycan production by Rhizobium meliloti is regulated through the ExoS-ChvI two-component regulatory systemQ33721842
Molecular cloning and characterization of cgs, the Brucella abortus cyclic beta(1-2) glucan synthetase gene: genetic complementation of Rhizobium meliloti ndvB and Agrobacterium tumefaciens chvB mutants.Q33736391
Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survivalQ33751418
Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages.Q33752010
Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytesQ33768425
The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected miceQ33768886
Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment.Q33768984
Opsonized virulent Brucella abortus replicates within nonacidic, endoplasmic reticulum-negative, LAMP-1-positive phagosomes in human monocytesQ33788047
A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplicationQ33791293
The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c miceQ33867901
Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages.Q33868877
Brucella melitensis: a nasty bug with hidden credentials for virulenceQ33896055
Interruption of the cydB locus in Brucella abortus attenuates intracellular survival and virulence in the mouse model of infectionQ33995977
Genetic characterization of a Tn5-disrupted glycosyltransferase gene homolog in Brucella abortus and its effect on lipopolysaccharide composition and virulenceQ34001337
Brucella suis-impaired specific recognition of phagosomes by lysosomes due to phagosomal membrane modificationsQ34005721
Brucella abortus cyclic beta-1,2-glucan mutants have reduced virulence in mice and are defective in intracellular replication in HeLa cellsQ34008332
Ferrochelatase is present in Brucella abortus and is critical for its intracellular survival and virulenceQ34009336
The Brucella suis virB operon is induced intracellularly in macrophagesQ34010148
Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages.Q34033308
Identification of a new virulence factor, BvfA, in Brucella suis.Q34034020
Expression and role of superoxide dismutases (SOD) in pathogenic bacteriaQ34047487
Clinical recognition and management of patients exposed to biological warfare agentsQ34064997
Identification of a quorum-sensing signal molecule in the facultative intracellular pathogen Brucella melitensisQ34123343
A global pH sensor: Agrobacterium sensor protein ChvG regulates acid-inducible genes on its two chromosomes and Ti plasmid.Q34156123
Human Neurobrucellosis with Intracerebral Granuloma Caused by a Marine MammalBrucellasppQ34216012
Smooth and rough lipopolysaccharide phenotypes of Brucella induce different intracellular trafficking and cytokine/chemokine release in human monocytesQ34228588
The Brucella abortus xthA-1 gene product participates in base excision repair and resistance to oxidative killing but is not required for wild-type virulence in the mouse modelQ34353973
The evolution of chronic infection strategies in the alpha-proteobacteria.Q34369289
The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cellQ34389221
The sheathed flagellum of Brucella melitensis is involved in persistence in a murine model of infectionQ34412467
ppGpp: a global regulator in Escherichia coli.Q34415352
Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection.Q34491651
Brucella abortus synthesizes phosphatidylcholine from choline provided by the hostQ34509908
Brucella abortus 16S rRNA and lipid A reveal a phylogenetic relationship with members of the alpha-2 subdivision of the class ProteobacteriaQ34625645
Role of the Brucella suis lipopolysaccharide O antigen in phagosomal genesis and in inhibition of phagosome-lysosome fusion in murine macrophagesQ34714844
Deletion of znuA virulence factor attenuates Brucella abortus and confers protection against wild-type challengeQ34721093
Evaluation of protection afforded by Brucella abortus and Brucella melitensis unmarked deletion mutants exhibiting different rates of clearance in BALB/c miceQ34721256
Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells.Q34744746
Genetic organization and iron-responsive regulation of the Brucella abortus 2,3-dihydroxybenzoic acid biosynthesis operon, a cluster of genes required for wild-type virulence in pregnant cattleQ34853905
Production of the Siderophore 2,3-Dihydroxybenzoic Acid Is Required for Wild-Type Growth of Brucella abortus in the Presence of Erythritol under Low-Iron Conditions In VitroQ34932916
Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in miceQ34942704
Sugar metabolism by BrucellaeQ34987703
Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cellsQ35011151
Biosynthesis of phosphatidylcholine in bacteria.Q35053477
BrucellaStationary-Phase Gene Expression and VirulenceQ35121003
A B lymphocyte mitogen is a Brucella abortus virulence factor required for persistent infectionQ35133901
Protein synthesis in Brucella abortus induced during macrophage infection.Q35401784
Deletion of purE attenuates Brucella melitensis infection in miceQ35498593
Bacterial persistence and immunity in goats vaccinated with a purE deletion mutant or the parental 16M strain of Brucella melitensisQ35502485
A high-affinity cbb3-type cytochrome oxidase terminates the symbiosis-specific respiratory chain of Bradyrhizobium japonicumQ35603751
Rhizobium meliloti genes required for nodule development are related to chromosomal virulence genes in Agrobacterium tumefaciensQ35611494
FtcR is a new master regulator of the flagellar system of Brucella melitensis 16M with homologs in Rhizobiaceae.Q35634230
Different roles of the two high-oxygen-affinity terminal oxidases of Brucella suis: Cytochrome c oxidase, but not ubiquinol oxidase, is required for persistence in miceQ35688983
Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium.Q35689191
Controlling mRNA stability and translation with small, noncoding RNAsQ35737955
Adaptation of the Brucellae to their intracellular nicheQ35752932
Canine brucellosisQ35844332
Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensisQ35949935
Process of protein transport by the type III secretion systemQ35980175
Pathogenesis of abortion of bovine brucellosisQ40819907
A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suisQ40925092
Molecular basis of Brucella pathogenicity: an update.Q41080035
Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharidesQ41455142
Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxideQ41520592
The Lactobacillus anomaly: total iron abstinenceQ41576159
Effect of endocytic and metabolic inhibitors on the internalization and intracellular growth of Brucella abortus in Vero cellsQ41941535
NnrA is required for full virulence and regulates several Brucella melitensis denitrification genesQ41963970
Brucella suis prevents human dendritic cell maturation and antigen presentation through regulation of tumor necrosis factor alpha secretionQ42633862
Identification of sigma S-dependent genes associated with the stationary-phase acid-resistance phenotype of Shigella flexneriQ42642088
The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptidesQ42949034
Evaluation of a rough mutant of Brucella melitensis in pregnant goatsQ43677812
Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteriaQ44032829
Membrane sorting during swimming internalization of Brucella is required for phagosome trafficking decisionsQ44243223
Experimental infection of goat fetuses in utero with a stable, rough mutant of Brucella abortus.Q44621903
Superoxide dismutases of virulent and avirulent strains of Brucella abortusQ44943189
The defect in the metabolism of erythritol of the Brucella abortus B19 vaccine strain is unrelated with its attenuated virulence in miceQ45259196
Roles of Brucella abortus SpoT in morphological differentiation and intramacrophagic replicationQ46471498
A quorum-sensing regulator controls expression of both the type IV secretion system and the flagellar apparatus of Brucella melitensisQ46594076
Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence propertiesQ46765538
Functional genomic analysis of global regulator NolR in Sinorhizobium melilotiQ46944168
Role of HdeA in acid resistance and virulence in Brucella abortus 2308.Q47607049
A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence.Q47694537
Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival.Q47873772
The Brucella abortus host factor I (HF-I) protein contributes to stress resistance during stationary phase and is a major determinant of virulence in miceQ47910975
Phosphatidylcholine levels in Bradyrhizobium japonicum membranes are critical for an efficient symbiosis with the soybean host plantQ48375943
What is the nature of the replicative niche of a stealthy bug named Brucella?Q51670669
Protection of BALB/c mice against homologous and heterologous species of Brucella by rough strain vaccines derived from Brucella melitensis and Brucella suis biovar 4.Q52520303
The cytochrome bd quinol oxidase in Escherichia coli has an extremely high oxygen affinity and two oxygen-binding haems: implications for regulation of activity in vivo by oxygen inhibition.Q54590724
Extensive Cell Envelope Modulation Is Associated with Virulence inBrucella abortusQ57040895
Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortusQ57040915
Cyclic β-1,2-glucan is a brucella virulence factor required for intracellular survivalQ57040921
Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuoleQ57042065
Brucella abortus Lipopolysaccharide in Murine Peritoneal Macrophages Acts as a Down-Regulator of T Cell ActivationQ57042072
Lysosomal accumulation and recycling of lipopolysaccharide to the cell surface of murine macrophages, an in vitro and in vivo studyQ57042091
Brucella Intracellular Replication Requires Trafficking Through the Late Endosomal/Lysosomal CompartmentQ57662407
Fœtal Erythritol: A Cause of the Localization of Brucella Abortus in Bovine Contagious AbortionQ59097113
The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virBQ59259370
Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosisQ61052034
Importance of the Omp25/Omp31 family in the internalization and intracellular replication of virulent B. ovis in murine macrophages and HeLa cellsQ61278506
Bacterial survival, lymph node changes, and immunologic responses of cattle vaccinated with standard and mutant strains of Brucella abortusQ67957174
Entry and intracellular localization of Brucella spp. in Vero cells: fluorescence and electron microscopyQ68365222
Intracellular localization of Brucella abortus in bovine placentaQ69261494
Numbers of Brucella abortus in the placenta, umbilicus and fetal fluid of two naturally infected cowsQ71576339
Virulence of Agrobacterium tumefaciens requires phosphatidylcholine in the bacterial membraneQ79160737
Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strainQ79464603
Role of catalase in the virulence of Brucella melitensis in pregnant goatsQ80407367
Smooth Brucella strains invade and replicate in human lung epithelial cells without inducing cell deathQ83737669
P433issue4
P304page(s)221-238
P577publication date2009-09-22
P1433published inMedical Microbiology and ImmunologyQ15760239
P1476titleSurvival of the fittest: how Brucella strains adapt to their intracellular niche in the host
P478volume198

Reverse relations

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Q45091061The ferrous iron transporter FtrABCD is required for the virulence of Brucella abortus 2308 in mice
Q38631036The iron-responsive regulator irr is required for wild-type expression of the gene encoding the heme transporter BhuA in Brucella abortus 2308.
Q54441778The two-component systems PrrBA and NtrYX co-ordinately regulate the adaptation of Brucella abortus to an oxygen-limited environment.
Q38714536Transcriptional regulator GntR of Brucella abortus regulates cytotoxicity, induces the secretion of inflammatory cytokines and affects expression of the type IV secretion system and quorum sensing system in macrophages
Q64263078Transcriptomic Analysis of the Brucella melitensis Rev.1 Vaccine Strain in an Acidic Environment: Insights Into Virulence Attenuation

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