Role of the innate immune system in the pathogenesis of multiple sclerosis

scientific article

Role of the innate immune system in the pathogenesis of multiple sclerosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.JNEUROIM.2009.10.015
P932PMC publication ID2854189
P698PubMed publication ID19931190
P5875ResearchGate publication ID40024619

P50authorHoward L. WeinerQ20985921
P2093author name stringAlice Laroni
Roopali Gandhi
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Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cellsQ24675226
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Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosisQ36375991
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The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous systemQ48554549
Mast cells in plaques of multiple sclerosisQ48609684
Peripheral blood ?-? T cells lyse fresh human brain?Derived oligodendrocytesQ48613619
Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesisQ48652496
Cortical demyelination and diffuse white matter injury in multiple sclerosis.Q48726181
Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injuryQ48822291
Identification of IgE-positive cells and mast cells in frozen sections of multiple sclerosis brainsQ48846971
Mast cell activation by myelin through scavenger receptorQ49034996
A role for natural killer cells in the immunopathogenesis of multiple sclerosis.Q50876710
Differentiation of human NK cells into NK1 and NK2 subsets.Q52036591
NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis.Q52576677
Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells.Q52937746
CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE.Q53015646
Correlation of specialized CD16(+) gammadelta T cells with disease course and severity in multiple sclerosis.Q54269703
Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis.Q54523448
Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responsesQ56988858
Innate immune-mediated neuronal injury consequent to loss of astrocytesQ57041709
Immunity or tolerance? That is the question for dendritic cellsQ57227901
Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokinesQ62065049
A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouseQ71384783
Gamma delta T cell receptor variable region usage during the development of experimental allergic encephalomyelitisQ71586060
Synergistic action of estradiol and myelin basic protein on mast cell secretion and brain myelin changes resembling early stages of demyelinationQ71610031
Aggravation of murine experimental allergic encephalomyelitis by administration of T-cell receptor gammadelta-specific antibodyQ73128587
NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic toleranceQ73311779
Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V alpha 14 NK T cellsQ73311971
Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gammaQ73540137
Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathyQ73644565
Cytokines: influence on glial cell gene expression and functionQ73837328
Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivoQ77323598
Experimental autoimmune encephalomyelitis induction in naive mice by dendritic cells presenting a self-peptideQ77703439
Mature bone marrow-derived dendritic cells polarize Th2 response and suppress experimental autoimmune encephalomyelitisQ78637162
Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remissionQ78961005
Clinical relapses of multiple sclerosis are associated with 'novel' valleys in natural killer cell functional activityQ79329740
Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivoQ79929612
Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells.Q46078718
A pilot, open label, clinical trial using hydroxyzine in multiple sclerosisQ46875995
Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosisQ46973046
The regulatory role of natural killer cells in multiple sclerosisQ47260618
Gammadelta T cells enhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 productionQ47309507
FcgammaRIII discriminates between 2 subsets of Vgamma9Vdelta2 effector cells with different responses and activation pathways.Q47391978
Mast Cells Exert Effects Outside the Central Nervous System to Influence Experimental Allergic Encephalomyelitis Disease CourseQ47581695
Mechanism of gammadelta T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosisQ47817717
The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptorsQ47871181
The effect of gammadelta T cell depletion on cytokine gene expression in experimental allergic encephalomyelitis.Q47936770
Role of natural killer cells and TCR gamma delta T cells in acute autoimmune encephalomyelitisQ48035765
Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements.Q48074043
Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitisQ48100149
Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis.Q48176320
Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitisQ48218333
The multitasking mast cell: positive and negative roles in the progression of autoimmunityQ36914685
Mitomycin C-treated dendritic cells inactivate autoreactive T cells: toward the development of a tolerogenic vaccine in autoimmune diseasesQ36976323
Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognitionQ37001277
Cutting edge: the mechanism of invariant NKT cell responses to viral danger signalsQ37003800
Toll-like receptors in defense and damage of the central nervous systemQ37015536
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferiQ37018981
Role of natural killer cells in the pathogenesis and progression of multiple sclerosisQ37053278
A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosisQ37101287
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosisQ37121507
Induction and effector functions of T(H)17 cells.Q37194494
Microglial clearance function in health and diseaseQ37222916
Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosisQ37243469
Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cellsQ37313533
NK cells and Treg cells: a fascinating dance cheek to cheekQ37315670
Regulation of autoimmune encephalomyelitis by toll-like receptorsQ37390942
The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?Q37427659
Protective effects of microglia in multiple sclerosis.Q37467153
Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosisQ37555960
Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.Q38495710
Characterization and distribution of lymphocyte subpopulations in multiple sclerosis plaques versus autoimmune demyelinating lesionsQ39821466
Production and functions of IL-17 in microgliaQ40029522
Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.Q40453661
Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand.Q40460778
Characterization of human blood dendritic cell subsetsQ40625943
Neuroprotection by encephalomyelitis: rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells.Q40869638
Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain geneQ40911408
Targeting of human dendritic cells by autologous NK cells.Q40914002
Mast cells in the brain: evidence and functional significance.Q41095954
gamma delta T-cell-human glial cell interactions. II. Relationship between heat shock protein expression and susceptibility to cytolysisQ41119043
gamma delta T-cell-human glial cell interactions. I. In vitro induction of gammadelta T-cell expansion by human glial cellsQ41119050
Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cellsQ41139248
Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity.Q41985283
Reciprocal activating interaction between natural killer cells and dendritic cellsQ41992239
Contact-dependent stimulation and inhibition of dendritic cells by natural killer cellsQ42005335
Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patientsQ42280284
Th1 polarization of CD4+ T cells by Toll-like receptor 3-activated human microglia.Q42518403
Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subsetQ43600819
The role of mast cells in demyelination. 1. Myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulationQ43819984
CD4+, CD8+, and CD4- CD8- T cells in CSF and blood of patients with multiple sclerosis and tension headacheQ44262356
Broad expression of Toll-like receptors in the human central nervous systemQ44492400
Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitisQ44701314
Cytokines in the central nervous system of mice during chronic relapsing experimental allergic encephalomyelitisQ44820890
The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cellsQ44910149
Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severityQ44916817
Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected miceQ45740050
Natural history of multiple sclerosis in a population-based cohortQ45767634
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectpathogenesisQ372016
multiple sclerosisQ8277
P304page(s)7-14
P577publication date2010-04-01
P1433published inJournal of NeuroimmunologyQ15716691
P1476titleRole of the innate immune system in the pathogenesis of multiple sclerosis
P478volume221

Reverse relations

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