Toll-like receptors are key players in neurodegeneration

scientific article published on 25 May 2011

Toll-like receptors are key players in neurodegeneration is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.INTIMP.2011.05.006
P8608Fatcat IDrelease_ru5kxhj65jhbhaz2howzkz4jrq
P932PMC publication ID3183240
P698PubMed publication ID21616174
P5875ResearchGate publication ID51168724

P2093author name stringPablo Iribarren
Maria C Rodriguez-Galan
Daniela S Arroyo
Emilia A Gaviglio
Javier A Soria
P2860cites workMicroglia initiate central nervous system innate and adaptive immune responses through multiple TLRsQ24303416
What the Myddosome structure tells us about the initiation of innate immunityQ24338472
Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosisQ24645038
Does neuroinflammation fan the flame in neurodegenerative diseases?Q27498993
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsQ27860900
Pathogen recognition and innate immunityQ27861084
Alzheimer's disease: genes, proteins, and therapyQ28131806
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-betaQ28506630
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptorsQ28511605
Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitisQ28591514
Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1Q28646121
Microglia-mediated neurotoxicity: uncovering the molecular mechanismsQ29547835
Recognition of microorganisms and activation of the immune responseQ29617903
Mechanisms underlying inflammation in neurodegenerationQ29617977
Microglial cells in astroglial cultures: a cautionary noteQ30480840
Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brainQ30665189
Insights into the neurodegenerative process of Alzheimer's disease: a role for mononuclear phagocyte-associated inflammation and neurotoxicityQ33594690
Inflammation, microglia, and Alzheimer's diseaseQ33664099
Role of the innate immune system in the pathogenesis of multiple sclerosisQ33787624
Resveratrol differentially modulates inflammatory responses of microglia and astrocytesQ34114119
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.Q34160547
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosisQ34312767
The pathogenesis of senile plaquesQ34421483
SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.Q39725027
An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.Q39826521
Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide.Q40341534
Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferonQ40368047
A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.Q40657503
Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells.Q40761654
MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease.Q42026763
Preferential expression and function of Toll-like receptor 3 in human astrocytesQ42472896
Broad expression of Toll-like receptors in the human central nervous systemQ44492400
Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines.Q45269970
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's diseaseQ45877904
Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytesQ46654805
Cultured astrocytes express toll-like receptors for bacterial productsQ48235492
What is immune privilege (not)?Q48356667
Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseasesQ48459159
The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS.Q48529344
Cortical demyelination and diffuse white matter injury in multiple sclerosis.Q48726181
Viruses selectively upregulate Toll-like receptors in the central nervous systemQ48771055
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.Q51817662
In response to pathogens, glial cells dynamically and differentially regulate Toll-like receptor gene expression.Q54644936
Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous systemQ61709654
Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-betaQ79370162
A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivityQ79931398
CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2Q81341065
Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing--remitting experimental autoimmune encephalomyelitisQ81342560
IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microgliaQ81375625
The role of dendritic cells in neurodegenerative diseases.Q34721462
Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathologyQ34943311
Microglia as neuroprotective, immunocompetent cells of the CNS.Q34963638
Microglia as a source and target of cytokinesQ34963658
Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2.Q34975805
Toll-like receptor 3 is a potent negative regulator of axonal growth in mammalsQ35037100
TLR8: an innate immune receptor in brain, neurons and axonsQ35047901
The Toll-IL-1 receptor adaptor family grows to five members.Q35155932
The Increasing Burden of Alzheimer DiseaseQ35544971
Expression and distribution of Toll-like receptors in the brain during murine neurocysticercosisQ35606759
Multiple sclerosis is an inflammatory T-cell-mediated autoimmune diseaseQ35914863
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficitsQ35963056
Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia.Q36008864
Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral responseQ36098825
Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer diseaseQ36124489
How Toll-like receptors signal: what we know and what we don't knowQ36339101
The role of inflammation in CNS injury and diseaseQ36364424
Glial toll-like receptor signaling in central nervous system infection and autoimmunityQ36440629
The role of Toll-like receptors in CNS response to microbial challengeQ36561142
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activitiesQ36689365
Role of toll-like receptor signalling in Abeta uptake and clearanceQ36745996
Toll-like receptors in inflammation, infection and cancerQ36900602
Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferationQ37088433
Can the immune system be harnessed to repair the CNS?Q37168160
Toll-like receptors in neurodegeneration.Q37186287
How location governs toll-like receptor signalingQ37341616
Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.Q37352700
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.Q37424811
Unique lipids from a common human bacterium represent a new class of Toll-like receptor 2 ligands capable of enhancing autoimmunityQ37462735
Regulation of innate immune responses in the brainQ37492253
A cell biological view of Toll-like receptor function: regulation through compartmentalization.Q37531879
Inflammation and microglia actions in Alzheimer's diseaseQ37577745
Orchestrating innate immune responses in multiple sclerosis: molecular players.Q37764110
Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic applicationQ37779740
Evaluating the role of Toll-like receptors in diseases of the central nervous systemQ37829488
P433issue10
P921main subjecttoll-like receptorQ408004
neurodegenerationQ1755122
P304page(s)1415-1421
P577publication date2011-05-25
P1433published inInternational ImmunopharmacologyQ15751306
P1476titleToll-like receptors are key players in neurodegeneration
P478volume11

Reverse relations

cites work (P2860)
Q35837175ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila
Q33563621Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration
Q38164897Autophagy in inflammation, infection, neurodegeneration and cancer
Q48490461Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats
Q34680801Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target.
Q37656512Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes
Q59806693Curative Anti-Inflammatory Properties of Chinese Optimized Yinxieling Formula in Models of Parkinson's Disease
Q35227177Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction.
Q44580754Drosophila innate immune response pathways moonlight in neurodegeneration
Q64118947Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study
Q47836666Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression Profiles
Q36164195Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
Q35544629Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signaling
Q44064986Increased expression of toll-like receptor 4 on neurons after surgery in aged rats.
Q47270261Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance
Q38698825Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
Q34243536Mechanically-compliant intracortical implants reduce the neuroinflammatory response.
Q47767037Nalmefene Prevents Alcohol-Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4.
Q35178233Neuropeptides and the microbiota-gut-brain axis
Q37019818Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation
Q61855781Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture
Q39123617RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
Q39105980Sterile Neuroinflammation and Strategies for Therapeutic Intervention
Q64077495Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes
Q38031912Targeting neuroinflammation for therapeutic intervention in neurodegenerative pathologies: a role for the peptide analogue of thymulin (PAT).
Q88197650The Potential Role of Toll-Like Receptor 4 in Mediating Dopaminergic Cell Loss and Alpha-Synuclein Expression in the Acute MPTP Mouse Model of Parkinson's Disease
Q38348923The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.
Q58780967The Role of Toll-Like Receptor 2 and 4 Innate Immunity Pathways in Intracortical Microelectrode-Induced Neuroinflammation
Q38670012The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease
Q38156518The influence of cannabinoids on generic traits of neurodegeneration
Q38162221The innate immune system in Alzheimer's disease.
Q37010253The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE.
Q47575333Toll-Like Receptor-3 Mediates HIV-1-Induced Interleukin-6 Expression in the Human Brain Endothelium via TAK1 and JNK Pathways: Implications for Viral Neuropathogenesis.
Q36482922Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy
Q34094965Toll-like receptor 4-mediated signaling participates in apoptosis of hippocampal neurons
Q36960922Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication
Q54544299Toll-like receptors and diseases.
Q53687316Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.
Q64961502Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes.

Search more.