Molecular mechanisms of varicella zoster virus pathogenesis

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Molecular mechanisms of varicella zoster virus pathogenesis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1050899746
P356DOI10.1038/NRMICRO3215
P932PMC publication ID4066823
P698PubMed publication ID24509782
P5875ResearchGate publication ID260130850

P50authorAnn ArvinQ4766238
Leigh ZerboniQ130280462
P2093author name stringStefan L Oliver
Nandini Sen
P2860cites workPML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteinsQ24683226
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Varicella-zoster virus ORF63 inhibits apoptosis of primary human neuronsQ43181854
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Varicella-zoster virus gE escape mutant VZV-MSP exhibits an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice.Q30657750
Laser-capture microdissection: refining estimates of the quantity and distribution of latent herpes simplex virus 1 and varicella-zoster virus DNA in human trigeminal Ganglia at the single-cell levelQ33226129
Anti-glycoprotein H antibody impairs the pathogenicity of varicella-zoster virus in skin xenografts in the SCID mouse modelQ33558564
Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccineQ33585318
Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infectionQ33591823
Insulin degrading enzyme induces a conformational change in varicella-zoster virus gE, and enhances virus infectivity and stabilityQ33622464
Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesvirusesQ33640129
Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infectionQ33769405
Varicella-zoster virus infection of human dorsal root ganglia in vivo.Q33772101
Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virusQ33815559
Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal gangliaQ33825691
Varicella-zoster virus T cell tropism and the pathogenesis of skin infectionQ33828495
The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3Q33828713
Virion association of IE62, the varicella-zoster virus (VZV) major transcriptional regulatory protein, requires expression of the VZV open reading frame 66 protein kinaseQ33845364
Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virusQ33853728
Disruption of PML nuclear bodies is mediated by ORF61 SUMO-interacting motifs and required for varicella-zoster virus pathogenesis in skinQ34013598
T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infectionQ34045556
Characterization of the host immune response in human Ganglia after herpes zoster.Q34055440
Attenuation of the vaccine Oka strain of varicella-zoster virus and role of glycoprotein C in alphaherpesvirus virulence demonstrated in the SCID-hu mouseQ34069075
VZV molecular epidemiologyQ34103953
Varicella-zoster virus immediate-early protein 62 blocks interferon regulatory factor 3 (IRF3) phosphorylation at key serine residues: a novel mechanism of IRF3 inhibition among herpesvirusesQ34120083
ORF7 of varicella-zoster virus is a neurotropic factorQ34295291
Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zosterQ34379873
Varicella-zoster virus glycoprotein E is a critical determinant of virulence in the SCID mouse-human model of neuropathogenesisQ34457924
Upregulation of CXCL10 in human dorsal root ganglia during experimental and natural varicella-zoster virus infection.Q34457932
Molecular characterization of varicella zoster virus in latently infected human ganglia: physical state and abundance of VZV DNA, Quantitation of viral transcripts and detection of VZV-specific proteinsQ34470460
Downregulation of varicella-zoster virus (VZV) immediate-early ORF62 transcription by VZV ORF63 correlates with virus replication in vitro and with latencyQ34545582
Varicella-zoster virus open reading frame 10 is a virulence determinant in skin cells but not in T cells in vivoQ34545651
Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo.Q34648184
Varicella-zoster virus transcriptome in latently infected human gangliaQ34741852
Varicella zoster disease of the central nervous system: epidemiological, clinical, and laboratory features 10 years after the introduction of the varicella vaccineQ34763836
Simian varicella virus pathogenesisQ34792668
Differentiation of varicella-zoster virus ORF47 protein kinase and IE62 protein binding domains and their contributions to replication in human skin xenografts in the SCID-hu mouseQ34976977
Construction of varicella-zoster virus recombinants from parent Oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse modelQ34977139
Mutational Analysis of Open Reading Frames 62 and 71, Encoding the Varicella-Zoster Virus Immediate-Early Transactivating Protein, IE62, and Effects on Replication In Vitro and in Skin Xenografts in the SCID-hu Mouse In VivoQ34977329
Mutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cellsQ35076854
ORF66 protein kinase function is required for T-cell tropism of varicella-zoster virus in vivoQ35139995
The immediate-early 63 protein of Varicella-Zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo.Q35543796
Structure-function analysis of varicella-zoster virus glycoprotein H identifies domain-specific roles for fusion and skin tropismQ35546891
Apparent expression of varicella-zoster virus proteins in latency resulting from reactivity of murine and rabbit antibodies with human blood group a determinants in sensory neuronsQ35666116
Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesisQ35673818
Varicella-Zoster virus ORF12 protein triggers phosphorylation of ERK1/2 and inhibits apoptosisQ35826325
The varicella-zoster virus (VZV) open reading frame 47 (ORF47) protein kinase is dispensable for viral replication and is not required for phosphorylation of ORF63 protein, the VZV homolog of herpes simplex virus ICP22.Q35851574
Varicella zoster virus (VZV) infects and establishes latency in enteric neuronsQ35883027
Varicella-Zoster virus IE63, a major viral latency protein, is required to inhibit the alpha interferon-induced antiviral responseQ35947547
Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia in vivo in the absence of glycoprotein I.Q35956960
Cellular and viral factors regulate the varicella-zoster virus gE promoter during viral replicationQ36099097
The varicella-zoster virus genomeQ36145800
The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouseQ36327713
Varicella-zoster virus transfer to skin by T Cells and modulation of viral replication by epidermal cell interferon-alphaQ36403830
Generation of varicella-zoster virus (VZV) and viral mutants from cosmid DNAs: VZV thymidylate synthetase is not essential for replication in vitroQ36465730
Aberrant intracellular localization of Varicella-Zoster virus regulatory proteins during latencyQ36507994
Varicella-zoster virus ORF12 protein activates the phosphatidylinositol 3-kinase/Akt pathway to regulate cell cycle progressionQ36559931
An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesisQ36583285
T-cell infiltration correlates with CXCL10 expression in ganglia of cynomolgus macaques with reactivated simian varicella virusQ36607066
Herpes simplex virus 1 tropism for human sensory ganglion neurons in the severe combined immunodeficiency mouse model of neuropathogenesisQ36607105
Investigation of varicella-zoster virus infection of lymphocytes by in situ hybridizationQ36827734
Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activationQ36994683
Deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein E ectodomain abolishes the gE and gI interaction and differentially affects cell-cell spread and viral entryQ37033241
Regulation of the ORF61 promoter and ORF61 functions in varicella-zoster virus replication and pathogenesisQ37256702
Differential requirement for cell fusion and virion formation in the pathogenesis of varicella-zoster virus infection in skin and T cellsQ37596465
Functions of the C-terminal domain of varicella-zoster virus glycoprotein E in viral replication in vitro and skin and T-cell tropism in vivoQ37596576
Varicella zoster virus immune evasion strategies.Q37606051
Varicella-zoster virus open reading frame 66 protein kinase and its relationship to alphaherpesvirus US3 kinasesQ37606637
Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal modelsQ37625435
Overview of varicella-zoster virus glycoproteins gC, gH and gL.Q37699016
Varicella-zoster virus vaccine: molecular geneticsQ37708081
VZV infection of keratinocytes: production of cell-free infectious virions in vivoQ37708084
Varicella-zoster virus neurotropism in SCID mouse-human dorsal root ganglia xenograftsQ37708087
Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neuronsQ37710719
Experimental models to study varicella-zoster virus infection of neurons.Q37725733
Roles of cellular transcription factors in VZV replicationQ37758510
Autophagosome formation during varicella-zoster virus infection following endoplasmic reticulum stress and the unfolded protein responseQ38286153
Characterization of interaction of gH and gL glycoproteins of varicella-zoster virus: their processing and traffickingQ38312235
Functions of the ORF9-to-ORF12 gene cluster in varicella-zoster virus replication and in the pathogenesis of skin infectionQ38609902
ORF11 protein interacts with the ORF9 essential tegument protein in varicella-zoster virus infectionQ39191152
Essential role played by the C-terminal domain of glycoprotein I in envelopment of varicella-zoster virus in the trans-Golgi network: interactions of glycoproteins with tegumentQ39601211
Varicella-zoster virus infection of human dendritic cells and transmission to T cells: implications for virus dissemination in the hostQ39603314
Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markersQ39685893
Promoter sequences of varicella-zoster virus glycoprotein I targeted by cellular transactivating factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivoQ39698466
Glycoprotein I of varicella-zoster virus is required for viral replication in skin and T cellsQ39753125
Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are essential for viral replication, and the furin cleavage motif contributes to pathogenesis in skin tissue in vivoQ39846393
Mutational analysis of the role of glycoprotein I in varicella-zoster virus replication and its effects on glycoprotein E conformation and traffickingQ39882103
Functions of Varicella-zoster virus ORF23 capsid protein in viral replication and the pathogenesis of skin infectionQ39953349
A self-excisable infectious bacterial artificial chromosome clone of varicella-zoster virus allows analysis of the essential tegument protein encoded by ORF9.Q40072508
Downregulation of class I major histocompatibility complex surface expression by varicella-zoster virus involves open reading frame 66 protein kinase-dependent and -independent mechanisms.Q40120151
Perspectives on vaccines against varicella-zoster virus infectionsQ40363716
Cell-type-dependent activation of the cellular EF-1alpha promoter by the varicella-zoster virus IE63 proteinQ40413345
Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu miceQ40444868
Varicella-zoster virus DNA in human sensory gangliaQ41558362
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpathogenesisQ372016
P304page(s)197-210
P577publication date2014-02-10
P1433published inNature Reviews MicrobiologyQ1071797
P1476titleMolecular mechanisms of varicella zoster virus pathogenesis
P478volume12