Aquaporins: important but elusive drug targets.

scientific article

Aquaporins: important but elusive drug targets. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/NRD4226
P932PMC publication ID4067137
P698PubMed publication ID24625825
P5875ResearchGate publication ID260808559

P50authorMarios PapadopoulosQ71323892
Alan S VerkmanQ88739484
P2093author name stringMarc O Anderson
P2860cites workRelative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAGQ24319156
Aquaporin-1 transports NO across cell membranesQ24336218
Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumabQ24598109
Aquaporin 4 and neuromyelitis opticaQ24613666
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.Q24631193
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channelQ24646531
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductanceQ24648744
Structural determinants of water permeation through aquaporin-1Q27627493
Structure of a glycerol-conducting channel and the basis for its selectivityQ27627520
Structural basis of water-specific transport through the AQP1 water channelQ27637193
Crystal Structure of a Yeast Aquaporin at 1.15 Å Reveals a Novel Gating MechanismQ27655977
ZINC--a free database of commercially available compounds for virtual screeningQ27656255
Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice.Q27863378
Functional and molecular characterization of the human neutral solute channel aquaporin-9.Q27876218
Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporinQ27919626
Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 proteinQ27919643
Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers.Q27919685
Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protonsQ27919687
Identification of arylsulfonamides as Aquaporin 4 inhibitorsQ27919706
Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutantsQ28115855
Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urineQ28118727
Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12qQ28143937
The barrier for proton transport in aquaporins as a challenge for electrostatic models: the role of protein relaxation in mutational calculationsQ36508923
Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody.Q36596808
Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assemblyQ36650382
Aquaporins--new players in cancer biologyQ36661699
Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissuesQ36674076
Aquaporins and cell migration.Q36677150
Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinaseQ36852554
AqF026 is a pharmacologic agonist of the water channel aquaporin-1.Q36977371
Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutationQ37072437
Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null miceQ37089696
Membrane proteins: molecular dynamics simulations.Q37136274
Congenital nephrogenic diabetes insipidus: what can we learn from mouse models?Q37268479
Dynamics and energetics of permeation through aquaporins. What do we learn from molecular dynamics simulations?Q37354955
Role of aquaporin-7 and aquaporin-9 in glycerol metabolism; involvement in obesityQ37354987
Structural function of MIP/aquaporin 0 in the eye lens; genetic defects lead to congenital inherited cataractsQ37354994
Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.Q37371413
Is TEA an inhibitor for human Aquaporin-1?Q37373374
Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperonesQ37382192
Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemiaQ37503646
Aquaporin-1 gene deletion reduces breast tumor growth and lung metastasis in tumor-producing MMTV-PyVT miceQ37593972
Aquaglyceroporin 9 in brain pathologiesQ37619778
Structural insights into eukaryotic aquaporin regulation.Q37736656
Congenital nephrogenic diabetes insipidus: the current state of affairsQ37994652
A practical guide to the treatment of neuromyelitis opticaQ38032533
Noble metal-dithiocarbamates precious allies in the fight against cancer.Q38038919
Aquaporin 2: from its discovery to molecular structure and medical implicationsQ38053222
A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compoundsQ38162354
AQP3 deficiency in humans and the molecular basis of a novel blood group system, GILQ28202621
New roles for old holes: ion channel function in aquaporin-1Q28209387
Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healingQ28255260
Disease amelioration with tocilizumab in a treatment-resistant patient with neuromyelitis optica: implication for cellular immune responsesQ28289228
Inhibition of aquaporin-1 water permeability by tetraethylammonium: involvement of the loop E pore regionQ28377529
Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compoundQ28483815
Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neuronsQ28504662
Localization of aquaporin-5 in sweat glands and functional analysis using knockout miceQ28504990
Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null miceQ28505909
Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubuleQ28507564
Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid productionQ28584934
Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channelsQ28585485
Impaired hearing in mice lacking aquaporin-4 water channelsQ28585889
Impaired pain sensation in mice lacking Aquaporin-1 water channelsQ28586073
Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channelsQ28587119
Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa rectaQ28588644
Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of ratQ28640264
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosisQ29615952
Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma.Q30351899
Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs.Q30403317
Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imagingQ30488992
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuoleQ30495595
Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitationQ30531303
Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytesQ30572079
Green fluorescent protein-based halide indicators with improved chloride and iodide affinitiesQ30993765
The spectrum of neuromyelitis opticaQ31122077
Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1.Q33234020
Hereditary polyuric disorders: new concepts and differential diagnosis.Q33244158
Automated cell-based assay for screening of aquaporin inhibitors.Q33496547
Nitric oxide conduction by the brain aquaporin AQP4.Q33587709
Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neuronsQ33648573
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.Q33656297
Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhageQ33781427
Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinaseQ33911541
Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulenceQ35928017
Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitisQ36172664
Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null miceQ36272820
Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptakeQ36278017
Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cordQ36328228
Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.Q36347957
Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruptionQ36421132
Plasma membrane water permeability of cultured cells and epithelia measured by light microscopy with spatial filteringQ36435887
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunctionQ36436807
Discovery of novel human aquaporin-1 blockersQ48313729
Homozygosity for aquaporin 7 G264V in three unrelated children with hyperglyceroluria and a mild platelet secretion defect.Q48641894
Water flux through human aquaporin 1: inhibition by intracellular furosemide and maximal response with high osmotic gradients.Q48680234
Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.Q48823528
The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.Q49155866
Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action.Q50114413
Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess.Q50482942
Water transport by GLUT2 expressed in Xenopus laevis oocytes.Q50641800
Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes.Q51350578
Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer.Q54429014
Physiology and pathophysiology of renal aquaporinsQ55895175
Inhibition of water and solute permeability in human red cellsQ71570903
Membrane stress causes inhibition of water channels in brush border membrane vesicles from kidney proximal tubuleQ74192842
Evidence for the presence of aquaporin-3 in human red blood cellsQ74392991
Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranesQ79359469
Downregulation in aquaporin 4 and aquaporin 8 expression of the colon associated with the induction of allergic diarrhea in a mouse model of food allergyQ80490457
Novel therapeutic targets in Plasmodium falciparum: aquaglyceroporinsQ83588843
Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis opticaQ38429895
The identification of novel, high affinity AQP9 inhibitors in an intracellular binding siteQ39187334
Aquaporin 2-increased renal cell proliferation is associated with cell volume regulation.Q39316213
Functional characterization of three aquaglyceroporins from Trypanosoma brucei in osmoregulation and glycerol transport.Q39562891
Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodiesQ39881740
Increased migration and metastatic potential of tumor cells expressing aquaporin water channelsQ40259967
Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4.Q41104307
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.Q41717152
Skeletal muscle function and water permeability in aquaporin-4 deficient miceQ41739195
Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5.Q41743737
Human AQP1 is a constitutively open channel that closes by a membrane-tension-mediated mechanismQ41763722
Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferationQ41946016
In silico study of Aquaporin V: Effects and affinity of the central pore-occluding lipidQ42013859
Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminaeQ42455897
A cautionary note on cosmetics containing ingredients that increase aquaporin-3 expressionQ42525310
A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28kQ42558820
Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding siteQ43106571
Increased aquaporin 1 water channel expression in human brain tumours.Q43202899
Potential utility of aquaporin modulators for therapy of brain disordersQ43225155
Involvement of aquaporin-4 in astroglial cell migration and glial scar formationQ43406920
Aquaporin-5 dependent fluid secretion in airway submucosal glandsQ43714156
Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitisQ43836570
Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channelsQ43871295
Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3.Q43906941
New potent inhibitors of aquaporins: silver and gold compounds inhibit aquaporins of plant and human originQ44219171
K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator.Q44390087
Mutation in AQP5, encoding aquaporin 5, causes palmoplantar keratoderma Bothnia typeQ44592425
Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte.Q44712521
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice.Q45060496
Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulationQ45299300
Aquaporin inhibition by gold(III) compounds: new insightsQ45734517
Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells.Q45923817
Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels.Q46024174
Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B.Q46047959
Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injuryQ46072044
Expression of aquaporin water channels in mouse spinal cordQ46080797
Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidusQ46154764
Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1.Q46441128
Protective role of aquaporin-4 water channels after contusion spinal cord injuryQ46486212
Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelializationQ46519526
NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytesQ46575811
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption.Q46588165
Functional characterization of the Escherichia coli glycerol facilitator, GlpF, in Xenopus oocytesQ46605935
Correlation between serum thyroxine and complements in patients with multiple sclerosis and neuromyelitis optica.Q46651305
Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema.Q46651668
Defective macrophage function in aquaporin-3 deficiencyQ46767021
Inhibition of aquaporin 4 by antiepileptic drugsQ46820895
Epinephrine stimulates fluid absorption across bovine retinal pigment epitheliumQ46911738
Membrane tension regulates water transport in yeastQ47396378
Hydrating skin by stimulating biosynthesis of aquaporins.Q47870679
Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomasQ48129721
Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics.Q33942796
Cell volume and plasma membrane osmotic water permeability in epithelial cell layers measured by interferometryQ34041394
Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in miceQ34073957
Defective urinary concentrating ability due to a complete deficiency of aquaporin-1.Q34084476
Aquaporin-5: a marker protein for proliferation and migration of human breast cancer cellsQ34092521
Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signalingQ34115487
Cell volume measured by total internal reflection microfluorimetry: application to water and solute transport in cells transfected with water channel homologsQ34129275
Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.Q34154265
Neuromyelitis optica IgG causes placental inflammation and fetal death.Q34168084
What really prevents proton transport through aquaporin? Charge self-energy versus proton wire proposalsQ34183919
Aquaporin Z of Escherichia coli: reassessment of its regulation and physiological roleQ34315864
Expression of mRNA coding for kidney and red cell water channels in Xenopus oocytesQ34364114
The dynamics and energetics of water permeation and proton exclusion in aquaporinsQ34412160
Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50.Q34440215
AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glandsQ34462173
Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching methodQ34542751
Origins of proton transport behavior from selectivity domain mutations of the aquaporin-1 channelQ34547035
The structure of aquaporinsQ34589055
Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.Q34621516
Expression of the water channel protein aquaporin-9 in malignant brain tumorsQ34631619
The gating mechanism of the human aquaporin 5 revealed by molecular dynamics simulationsQ34658040
The structural basis of water permeation and proton exclusion in aquaporinsQ34665542
A small molecule screen identifies selective inhibitors of urea transporter UT-A.Q34993481
Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus.Q35149581
Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient miceQ35163727
Aquaporin-4 expression is increased in oedematous human brain tumours.Q35465645
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeetQ35471502
Hyperosmotic stress induces aquaporin-dependent cell shrinkage, polyphosphate synthesis, amino acid accumulation, and global gene expression changes in Trypanosoma cruzi.Q35626082
Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimerasQ35647380
Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels.Q35683766
Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytesQ35708842
Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.Q35857869
Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arraysQ35922319
P433issue4
P304page(s)259-277
P577publication date2014-03-14
P1433published inNature Reviews Drug DiscoveryQ45998
P1476titleAquaporins: important but elusive drug targets
P478volume13

Reverse relations

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Q92309644Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors
Q35898207Identification of Estrogen Response Element in Aquaporin-3 Gene that Mediates Estrogen-induced Cell Migration and Invasion in Estrogen Receptor-positive Breast Cancer
Q47192132Immunopathogenesis in Myasthenia Gravis and Neuromyelitis Optica
Q47733635Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways.
Q101476064Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
Q64103262Inhibitors of Mammalian Aquaporin Water Channels
Q92157963Insights into the pathogenesis of cystoid macular edema: leukostasis and related cytokines
Q38704738Involvement of ion channels and transporters in carcinoma angiogenesis and metastasis.
Q48512571Lipodisks integrated with weak affinity chromatography enable fragment screening of integral membrane proteins.
Q83225749Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry
Q64107122Low temperature-induced variation in plasma biochemical indices and aquaglyceroporin gene expression in the large yellow croaker Larimichthys crocea
Q42502428MDCK cells are capable of water secretion and reabsorption in response to changes in the ionic environment
Q50459210Mechanical Characterization of Microengineered Epithelial Cysts by Using Atomic Force Microscopy.
Q49713173Mechanisms for lesion localization in neuromyelitis optica spectrum disorders.
Q55265662Mechanisms of Aquaporin-Facilitated Cancer Invasion and Metastasis.
Q51112277Methods to Measure Water Permeability.
Q36276284Microfluidic platform for rapid measurement of transepithelial water transport.
Q59792314Molecular Basis of Aquaporin-7 Permeability Regulation by pH
Q98291777Molecular Dynamics Simulations of Mite Aquaporin DerfAQP1 from the Dust Mite Dermatophagoides farinae (Acariformes: Pyroglyphidae)
Q90903674Molecular Mechanism of T-2 Toxin-Induced Cerebral Edema by Aquaporin-4 Blocking and Permeation
Q100533677NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer's disease
Q51656629Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells.
Q92854273Neuromyelitis Optica Spectrum Disorder and Anti-MOG Syndromes
Q30975717Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin-4 channelopathies: a decade later
Q55692261Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs.
Q35719719Opposing Effects of cAMP and T259 Phosphorylation on Plasma Membrane Diffusion of the Water Channel Aquaporin-5 in Madin-Darby Canine Kidney Cells
Q55147402Oriented chiral water wires in artificial transmembrane channels.
Q58802958Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain
Q37376760Oxygen-dependent regulation of aquaporin-3 expression
Q52575777Pancreatic Aquaporin-7: A Novel Target for Anti-diabetic Drugs?
Q53842794Permeability and ammonia selectivity in aquaporin TIP2;1: linking structure to function.
Q30661562Phylogenomic and functional analyses of salmon lice aquaporins uncover the molecular diversity of the superfamily in Arthropoda.
Q47093914Plant and animal aquaporins crosstalk: what can be revealed from distinct perspectives
Q26783211Polyphenols as Modulators of Aquaporin Family in Health and Disease
Q93242362Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism
Q47437862Prognostic implication of aquaporin 1 overexpression in resected lung adenocarcinoma.
Q91724747Protective potential of miR-146a-5p and its underlying molecular mechanism in diverse cancers: a comprehensive meta-analysis and bioinformatics analysis
Q47156105Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization.
Q99565716Quantitative study of unsaturated transport of glycerol through aquaglyceroporin that has high affinity for glycerol
Q35873458Rapid Identification of Novel Inhibitors of the Human Aquaporin-1 Water Channel.
Q39936353Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress.
Q35467146Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia
Q37034791Regulating the Membrane Transport Activity and Death of Cells via Electroosmotic Manipulation
Q89944662Regulation of AQP4 in the Central Nervous System
Q42700389Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration
Q47239441Regulation of Aquaporin Functional Properties Mediated by the Antioxidant Effects of Natural Compounds.
Q39155176Regulation of Transporters and Channels by Membrane-Trafficking Complexes in Epithelial Cells
Q49723467Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins.
Q37690756Role of Aquaporin 1 Signalling in Cancer Development and Progression.
Q55332083Selective localization of IgG from cerebrospinal fluid to brain parenchyma.
Q61950903Sleeve Gastrectomy Reduces Hepatic Steatosis by Improving the Coordinated Regulation of Aquaglyceroporins in Adipose Tissue and Liver in Obese Rats
Q37356107Soybean TIP Gene Family Analysis and Characterization of GmTIP1;5 and GmTIP2;5 Water Transport Activity
Q41999967TRPV4-AQP4 interactions 'turbocharge' astroglial sensitivity to small osmotic gradients.
Q42938187The AQP2 mutation V71M causes nephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog
Q55448142The Emerging Role of microRNAs in Aquaporin Regulation.
Q58579310The Expanding Role of Vesicles Containing Aquaporins
Q39724042The adaptor protein alpha-syntrophin regulates adipocyte lipid droplet growth
Q46364880The aquaporin-4 water channel as a potential drug target in neurological disorders.
Q48111440The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods
Q47320072The potential role of aquaporin 1 on aristolochic acid I induced epithelial mesenchymal transition on HK-2 cells.
Q33762106The potential roles of aquaporin 4 in malignant gliomas
Q43074392The time course changes in expression of aquaporin 4 and aquaporin 1 following global cerebral ischemic edema in rat.
Q90264560The utrophin-beta 2 syntrophin complex regulates adipocyte lipid droplet size independent of adipogenesis
Q52683192The value of multi ultra high-b-value DWI in grading cerebral astrocytomas and its association with aquaporin-4.
Q91996181The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter
Q89896087Tissue Distribution of the Readthrough Isoform of AQP4 Reveals a Dual Role of AQP4ex Limited to CNS
Q38675794Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy
Q42921716Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide
Q36552121Urea transporter proteins as targets for small-molecule diuretics
Q59793511Water transport proteins–aquaporins (AQPs) in cancer biology

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