Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

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Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance is …
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scholarly articleQ13442814

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P819ADS bibcode2009PNAS..106.7437H
P356DOI10.1073/PNAS.0902725106
P3181OpenCitations bibliographic resource ID2603973
P932PMC publication ID2678640
P698PubMed publication ID19383790
P5875ResearchGate publication ID24345955

P2093author name stringLarry J W Miercke
Robert M Stroud
Andrew Sandstrom
Rebecca A Robbins
Joseph D Ho
William E C Harries
Ronald Yeh
Ilya Chorny
P2860cites workNeuromyelitis optica pathogenesis and aquaporin 4Q21245240
Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin ZQ24800246
PROCHECK: a program to check the stereochemical quality of protein structuresQ26778411
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Structure of a glycerol-conducting channel and the basis for its selectivityQ27627520
Structural basis of water-specific transport through the AQP1 water channelQ27637193
Control of the selectivity of the aquaporin water channel family by global orientational tuningQ27638881
Structural Basis of Aquaporin Inhibition by MercuryQ27644190
Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparumQ27650679
High-resolution x-ray structure of human aquaporin 5Q27651968
Coot: model-building tools for molecular graphicsQ27860505
Likelihood-enhanced fast translation functionsQ27860634
Structure validation by Calpha geometry: phi,psi and Cbeta deviationQ27860657
Optimal description of a protein structure in terms of multiple groups undergoing TLS motionQ27860825
The CCP4 suite: programs for protein crystallographyQ27861090
Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protonsQ27919687
Identification of arylsulfonamides as Aquaporin 4 inhibitorsQ27919706
The spectrum of neuromyelitis opticaQ31122077
Aquaporins in the brain: from aqueduct to "multi-duct".Q34005760
The pore dimensions of gramicidin A.Q34020191
What really prevents proton transport through aquaporin? Charge self-energy versus proton wire proposalsQ34183919
Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A.Q34245111
Structural mechanism of plant aquaporin gatingQ34474817
Aquaporins in brain: distribution, physiology, and pathophysiologyQ34580267
Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function.Q35056189
Charge delocalization in proton channels, I: the aquaporin channels and proton blockageQ35220083
From structure to disease: the evolving tale of aquaporin biologyQ35875999
Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamidesQ35885354
Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transportQ35961511
The barrier for proton transport in aquaporins as a challenge for electrostatic models: the role of protein relaxation in mutational calculationsQ36508923
Aquaporin gatingQ36534479
Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissuesQ36674076
A current view of the mammalian aquaglyceroporins.Q36981644
Aquaporin-4 square array assembly: opposing actions of M1 and M23 isoformsQ37089692
The channel architecture of aquaporin 0 at a 2.2-A resolutionQ37557408
Evidence against involvement of aquaporin-4 in cell-cell adhesionQ39949997
Identification of a molecular target for glutamate regulation of astrocyte water permeability.Q40011215
Implications of the aquaporin-4 structure on array formation and cell adhesion.Q40344417
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.Q41717152
On the origin of the electrostatic barrier for proton transport in aquaporinQ43563912
Water permeability of aquaporin-4 is decreased by protein kinase C and dopamineQ44058277
Acetazolamide reversibly inhibits water conduction by aquaporin-4.Q46180369
Identification of aquaporin 4 inhibitors using in vitro and in silico methodsQ46817469
Inhibition of aquaporin 4 by antiepileptic drugsQ46820895
The mechanism of proton exclusion in aquaporin channelsQ47867203
Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation.Q48493427
Molecular basis of proton blockage in aquaporins.Q48611752
Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action.Q50114413
Differential growth patterns in SCID mice of patient-derived chronic myelogenous leukemiasQ77169427
Memoir on the decomposition of water and of the bodies that it holds in solution by means of galvanic electricity. 1805Q80235798
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectcrystal structureQ895901
Aquaporin 4Q3820749
protein homotetramerizationQ14819258
P304page(s)7437-42
P577publication date2009-05-05
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCrystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance
P478volume106

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cites work (P2860)
Q369170901,3-Propanediol binds inside the water-conducting pore of aquaporin 4: Does this efficacious inhibitor have sufficient potency?
Q397229151,3-propanediol binds deep inside the channel to inhibit water permeation through aquaporins
Q33998198A Combined Metadynamics and Umbrella Sampling Method for the Calculation of Ion Permeation Free Energy Profiles
Q26823889A brief history of macromolecular crystallography, illustrated by a family tree and its Nobel fruits
Q49617164A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance.
Q49900832A structural preview of aquaporin 8 via homology modeling of seven vertebrate isoforms.
Q54205465AQP4 and HIVAN.
Q37773790AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance
Q48535581AQP4 plasma membrane trafficking or channel gating is not significantly modulated by phosphorylation at COOH-terminal serine residues.
Q37875027Advances in the production of membrane proteins in Pichia pastoris
Q64067912An aquaporin mediates cell shape change required for cellular immunity in the beet armyworm, Spodoptera exigua
Q38061462An emerging consensus on aquaporin translocation as a regulatory mechanism
Q24613666Aquaporin 4 and neuromyelitis optica
Q39583655Aquaporin 4 as a NH3 Channel
Q36929281Aquaporin 4 molecular mimicry and implications for neuromyelitis optica
Q36117107Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter
Q47108955Aquaporin Protein-Protein Interactions
Q37066291Aquaporin water channels in the nervous system.
Q34115487Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling
Q30493505Aquaporin-4 (AQP4) associations and array dynamics probed by photobleaching and single-molecule analysis of green fluorescent protein-AQP4 chimeras
Q64242776Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
Q38151920Aquaporin-4 antibodies (NMO-IgG) as a serological marker of neuromyelitis optica: a critical review of the literature
Q50299606Aquaporin-4 passively transports water out of cell
Q33892339Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica.
Q37681294Aquaporins in kidney pathophysiology
Q50299588Aquaporins passively transport water into cells
Q50299589Aquaporins passively transport water out of cells
Q59811213Aquaporins: More Than Functional Monomers in a Tetrameric Arrangement
Q33792739Aquaporins: important but elusive drug targets.
Q27675548Arginine residues at internal positions in a protein are always charged
Q96640769Arterial pulsations drive oscillatory flow of CSF but not directional pumping
Q36431376Astrocytic autoantibody of neuromyelitis optica (NMO-IgG) binds to aquaporin-4 extracellular loops, monomers, tetramers and high order arrays
Q34963829Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays
Q44442427Biochemistry. Watch water flow
Q34377212Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO.
Q58797276Blood Brain Barrier Permeability Could Be a Biomarker to Predict Severity of Neuromyelitis Optica Spectrum Disorders: A Retrospective Analysis
Q26798446Can Stabilization and Inhibition of Aquaporins Contribute to Future Development of Biomimetic Membranes?
Q39441418Chansporter complexes in cell signaling
Q46437798Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains
Q48507949Computing osmotic permeabilities of aquaporins AQP4, AQP5, and GlpF from near-equilibrium simulations.
Q64103306Constructing Supported Cell Membranes with Controllable Orientation
Q37712394Deletional tolerance prevents AQP4-directed autoimmunity in mice
Q26766328Detecting Aquaporin Function and Regulation
Q47870931Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED Nanoscopy
Q26777463Development of the field of structural physiology
Q24628864Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires
Q85121783Electron crystallography and aquaporins
Q27967670Electrostatics of aquaporin and aquaglyceroporin channels correlates with their transport selectivity
Q92403742Essay on Biomembrane Structure
Q64076244Evidence of Aquaporin 4 Regulation by Thyroid Hormone During Mouse Brain Development and in Cultured Human Glioblastoma Multiforme Cells
Q36912740Exploring transmembrane diffusion pathways with molecular dynamics
Q28833921Fragment Screening of Human Aquaporin 1
Q99712174Functional Analysis of Aquaporin Water Permeability Using an Escherichia coli-Based Cell-Free Protein Synthesis System
Q38090892Further advances in the production of membrane proteins in Pichia pastoris
Q64244586Host-Cell Type Dependent Features of Recombinant Human Aquaporin-4 Orthogonal Arrays of Particles-New Insights for Structural and Functional Studies
Q41763722Human AQP1 is a constitutively open channel that closes by a membrane-tension-mediated mechanism
Q41984241Human Aquaporin 4 Gating Dynamics under Perpendicularly-Oriented Electric-Field Impulses: A Molecular Dynamics Study
Q26740107Human Aquaporin-4 and Molecular Modeling: Historical Perspective and View to the Future
Q59137948Human adipose glycerol flux is regulated by a pH gate in AQP10
Q44270711Human aquaporin 4 gating dynamics under and after nanosecond-scale static and alternating electric-field impulses: a molecular dynamics study of field effects and relaxation
Q50105026Identification and Functional Analysis of the First Aquaporin from Striped Stem Borer, Chilo suppressalis.
Q41818298Identification of a point mutation impairing the binding between aquaporin-4 and neuromyelitis optica autoantibodies
Q34685499Identification of two major conformational aquaporin-4 epitopes for neuromyelitis optica autoantibody binding
Q92711848Identification, Expression Patterns and RNA Interference of Aquaporins in Dendroctonus armandi (Coleoptera: Scolytinae) Larvae During Overwintering
Q33769028Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica
Q64103262Inhibitors of Mammalian Aquaporin Water Channels
Q30659358Insect glycerol transporters evolved by functional co-option and gene replacement
Q47216965Iridoids and Other Monoterpenes in the Alzheimer's Brain: Recent Development and Future Prospects
Q36798187Lessons from high-throughput protein crystallization screening: 10 years of practical experience.
Q35647380Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimeras
Q36650364Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles
Q37977551Live-cell imaging of aquaporin-4 supramolecular assembly and diffusion
Q24619462MIPModDB: a central resource for the superfamily of major intrinsic proteins
Q34825240Mechanisms of astrocyte-mediated cerebral edema
Q92928302Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica
Q42005968Molecular Dynamics Simulation of the Effect of Angle Variation on Water Permeability through Hourglass-Shaped Nanopores
Q90903674Molecular Mechanism of T-2 Toxin-Induced Cerebral Edema by Aquaporin-4 Blocking and Permeation
Q38070349Molecular dynamics of water in the neighborhood of aquaporins.
Q41825088Molecular dynamics simulation and bioinformatics study on yeast aquaporin Aqy1 from Pichia pastoris
Q42577895Molecular dynamics simulations on the effect of size and shape on the interactions between negative Au18(SR)14, Au102(SR)44 and Au144(SR)60 nanoparticles in physiological saline.
Q28731718Molecular dynamics study of the archaeal aquaporin AqpM
Q37595928Molecular identification of first putative aquaporins in snails
Q36923605Movement of NH₃ through the human urea transporter B: a new gas channel
Q35583116Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG.
Q48031543Mutation of a single amino acid converts the human water channel aquaporin 5 into an anion channel
Q38619559Myopathy associated with neuromyelitis optica spectrum disorders
Q38018498Na(+),K (+)-ATPase as a docking station: protein-protein complexes of the Na(+),K (+)-ATPase
Q37594405Nanoparticle-Based Delivery of Anaplasma marginale Membrane Proteins; VirB9-1 and VirB10 Produced in the Pichia pastoris Expression System
Q51175274Near-microsecond human aquaporin 4 gating dynamics in static and alternating external electric fields: Non-equilibrium molecular dynamics.
Q36650382Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly
Q36911907Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies
Q35013123Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion.
Q35002005New tools in membrane protein determination
Q30610471Optic neuritis in neuromyelitis optica
Q26999901Optimal permeability of aquaporins: a question of shape?
Q24607996Optimizing water permeability through the hourglass shape of aquaporins
Q35214601Overexpression of membrane proteins from higher eukaryotes in yeasts
Q39160903Phosphorylation of rat aquaporin-4 at Ser(111) is not required for channel gating.
Q64245619Phosphorylation-Dependent Regulation of Mammalian Aquaporins
Q26866009Physiological roles of aquaporin-4 in brain
Q50117395Plant and Mammal Aquaporins: Same but Different.
Q47093914Plant and animal aquaporins crosstalk: what can be revealed from distinct perspectives
Q28069703Pollen Aquaporins: The Solute Factor
Q35870383Post-Golgi supramolecular assembly of aquaporin-4 in orthogonal arrays
Q26849743Post-expression strategies for structural investigations of membrane proteins
Q33707547Preparative scale production of functional mouse aquaporin 4 using different cell-free expression modes
Q55437236Protective effects of nicorandil against cerebral injury in a swine cardiac arrest model.
Q38205379Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production.
Q47156105Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization.
Q35873458Rapid Identification of Novel Inhibitors of the Human Aquaporin-1 Water Channel.
Q39365229Rapid expression screening of eukaryotic membrane proteins in Pichia pastoris
Q41520019Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease
Q38335788Regulation and Function of AQP4 in the Central Nervous System
Q89944662Regulation of AQP4 in the Central Nervous System
Q37443850Reversible, temperature-dependent supramolecular assembly of aquaporin-4 orthogonal arrays in live cell membranes
Q47887199SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.
Q34154265Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.
Q37776038Strategies for the cloning and expression of membrane proteins
Q55613491Structural Basis for Mutations of Human Aquaporins Associated to Genetic Diseases.
Q36727389Structural Determinants of Oligomerization of the Aquaporin-4 Channel.
Q37736656Structural insights into eukaryotic aquaporin regulation.
Q39975596Structural insights into the Aedes aegypti aquaporins and aquaglyceroporins - an in silico study
Q33849950Structural physiology based on electron crystallography
Q27678613Subangstrom Resolution X-Ray Structure Details Aquaporin-Water Interactions
Q36451210Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes.
Q24609995TMPad: an integrated structural database for helix-packing folds in transmembrane proteins
Q38235835Tetra detector analysis of membrane proteins
Q26767391The Immunology of Neuromyelitis Optica-Current Knowledge, Clinical Implications, Controversies and Future Perspectives
Q36323490The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding
Q26768170The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells-a Potential Target for Pharmacological Intervention in Cardiovascular Diseases
Q37094379The Water Permeability and Pore Entrance Structure of Aquaporin-4 Depend on Lipid Bilayer Thickness
Q46364880The aquaporin-4 water channel as a potential drug target in neurological disorders.
Q30423273The collection of high-resolution electron diffraction data
Q34658040The gating mechanism of the human aquaporin 5 revealed by molecular dynamics simulations
Q34090835The recombinant expression systems for structure determination of eukaryotic membrane proteins
Q91996181The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter
Q59808064Transprotein-Electropore Characterization: A Molecular Dynamics Investigation on Human AQP4
Q33596003Tuning microbial hosts for membrane protein production
Q57097193Uniform isotope labeling of a eukaryotic seven-transmembrane helical protein in yeast enables high-resolution solid-state NMR studies in the lipid environment
Q36489507Unlocking the eukaryotic membrane protein structural proteome
Q33771242Voltage-regulated water flux through aquaporin channels in silico
Q92335619Water channel pore size determines exclusion properties but not solute selectivity
Q36379107Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity
Q42933382Water transport in human aquaporin-4: molecular dynamics (MD) simulations
Q27683366X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking
Q46602374Yeast-expressed human membrane protein aquaporin-1 yields excellent resolution of solid-state MAS NMR spectra.

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