Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease

article

Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/CELLS8020090
P932PMC publication ID6406241
P698PubMed publication ID30691235

P2093author name stringSimone Mader
Lior Brimberg
P2860cites workAquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema.Q46651668
Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways.Q47733635
Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis.Q47789942
Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED NanoscopyQ47870931
Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis opticaQ48172406
Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosisQ48219268
Enhanced expression of aquaporin 4 in human brain with infarctionQ48325351
Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytesQ48382828
Aquaporin 4 changes in rat brain with severe hydrocephalusQ48479571
Aquaporin-4 serostatus does not predict response to immunotherapy in neuromyelitis optica spectrum disordersQ48597814
Onset of aquaporin-4 expression in the developing mouse brain.Q48722671
Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.Q48823528
Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson's Disease.Q48875614
Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica.Q50080563
Complement activation in patients with neuromyelitis optica.Q51063863
Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden.Q51767352
β-Amyloid accumulation in the human brain after one night of sleep deprivation.Q52597873
Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis.Q54558331
Aquaporin-4 Autoantibodies From Neuromyelitis Optica Spectrum Disorder Patients Induce Complement-Independent Immunopathologies in Mice.Q55498468
Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastomaQ57059935
The glymphatic pathway in neurological disordersQ57788282
Clinical and immunological follow-up of B-cell depleting therapy in CNS demyelinating diseasesQ59273782
Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseasesQ59273794
Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat.Q64986695
Comparison of in vitro antibody-targeted cytotoxicity using mouse, rat and human effectorsQ74169935
Altered blood-brain barrier integrity in adult aquaporin-4 knockout miceQ80724299
Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitisQ82449168
Syntrophin-dependent expression and localization of Aquaporin-4 water channel proteinQ24555081
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balanceQ24563954
Aquaporin 4 and neuromyelitis opticaQ24613666
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.Q24631193
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channelQ24646531
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductanceQ24648744
Aquaporins and Brain TumorsQ26745578
International consensus diagnostic criteria for neuromyelitis optica spectrum disordersQ26824579
Physiological roles of aquaporin-4 in brainQ26866009
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficitsQ27301321
The Indispensable Roles of Microglia and Astrocytes during Brain DevelopmentQ28067530
The Glymphatic System: A Beginner's GuideQ28084591
The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brainQ28117909
Treatment of neuromyelitis optica: state-of-the-art and emerging therapiesQ28245749
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeuticsQ29614972
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosisQ29615952
Oligodendrocytes: biology and pathologyQ30051584
Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsyQ30974448
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre.Q31110030
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritisQ33381309
Posterior reversible encephalopathy syndrome in neuromyelitis optica spectrum disordersQ33411707
Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: a combined MRI-histological studyQ33437971
Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis opticaQ33576962
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.Q33656297
Hydrocephalus in neuromyelitis opticaQ33672598
Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivationQ33714909
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis opticaQ33727402
Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brainQ33739948
Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophreniaQ33804875
Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica.Q33892339
Aquaporins in the brain: from aqueduct to "multi-duct".Q34005760
Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis opticaQ34338762
AQP4 autoantibody assay performance in clinical laboratory serviceQ34368662
Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO.Q34377212
Three distinct roles of aquaporin-4 in brain function revealed by knockout miceQ34505493
Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching methodQ34542751
The role of aquaporin-4 in synaptic plasticity, memory and diseaseQ34552951
Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arraysQ34963829
Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS).Q35052199
Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis opticaQ35234452
Aquaporin-4 expression is increased in oedematous human brain tumours.Q35465645
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeetQ35471502
Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis opticaQ35626822
Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disordersQ35753620
Aquaporin-4 antibody isoform binding specificities do not explain clinical variations in NMOQ35764733
Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays.Q35776490
Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.Q35857869
Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cordQ36328228
Long non-coding RNAs in corticogenesis: deciphering the non-coding code of the brainQ36394663
Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes.Q36451210
Coverage of blood vessels by astrocytic endfeet is reduced in major depressive disorderQ36625760
Sporadic obstructive hydrocephalus in Aqp4 null mice.Q36638956
Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissuesQ36674076
Aquaporin water channels in the nervous system.Q37066291
Aquaporin-4 square array assembly: opposing actions of M1 and M23 isoformsQ37089692
Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis opticaQ37235868
Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brainQ37277317
The AQP structure and functional implicationsQ37354952
AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology.Q37433008
Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cellsQ37467723
Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica.Q37472990
Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitroQ37520888
Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellumQ37557777
Aquaporins and neurodegenerative diseases.Q37814121
Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis opticaQ38429895
Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment coursesQ38625492
Understanding the functions and relationships of the glymphatic system and meningeal lymphaticsQ38634466
Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated miceQ38666438
Hydrocephalus: the role of cerebral aquaporin-4 channels and computational modeling considerations of cerebrospinal fluidQ38825774
T cell-activation in neuromyelitis optica lesions plays a role in their formation.Q39039987
Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging BrainsQ39148351
Pathogenic T cell responses against aquaporin 4.Q39563633
Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigenQ39745877
Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo.Q39770767
Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodiesQ39881740
Implications of the aquaporin-4 structure on array formation and cell adhesion.Q40344417
Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4.Q41104307
The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosisQ41683003
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.Q41717152
Aquaporin-4 expression in the cerebrospinal fluid in congenital human hydrocephalus.Q41952763
Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation.Q42164920
Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4.Q42487285
Interferon Beta treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titersQ42942128
Potential utility of aquaporin modulators for therapy of brain disordersQ43225155
Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4.Q44241235
Increased seizure threshold in mice lacking aquaporin-4 water channelsQ44839011
Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cellsQ44901021
Complement-dependent and -independent aquaporin 4-antibody-mediated cytotoxicity in human astrocytes: Pathogenetic implications in neuromyelitis opticaQ44945605
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice.Q45060496
The "glymphatic" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation?Q45985362
Chronic ceftriaxone treatment rescues hippocampal memory deficit in AQP4 knockout mice via activation of GLT-1.Q46214907
Glia protein aquaporin-4 regulates aversive motivation of spatial memory in Morris water maze.Q46219090
An open label study of the effects of rituximab in neuromyelitis opticaQ46482210
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
aquaporinQ623090
glymphatic systemQ15474254
aquaporin-4Q26987778
P304page(s)90
P577publication date2019-01-27
P1433published inCellsQ27724621
P1476titleAquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
P478volume8

Reverse relations

cites work (P2860)
Q89736188Altered Waste Disposal System in Aging and Alzheimer's Disease: Focus on Astrocytic Aquaporin-4
Q104570381Astroglial cells as neuroendocrine targets in forebrain development: implications for sex differences in psychiatric disease
Q92544496Cerebrospinal Fluid Analysis in Multiple Sclerosis Diagnosis: An Update
Q99612681Overview of Current Drug Delivery Methods Across the Blood-Brain Barrier for the Treatment of Primary Brain Tumors
Q90070819The Medical Management of Cerebral Edema: Past, Present, and Future Therapies

Search more.