Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2

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Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2 is …
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scholarly articleQ13442814

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P356DOI10.1053/J.GASTRO.2009.07.078
P932PMC publication ID2855721
P698PubMed publication ID19818778
P5875ResearchGate publication ID26884543

P50authorGerhard RoglerQ64750687
Martin HausmannQ73799368
P2093author name stringAchim Weber
Michael Scharl
Kim E Barrett
Declan F McCole
Gisela Paul
Michael J Docherty
Barbara C Jung
P2860cites workInflammatory Bowel DiseaseQ22248115
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTPQ24296501
Identification of a nuclear Stat1 protein tyrosine phosphataseQ24302061
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylationQ24308062
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTPQ24321559
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphataseQ24522441
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsQ24550675
Manner of interaction of heterogeneous claudin species within and between tight junction strandsQ24683327
How cells respond to interferonsQ27861006
Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alphaQ28212968
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cellsQ28214827
Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphataseQ28217313
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory diseaseQ28511860
Stat3 as an oncogeneQ29614606
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityQ29614872
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's diseaseQ33249005
The T-cell protein tyrosine phosphataseQ34038105
Combinatorial control of the specificity of protein tyrosine phosphatasesQ34180660
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudinsQ34234275
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayersQ34567309
Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel diseaseQ35594920
Altered permeability in inflammatory bowel disease: pathophysiology and clinical implicationsQ36838883
The role of signal transducers and activators of transcription in colon cancerQ36992565
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's diseaseQ37284963
DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sitesQ38307243
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.Q40024709
Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases.Q40453982
Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretionQ40704960
Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier functionQ40811303
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.Q40969960
Claudins regulate the intestinal barrier in response to immune mediatorsQ42488651
Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP.Q42826816
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.Q45200144
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohortQ46143456
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.Q46592696
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitisQ46625501
Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular poresQ47608346
Decreased expression of apical Na+ channels and basolateral Na+, K+-ATPase in ulcerative colitis.Q47631066
Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitisQ56972218
The role of interferon gamma in the pathogenesis of Crohn's diseaseQ68084879
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectCrohn's diseaseQ1472
P304page(s)2030-2040.e5
P577publication date2009-10-08
P1433published inGastroenterologyQ4039279
P1476titleProtection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2
P478volume137

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