scholarly article | Q13442814 |
P50 | author | Gerhard Rogler | Q64750687 |
Martin Hausmann | Q73799368 | ||
P2093 | author name string | Achim Weber | |
Michael Scharl | |||
Kim E Barrett | |||
Declan F McCole | |||
Gisela Paul | |||
Michael J Docherty | |||
Barbara C Jung | |||
P2860 | cites work | Inflammatory Bowel Disease | Q22248115 |
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP | Q24296501 | ||
Identification of a nuclear Stat1 protein tyrosine phosphatase | Q24302061 | ||
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation | Q24308062 | ||
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP | Q24321559 | ||
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase | Q24522441 | ||
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | Q24550675 | ||
Manner of interaction of heterogeneous claudin species within and between tight junction strands | Q24683327 | ||
How cells respond to interferons | Q27861006 | ||
Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha | Q28212968 | ||
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells | Q28214827 | ||
Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase | Q28217313 | ||
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease | Q28511860 | ||
Stat3 as an oncogene | Q29614606 | ||
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility | Q29614872 | ||
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease | Q33249005 | ||
The T-cell protein tyrosine phosphatase | Q34038105 | ||
Combinatorial control of the specificity of protein tyrosine phosphatases | Q34180660 | ||
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins | Q34234275 | ||
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers | Q34567309 | ||
Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease | Q35594920 | ||
Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications | Q36838883 | ||
The role of signal transducers and activators of transcription in colon cancer | Q36992565 | ||
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease | Q37284963 | ||
DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites | Q38307243 | ||
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. | Q40024709 | ||
Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. | Q40453982 | ||
Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion | Q40704960 | ||
Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function | Q40811303 | ||
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. | Q40969960 | ||
Claudins regulate the intestinal barrier in response to immune mediators | Q42488651 | ||
Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP. | Q42826816 | ||
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. | Q45200144 | ||
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort | Q46143456 | ||
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. | Q46592696 | ||
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis | Q46625501 | ||
Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores | Q47608346 | ||
Decreased expression of apical Na+ channels and basolateral Na+, K+-ATPase in ulcerative colitis. | Q47631066 | ||
Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis | Q56972218 | ||
The role of interferon gamma in the pathogenesis of Crohn's disease | Q68084879 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Crohn's disease | Q1472 |
P304 | page(s) | 2030-2040.e5 | |
P577 | publication date | 2009-10-08 | |
P1433 | published in | Gastroenterology | Q4039279 |
P1476 | title | Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2 | |
P478 | volume | 137 |
Q83233518 | A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes |
Q34989162 | Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis |
Q39389508 | An Overview of Inflammatory Bowel Disease: General Consideration and Genetic Screening Approach in Diagnosis of Early Onset Subsets |
Q35668323 | Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin |
Q43616259 | Association between the PTPN2 gene and Crohn's disease: dissection of potential causal variants |
Q35017536 | Associations between PTPN2 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis |
Q27000548 | Claudins in intestines: Distribution and functional significance in health and diseases |
Q38026391 | Commensal-innate immune miscommunication in IBD pathogenesis |
Q45159554 | Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy. |
Q92573806 | Deletion of Protein Tyrosine Phosphatase Nonreceptor Type 2 in Intestinal Epithelial Cells Results in Upregulation of the Related Phosphatase Protein Tyrosine Phosphatase Nonreceptor Type 23 |
Q37774322 | Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease. |
Q26770562 | Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease |
Q29616350 | Genetics and pathogenesis of inflammatory bowel disease |
Q35921093 | Genetics of serum concentration of IL-6 and TNFα in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis |
Q43184075 | IBD candidate genes and intestinal barrier regulation |
Q37781315 | Importance of disrupted intestinal barrier in inflammatory bowel diseases |
Q64107990 | Increased Risk of Diabetes in Inflammatory Bowel Disease Patients: A Nationwide Population-based Study in Korea |
Q38902578 | Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair |
Q35694060 | Interferon-γ alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells: functional consequences for ion transport |
Q37205898 | Intestinal epithelium and autophagy: partners in gut homeostasis |
Q34212116 | Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion |
Q41218016 | Microbial sensing by the intestinal epithelium in the pathogenesis of inflammatory bowel disease |
Q37197950 | Novel mechanism of cytokine-induced disruption of epithelial barriers: Janus kinase and protein kinase D-dependent downregulation of junction protein expression |
Q91671317 | PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus |
Q35506437 | PTPN2 controls differentiation of CD4⁺ T cells and limits intestinal inflammation and intestinal dysbiosis |
Q34211942 | PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background |
Q34044630 | PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. |
Q37728541 | Phosphatase regulation of intercellular junctions |
Q42905042 | Protein Tyrosine Phosphatase non-Receptor Type 2 regulates IFN-γ-induced cytokine signaling in THP-1 monocytes |
Q26774570 | Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease |
Q42479250 | Protein tyrosine phosphatase nonreceptor type 2: an important regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts. |
Q37088189 | Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22 |
Q39448315 | Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease |
Q39336319 | Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2. |
Q91756829 | Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2 |
Q27015639 | Review article: vitamin D and inflammatory bowel disease--established concepts and future directions |
Q35085007 | Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation |
Q52916530 | Significance of serum Il-9 levels in inflammatory bowel disease. |
Q37289295 | Spermidine stimulates T cell protein-tyrosine phosphatase-mediated protection of intestinal epithelial barrier function. |
Q46115480 | T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells. |
Q93197905 | The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation |
Q46235419 | The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action |
Q89387343 | The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients |
Q38202872 | The role of autophagy in Crohn's disease |
Q38232289 | The role of vitamin D in gastrointestinal inflammation |
Q58096686 | The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration |
Q38732337 | VSL#3 Probiotic Stimulates T-cell Protein Tyrosine Phosphatase-mediated Recovery of IFN-γ-induced Intestinal Epithelial Barrier Defects |
Q38155096 | Vitamin D and Crohn's disease in the adult patient: a review. |
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