Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.

scientific article

Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1242/DEV.100271
P932PMC publication ID4074211
P698PubMed publication ID24353058
P5875ResearchGate publication ID259387311

P50authorRaphael KopanQ41898306
P2093author name stringZhenyi Liu
Scott C Boyle
P2860cites workGeneralized lacZ expression with the ROSA26 Cre reporter strainQ27860837
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiencyQ28203380
Skeletal and CNS defects in Presenilin-1-deficient miceQ28238795
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle developmentQ28267098
The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney developmentQ28508689
Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouseQ28512852
The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1Q28585172
Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal developmentQ28586643
A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidneyQ28587526
Universal PCR genotyping assay that achieves single copy sensitivity with any primer pairQ73717596
Mouse models of diabetic nephropathyQ83665875
Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruliQ28588857
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney developmentQ28592487
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathwayQ28592687
Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidneyQ28594297
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cellsQ28594415
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutationQ28646236
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
A robust and high-throughput Cre reporting and characterization system for the whole mouse brainQ29616609
Identification of molecular compartments and genetic circuitry in the developing mammalian kidneyQ30419294
Development of the renal arteriolesQ30423671
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.Q30497988
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisQ33556248
The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.Q33615861
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney developmentQ33904019
Defining the molecular character of the developing and adult kidney podocyteQ34023821
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fateQ34195292
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cellsQ35208718
Stromal progenitors are important for patterning epithelial and mesenchymal cell types in the embryonic kidney.Q35588775
Notch Signaling in the VasculatureQ36861805
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CREQ36973782
Development of the renal glomerulus: good neighbors and good fencesQ37053984
Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.Q37235452
Advances in early kidney specification, development and patterningQ37424512
Podocytes and glomerular function with agingQ37484905
Notch signaling in cardiac development and disease.Q37785202
Notch Signaling in the Regulation of Stem Cell Self-Renewal and DifferentiationQ37785203
Notch signaling in solid tumors.Q37785204
Notch-independent functions of CSL.Q37954780
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signalingQ40927150
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.Q43213014
Proximal tubule morphology after single nephron obstruction in the rat kidney.Q50906374
Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival.Q52027611
Expression of green fluorescent protein in the ureteric bud of transgenic mice: a new tool for the analysis of ureteric bud morphogenesis.Q52177242
The glomerular mesangium: studies of its developmental origin and markers in vivo and in vitroQ52208618
Generation of new Notch2 mutant alleles.Q54623726
Glomerular and proximal tubular morphology after single nephron obstructionQ69409509
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmesangial cellQ3331086
P1104number of pages9
P304page(s)346-354
P577publication date2013-12-18
P1433published inDevelopmentQ3025404
P1476titleNotch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development
P478volume141

Reverse relations

cites work (P2860)
Q28069920Development of the Mammalian Kidney
Q39218625Developmental origins and functions of stromal cells in the normal and diseased mammalian kidney
Q35667541Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis.
Q47992101Forced expression of vascular endothelial growth factor-A in podocytes decreases mesangial cell numbers and attenuates endothelial cell differentiation in the mouse glomerulus
Q38611222Glomerular Mesangial Cell Recruitment and Function Requires the Co-Receptor Neuropilin-1.
Q48110558Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling
Q39242434Growth Factor Regulation in the Nephrogenic Zone of the Developing Kidney
Q34469453Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis
Q54980840Inactivation of Map3k7 in Foxd1-expressing cells results in loss of mesangial PDGFRβ and juvenile kidney scarring.
Q90685529Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds
Q35770285Kidney Regeneration: Lessons from Development
Q88912690MicroRNA‑92a‑3p inhibits the cell proliferation, migration and invasion of Wilms tumor by targeting NOTCH1
Q64069688Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathway
Q39242453Origin and Function of the Renal Stroma in Health and Disease
Q47228308Paragangliomas arise through an autonomous vasculo-angio-neurogenic program inhibited by imatinib
Q39761428Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development
Q38240360Patterning the renal vascular bed.
Q35928099Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.
Q34496903Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.
Q38768831Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development
Q36941787Sesamin Ameliorates High-Fat Diet-Induced Dyslipidemia and Kidney Injury by Reducing Oxidative Stress
Q56946020The multisystemic functions of FOXD1 in development and disease
Q48146490Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway