The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.

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The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YDBIO.2009.11.017
P932PMC publication ID2812695
P698PubMed publication ID19914235
P5875ResearchGate publication ID38090210

P50authorRaphael KopanQ41898306
Colin T StomberskiQ61161529
Kameswaran SurendranQ83763706
P2093author name stringScott Boyle
Mijin Kim
Brent McCright
Hila Barak
P2860cites workNOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathwayQ24293498
Segmental expression of Notch and Hairy genes in nephrogenesisQ24299797
Mutations in NOTCH1 cause aortic valve diseaseQ24307999
SHARP is a novel component of the Notch/RBP-Jkappa signalling pathwayQ24534941
RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription ComplexQ27650201
The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoterQ28142369
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiencyQ28203380
Alagille syndrome and the Jagged1 geneQ28211430
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney developmentQ28506499
Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesisQ28509264
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidneyQ28512634
Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidneyQ28586205
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney developmentQ28592487
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathwayQ28592687
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cellsQ28594415
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Notch signaling is essential for vascular morphogenesis in miceQ29620377
Conditional JAG1 mutation shows the developing heart is more sensitive than developing liver to JAG1 dosageQ33905006
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiationQ34077697
Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cellsQ34760390
Intrinsic epithelial cells repair the kidney after injuryQ34765013
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signalingQ35616437
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.Q35749862
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturationQ36229695
The cellular basis of kidney developmentQ36527712
Molecular insights into segmentation along the proximal-distal axis of the nephron.Q36643537
Regulation of lymphocyte development by Notch signalingQ36794296
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CREQ36973782
Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.Q37235452
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor populationQ37356678
Mutational and energetic studies of Notch 1 transcription complexesQ40031628
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.Q41826001
Intrinsic fluctuations, robustness, and tunability in signaling cyclesQ42773692
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.Q43213014
Central nervous system myelination in mice with deficient expression of Notch1 receptorQ44498405
Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.Q48189137
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells.Q50878030
Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice.Q51951782
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathwayQ52603545
Universal PCR genotyping assay that achieves single copy sensitivity with any primer pairQ73717596
Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesisQ73833078
P433issue2
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)386-395
P577publication date2009-11-13
P1433published inDevelopmental BiologyQ3025402
P1476titleThe contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage
P478volume337

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cites work (P2860)
Q64077358A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
Q38165796Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy
Q33844686Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling
Q35108850Chromatin-based mechanisms of renal epithelial differentiation
Q38715780Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression
Q38247213From ureteric bud to the first glomeruli: genes, mediators, kidney alterations.
Q30525293Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis.
Q90424222Kidney organoids: accurate models or fortunate accidents
Q37785192Mechanistic insights into Notch receptor signaling from structural and biochemical studies
Q27015885Membrane trafficking in podocyte health and disease
Q34207078Morphogenesis and molecular mechanisms involved in human kidney development.
Q37785199Notch Targets and Their Regulation
Q36914833Notch in the kidney: development and disease
Q47428777Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation
Q35208718Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells
Q44592753Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways
Q37785202Notch signaling in cardiac development and disease.
Q37874571Notch signaling in cardiac valve development and disease.
Q33817814Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.
Q37425842Notch signaling promotes nephrogenesis by downregulating Six2.
Q26822965Organ In Vitro Culture: What Have We Learned about Early Kidney Development?
Q28481309Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule
Q33904019Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
Q27334560Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1
Q33834308Reduced Notch signaling leads to renal cysts and papillary microadenomas
Q54839579Renal anomalies in Alagille syndrome: a disease-defining feature.
Q35178905Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity
Q61445371Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site
Q27342255Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster
Q33926410The GUDMAP database--an online resource for genitourinary research
Q28508689The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development
Q34869243Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes
Q37785198Two Opposing Roles of RBP-J in Notch Signaling
Q37795569WT1 and kidney progenitor cells
Q91105928β-catenin regulates the formation of multiple nephron segments in the mouse kidney

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