The NOD mouse model of type 1 diabetes: as good as it gets?

scientific article

The NOD mouse model of type 1 diabetes: as good as it gets? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/9442
P698PubMed publication ID10371488
P5875ResearchGate publication ID12926573

P2093author name stringLeiter EH
Atkinson MA
P2860cites workThe nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.Q34452348
Kilham rat triggers T-cell-dependent autoimmune diabetes in multiple strains of rat.Q42629147
An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitusQ47785242
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecttype-1 diabetesQ124407
P304page(s)601-604
P577publication date1999-06-01
P1433published inNature MedicineQ1633234
P1476titleThe NOD mouse model of type 1 diabetes: as good as it gets?
P478volume5

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cites work (P2860)
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Q38660322Animal models of human type 1 diabetes for evaluating combination therapies and successful translation to the patient with type 1 diabetes.
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Q36766166Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth
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Q38034269At the crossroad of T cells, adipose tissue, and diabetes
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Q38106720Bone marrow stem cell as a potential treatment for diabetes
Q44347477CD8+ regulatory T cells are responsible for GAD-IgG gene-transferred tolerance induction in NOD mice
Q36399304CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice
Q36501954Cannabidiol arrests onset of autoimmune diabetes in NOD mice
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Q33705115Cathepsin L Inhibition Prevents Murine Autoimmune Diabetes via Suppression of CD8+ T Cell Activity
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Q35852428Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice
Q55083872Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models.
Q56902182Costimulation and autoimmune diabetes in BB rats
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Q42200757Coxsackievirus can persist in murine pancreas by deletion of 5' terminal genomic sequences
Q44325323Coxsackievirus immunization delays onset of diabetes in non-obese diabetic mice
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Q47626694Current practices and future outlook on the integration of biomarkers in the drug development process
Q35116303Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same?
Q26799371Current status and patent prospective of animal models in diabetic research
Q35405027Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice
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Q53623250Deregulated stress system in non-obese diabetic lymphocyte.
Q34790078Detecting early-warning signals of type 1 diabetes and its leading biomolecular networks by dynamical network biomarkers
Q35851189Detection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers
Q33508234Detection of molecular paths associated with insulitis and type 1 diabetes in non-obese diabetic mouse
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Q35622028Development of new strategies to prevent type 1 diabetes: the role of animal models.
Q35101430Development of type 1 diabetes mellitus in nonobese diabetic mice follows changes in thymocyte and peripheral T lymphocyte transcriptional activity
Q43115993Diabetes-associated dry eye syndrome in a new humanized transgenic model of type 1 diabetes
Q47234300Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice
Q38340376Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1.
Q36225473Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model.
Q36019487Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus.
Q34660693Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats
Q35946087Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
Q50882981ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB.
Q38382091Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes
Q38189119Effector and regulatory T cell subsets in diabetes-associated inflammation. Is there a connection with ST2/IL-33 axis? Perspective.
Q44655252Effects of streptozotocin on autoimmune diabetes in NOD mice
Q37163580Elimination of T cell reactivity to pancreatic β cells and partial preservation of β cell activity by peptide blockade of LFA-1:ICAM-1 interaction in the NOD mouse model
Q64230036Endogenous Pancreatic β Cell Regeneration: A Potential Strategy for the Recovery of β Cell Deficiency in Diabetes
Q47557792Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.
Q96951726Engineering immunomodulatory biomaterials for type 1 diabetes
Q37668475Enteroviruses, type 1 diabetes and hygiene: a complex relationship
Q44814113European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes
Q34208736Evaluating preclinical efficacy
Q91691061Extracellular matrix and the maintenance and loss of peripheral immune tolerance in autoimmune insulitis
Q35024527Extreme genetic risk for type 1A diabetes
Q39740128Fatal attraction: chemokines and type 1 diabetes
Q34323684Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes
Q35122170Gene- and cell-based therapeutics for type I diabetes mellitus
Q35796924Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts
Q36570968Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance
Q44524587Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes
Q35539009Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice
Q28215982Genetics of type 1 diabetes mellitus
Q30883833Genome-wide end-sequenced BAC resources for the NOD/MrkTac() and NOD/ShiLtJ() mouse genomes
Q36235501Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse
Q34072322Glucose homeostasis in pre-diabetic NOD and lymphocyte-deficient NOD/SCID mice during gestation
Q33894591Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetes
Q34648219Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency
Q34346057Growth of rotaviruses in primary pancreatic cells
Q44893510Guidelines for Intervention Trials in Subjects With Newly Diagnosed Type 1 Diabetes
Q35578236Harnessing the Immunomodulatory Properties of Sertoli Cells to Enable Xenotransplantation in Type I Diabetes
Q37484889Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis.
Q37248995Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.
Q33992348Hormonal regulation of physiological cell turnover and apoptosis
Q24656069Human T regulatory cell therapy: take a billion or so and call me in the morning
Q49566444Human amylin induces CD4+Foxp3+ regulatory T cells in the protection from autoimmune diabetes
Q44653755IA-2 is not required for the development of diabetes in NOD mice
Q38117368Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment
Q36229062Immune assessments in developmental and juvenile toxicology: practical considerations for the regulatory safety testing of pharmaceuticals
Q34882557Immunologic and genetic factors in type 1 diabetes
Q34790085Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases
Q38102390Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development
Q36167431Immunomodulatory therapy of human type 1 diabetes: lessons from the mouse
Q33815506Immunotherapy of type 1 diabetes: where are we and where should we be going?
Q52430441Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development.
Q36512327Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab')2 treatment-reversed new-onset diabetes in nonobese diabetic mice
Q34527126Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD mice
Q37682917Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4.
Q27334532Inhibition of Autoimmune Diabetes in NOD Mice by miRNA Therapy
Q36165620Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis
Q44967038Inhibition of the proteasome reduces transfer-induced diabetes in nonobese diabetic mice
Q34520643Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes
Q33814945Insulin-dependent diabetes mellitus and its animal models.
Q34542675Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
Q36249643Involvement of sulfatide in beta cells and type 1 and type 2 diabetes
Q46236719Iodine and tri-iodo-thyronine reduce the incidence of type 1 diabetes mellitus in the autoimmune prone BB rats
Q33869101Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct.
Q34479316Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice
Q51006250Islet/pancreas transplantation: challenges for pediatrics.
Q34638339Isomer-specific LC/MS and LC/MS/MS profiling of the mouse serum N-glycome revealing a number of novel sialylated N-glycans
Q98177245Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation
Q36870085Leptin in autoimmunity: many questions, some answers
Q37110531Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes
Q33628140Limited effect of CpG ODN in preventing type 1 diabetes in NOD mice
Q36591024Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice
Q27008200Low-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunity
Q34974382Lower frequency of CD62L(high) and higher frequency of TNFR2(+) Tregs are associated with inflammatory conditions in type 1 diabetic patients
Q36443938Lymphocytes with aberrant expression of Fas or Fas ligand attenuate immune bone marrow failure in a mouse model
Q34064185Metabolic regulation in progression to autoimmune diabetes
Q47735079Modelling diabetic nephropathy in mice.
Q35968974Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice
Q59829524Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies
Q42043629Molecular analysis of an echovirus 3 strain isolated from an individual concurrently with appearance of islet cell and IA-2 autoantibodies
Q34390741Molecular genetic analysis of diabetes in mice
Q33961022NOD mice are defective in proteasome production and activation of NF-kappaB
Q53634474NOD mice are functionally deficient in the capacity of cross-presentation.
Q35798168Natural killer T cells as targets for immunotherapy of autoimmune diseases
Q30843737Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB)
Q35539035Neuronal elements in the pathogenesis of type 1 diabetes
Q36735358Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells
Q34564255New therapeutic approaches to type 1 diabetes: from prevention to cellular or gene therapies
Q22306219Noncalcemic Actions of Vitamin D Receptor Ligands
Q30434071Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes
Q36370946Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
Q29393228Opinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes
Q36640081Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells
Q59600053Overexpression of extracellular-SOD in islets of nonobese diabetic mice and development of diabetes
Q53531845Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction.
Q86967394PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRβ mAb therapy
Q36945852Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Q34605626Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal
Q81658222Porcine IgE in the context of experimental food allergy: purification and isotype-specific antibodies
Q37376932Potential for vitamin D receptor agonists in the treatment of cardiovascular disease
Q37626855Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes
Q34830048Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
Q35107187Premature CD4+ T cell aging and its contribution to lymphopenia-induced proliferation of memory cells in autoimmune-prone non-obese diabetic mice
Q35976659Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35.
Q37532745Prevention of type 1 diabetes by gene therapy
Q35902878Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vβ13 as a therapeutic target and biomarker
Q83168646Pro-apoptotic DNA vaccination ameliorates new onset of autoimmune diabetes in NOD mice and induces foxp3+ regulatory T cells in vitro
Q37821494Protection against or triggering of Type 1 diabetes? Different roles for viral infections
Q54471977Protection of non-obese diabetic mice from autoimmune diabetes by Escherichia coli heat-labile enterotoxin B subunit.
Q36344113Quantification of chemokines by real-time reverse transcriptase PCR: applications in type 1 diabetes
Q46465603Quantitative analysis of total serum glycome in human and mouse
Q42676935Questioning four preconceived ideas on immunotherapy of clinical type 1 diabetes: lessons from recent CD3 antibody trials
Q34387892RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytes
Q37012718Rapid dissemination of RET-transgene-driven melanoma in the presence of non-obese diabetic alleles: Critical roles of Dectin-1 and Nitric-oxide synthase type 2.
Q44719693Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice
Q48186068Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
Q35914938Regulation of immune responses by CD1d-restricted natural killer T cells
Q40096435Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment.
Q34035323Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice
Q24674948Reversal of Sjogren's-like syndrome in non-obese diabetic mice
Q36369174Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor
Q38242389Rodent animal models: from mild to advanced stages of diabetic nephropathy
Q36124501Role of regulatory invariant CD1d-restricted natural killer T-cells in protection against type 1 diabetes
Q40767304Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis
Q36609044Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice.
Q54445458Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis.
Q35923786Spontaneous rodent models of diabetes and diabetic retinopathy
Q27011453Stem cell therapy for diabetes mellitus
Q34391021Stem cell treatment for type 1 diabetes
Q53235135Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR).
Q92988627Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Strategies for In Vivo Administration: Part-II
Q34734082Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells
Q34629092Suppression of dendritic cell activation by diabetes autoantigens linked to the cholera toxin B subunit.
Q35597162T cell-driven initiation and propagation of autoimmune diabetes
Q35702538T-cell epitopes in type 1 diabetes
Q36943737Targeting CD22 reprograms B-cells and reverses autoimmune diabetes
Q54134699The CXCR4/CXCL12 (SDF-1) signalling pathway protects non-obese diabetic mouse from autoimmune diabetes.
Q47913426The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice.
Q48364565The Journal of Gene Medicine 2001 Young Investigator Award
Q90345025The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis
Q55024614The Spleen as an Optimal Site for Islet Transplantation and a Source of Mesenchymal Stem Cells.
Q90350445The challenge of modulating β-cell autoimmunity in type 1 diabetes
Q37759033The immunotherapeutic potential of dendritic cells in type 1 diabetes
Q27026794The microbiology of human hygiene and its impact on type 1 diabetes
Q36367836The natural killer T lymphocyte: a player in the complex regulation of autoimmune diabetes in non-obese diabetic mice
Q37160327The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes
Q34496850The pancreas in human type 1 diabetes
Q35832523The pathogenesis of diabetes in the NOD mouse
Q38110933The potential role of dendritic cells in the therapy of Type 1 diabetes
Q57623514The problems and promises of research into human immunology and autoimmune disease
Q35103993The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure
Q38213215The role of Toll-like receptors and vitamin D in diabetes mellitus type 1--a review
Q36079915The stages of type 1A diabetes: 2005.
Q27023064The streetlight effect in type 1 diabetes
Q35867877Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells
Q34612686Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.
Q36637650Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model
Q35613139Tolerance induction and endogenous regeneration of pancreatic beta-cells in established autoimmune diabetes
Q34359584Toward testing the hypothesis that group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence.
Q28530266Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation
Q43780207Treatment with sulfatide or its precursor, galactosylceramide, prevents diabetes in NOD mice
Q35837580Type 1 Diabetes Prevention in NOD Mice by Targeting DPPIV/CD26 Is Associated with Changes in CD8⁺T Effector Memory Subset
Q35714822Type 1 diabetes: recent developments
Q27320835Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1.
Q34498188Understanding autoimmune diabetes: insights from mouse models.
Q46964184Unexpected functional consequences of xenogeneic transgene expression in beta-cells of NOD mice
Q34078163Use of nonobese diabetic mice to understand human type 1 diabetes
Q36898677Variations in rodent models of type 1 diabetes: islet morphology
Q34581550Viral infections as potential triggers of type 1 diabetes
Q37429158Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex
Q35042163Vitamin D and autoimmune diabetes
Q35878811What can the HLA transgenic mouse tell us about autoimmune diabetes?
Q51362614Zinc supplementation alleviates hyperglycemia and associated metabolic abnormalities in streptozotocin-induced diabetic rats.
Q92217601β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes
Q38730525β-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice